Studies of pyrazoles. XLVI. Synthesis of pyrazolo pyridones

Cyclizations of acetoacetamidopyrazoles and of appropriate aminopyrazole crotonates to pyrazolopyridines with a hydroxy group in the pyridine ring are effected. In the case of an amino group at position 5 in the pyrazole ring cyclization takes place with acetylacetone. It is shown that the structure of pyrazolopyridone put forward by Bülow is incorrect.     

Relaxationseffekte beim Oberfl?chendruck-Verhalten von Dipalmitoyl-Lecithin

Ohne Zusammenfassung     

Continuous and discontinuous solutions for optimum thrust nozzles of given length

In its first sections, the paper deals with optimum thrust nozzles of given length and exit radius for flows with swirl. The computation is based on a modification of methods familiar for flows without swirl. Rather extensive numerical results show that the swirl does not impair the specific impulse attainable at a given nozzle length. The analysis suggests that the assumption of isentropic continuous flows, on which this approach is based, may sometimes be too restrictive. A survey of plane nozzles shows, on the other hand, that discontinuities need to be admitted only if, besides the length, a rather large radius of the nozzle is prescribed. Discontinuous solutions have been thoroughly investigated by Shmyglevskiy. At least in principle, we use the same line of thought, but considerable simplifications are possible if one starts with the variational formulation of Rao. In its numerical discussion and also in some analytical details, the present paper goes beyond Shmyglevskiy's results. The problem is conveniently discussed in astate plane, which has the local state of the flow (flow direction and speed or Mach number) as independent variables. By taking into account second variations, one can determine the boundary of the region for which continuous solutions give the (local) maximum. This boundary coincides with the locus of points at which the solution in the physical plane would fold back into itself. Another limitation of the original approach emerges if one asks under which conditions the thrust can be increased by admitting along the control surface values of the entropy that are higher than those of the oncoming flow. The conditions for isentropic and nonisentropic jumps are formulated and evaluated next, and a survey of the discontinuities which satisfy conditions for isentropic and also for selected nonisentropic jumps is given. Up to this point, the analysis is concerned only with the state distribution along the control surface. Jumps of the state in the interior require the occurrence of centered compression waves. Sample computations show that, in most cases, flow fields of this character can be generated by the choice of the nozzle shape. In some cases, no nozzle contours exist which generate the optimizing state distribution along the control surface as determined by the present analysis. It would then be necessary to include from the very beginning conditions for the realizability of the flow field.     

Explanation of Variability and Removal of Confounding Factors from Data through Optimal Transport

A methodology based on the theory of optimal transport is developed to attribute variability in data sets to known and unknown factors and to remove such attributable components of the variability from the data. Denoting by x the quantities of interest and by z the explanatory factors, the procedure transforms x into filtered variables y through a z‐dependent map, so that the conditional probability distributions ρ(x|z) are pushed forward into a target distribution μ(y), independent of z. Among all maps and target distributions that achieve this goal, the procedure selects the one that minimally distorts the original data: the barycenter of the ρ(x|z). Connections are found to unsupervised learning and to fundamental problems in statistics such as conditional density estimation and sampling. Particularly simple instances of the methodology are shown to be equivalent to k‐means and principal component analysis. An application is shown to a time series of ground temperature hourly data across the United States.© 2017 Wiley Periodicals, Inc.     

Evolution of bank efficiency in Brazil: A DEA approach

This paper investigates cost, technical and allocative efficiencies for Brazilian banks in the recent period (2000–2007). We use Data Envelopment Analysis (DEA) to compute efficiency scores. Brazilian banks were found to have low levels of economic (cost) efficiency compared to banks in Europe and in the US. For the period with high macroeconomic volatility (2000–2002) the economic inefficiency in Brazilian banks can be attributed mainly to technical inefficiency rather than allocative inefficiency. State-owned banks are significantly more cost efficient than foreign, private domestic and private with foreign participation. There is no evidence of differences in economic efficiency due to type of activity and bank size. These results may provide some useful guidance for financial regulators and bank managers.     

Absorption of short laser pulses on solid targets in the ultrarelativistic regime

We report the first direct measurements of total absorption of short laser pulses on solid targets in the ultrarelativistic regime. The data show an enhanced absorption at intensities above 10(20) W/cm(2), reaching 60% for near-normal incidence and 80%-90% for 45 degrees incidence. Two-dimensional particle-in-cell simulations demonstrate that such high absorption is consistent with both interaction with preplasma and hole boring by the intense laser pulse. A large redshift in the second harmonic indicates a surface recession velocity of 0.035c.     

Hot-electron energy coupling in ultraintense laser-matter interaction

We investigate the hydrodynamic response of plasma gradients during the interaction with ultraintense energetic laser pulses, using kinetic particle simulations. Energetic laser pulses are capable of compressing preformed plasma gradients over short times while accelerating low-density plasma backwards. As light is absorbed on a steepened interface, hot-electron temperature and coupling efficiency drop below the ponderomotive scaling, and we are left with a new absorption mechanism that strongly relies on the electrostatic potential caused by low-density preformed plasma. We describe this process, explain electron spectra, and identify the parameter regime where strong compression occurs. Finally, we discuss the implications for fast ignition and other applications.     

电感耦合等离子体-发射光谱法（ICP-AES）快速测定饮用水中8种微量元素

用电感耦合等离子体-发射光谱法（ICP-AES）同时快速测定饮用水中微量的铜、铅、锌、铁、锰、镉、铬、砷,具有快速、简便、灵敏度高等优点,精密度为1．2％～8．2％（RSD,n=5）．回收率为90％～110％．     

Interaction of giant extracellular Glossoscolex paulistus hemoglobin (HbGp) with zwitterionic surfactant N-hexadecyl-N,N-dimethyl-3-ammonio-1-propanesulfonate (HPS): effects of oligomeric dissociation

The present work focuses on the interaction between the zwitterionic surfactant N-hexadecyl-N,N-dimethyl-3-ammonio-1-propanesulfonate (HPS) and the giant extracellular hemoglobin of Glossoscolex paulistus (HbGp). Electronic optical absorption, fluorescence emission and circular dichroism spectroscopy techniques, together with Gel-filtration chromatography, were used in order to evaluate the oligomeric dissociation as well as the autoxidation of HbGp as a function of the interaction with HPS. A peculiar behavior was observed for the HPS–HbGp interaction: a complex ferric species formation equilibrium was promoted, as a consequence of the autoxidation and oligomeric dissociation processes. At pH 7.0, HPS is more effective up to 1 mM while at pH 9.0 the surfactant effect is more intense above 1 mM. Furthermore, the interaction of HPS with HbGp was clearly less intense than the interaction of this hemoglobin with cationic (CTAC) and anionic (SDS) surfactants. Probably, this lower interaction with HPS is due to two factors: (i) the lower electrostatic attraction between the HPS surfactant and the protein surface ionic sites when compared to the electrostatic interaction between HbGp and cationic and anionic surfactants, and (ii) the low cmc of HPS, which probably reduces the interaction of the surfactant in the monomeric form with the protein. The present work emphasizes the importance of the electrostatic contribution in the interaction between ionic surfactants and HbGp. Furthermore, in the whole HPS concentration range used in this study, no folding and autoxidation decrease induced by this surfactant were observed. This is quite different from the literature data on the interaction between surfactants and tetrameric hemoglobins, that supports the occurrence of this behavior for the intracellular hemoglobins at low surfactant concentration range. Spectroscopic data are discussed and compared with the literature in order to improve the understanding of hemoglobin–surfactant interaction as well as the acid isoelectric point (pI) influence of the giant extracellular hemoglobins on their structure–activity relationship.