Determination of Abacavir, Lamivudine and Zidovudine in Pharmaceutical Tablets, Human Serum and in Drug Dissolution Studies by HPLC

A simple, accurate, precise and fully automated method for the simultaneous determination of abacavir, lamivudine and zidovudine in pharmaceutical tablets, human serum samples and drug dissolution studies has been developed. Separation was performed on a 5 μm Zorbax^® C₁₈ column (150 × 4.6 mm ID) with methanol:water:phosphate buffer at pH 5.65 (80:10:10; v/v/v) isocratic elution in less than 7 min with a flow rate of 0.6 mL min^?1.Good sensitivity for all analytes was observed with UV detection at 275 nm. The method allowed quantitation over the 500–3,000 ng mL^?1 range for abacavir and 500–5,000 ng mL^?1 range for lamivudine and zidovudine. The method has been applied, without any interference from excipients or endogenous substances, for the simultaneous determination of these three compounds in tablets. Human serum and drug dissolution studies.     

Electrically driven self‐healing polymers based on reversible guest–host complexation of β‐cyclodextrin and ferrocene

A multifunctional ferrocene‐modified poly(glycidyl methacrylate) (PGMA‐Fc) and a difunctional β‐cyclodextrin derivative (bis‐CD) has been prepared for the construction of an electrically driven removable and self‐healing polymeric materials based on the complexation reaction between ferrocene and β‐CD groups. The chemical structures of PGMA‐Fc and bis‐CD have been characterized with Fourier transform infrared, ¹H nuclear magnetic resonance, and X‐ray photoelectron spectroscopy. The effects of electrical voltages and medium conductivity on the decrosslinking efficiency of the crosslinked PGMA‐Fc/CD polymer have been examined. The PGMA‐Fc/CD network has shown removable feature and properties for application as a reworkable crosslinked material. Moreover, the crosslinked PGMA‐Fc/CD sample has shown electrically driven self‐healing behavior. The self‐healing performance could be enhanced with wetting the sample to increase the electrical conductivity. As a result, the material could serve as a self‐healing agent for commercial painting products. Preparation and application of a novel and efficient self‐healing polymer have been demonstrated. © 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2013 , 51, 3395–3403     

Synthesis,characterization, and catalytic activity of titanium iminophenoxide complexes in relation to the ring‐opening polymerization of L‐lactide and ε‐caprolactone

This study synthesized a series of titanium iminophenoxide complexes and investigated their suitability as catalysts for the ring‐opening polymerization of L ‐lactide (L ‐LA) and ε‐caprolactone (CL). Complexes with bidentate ligands demonstrate higher catalytic activity than their tridentate counterparts since the third coordination atom needs to contend with L ‐LA and CL. Differences in the geometric framework of bidentate ligands also influence the catalytic activity. Type II ligands (N, N‐trans form of Ti complex) prevent the coordination of monomers to Ti thereby decreasing the initiation rate. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2013     

Scaling of betatron X-ray radiation

Energetic electron beams accelerated in a laser-produced plasma wakefield cavity can generate collimated beams of X-ray radiation. The oscillation of the electrons in the plasma cavity produces synchrotron-like emission, called betatron radiation. On the basis of state of the art experiments, we discuss the potentiality of this source in terms of spectral brigthness and flux. These characteristics are compared to existing and planned X-ray sources in both laser and accelerator communities.     

Synthèse de dérivés indoliques substitués in 7

The synthesis and some aspects of the chemical reactivity of 7-acetyl-, 7-benzoyl- and 7-bromoindoles are described.     

Convergent perturbation studies in screened coulomb potential systems: a high precision numerical algorithm via Laguerre basis set

In this work, a high precision algorithm is developed to determine the discrete spectrum of screened coulomb potential systems. The algorithm is mainly based upon the use of the perturbation of a hydrogen-like operator by a bounded operator. The Laguerre basis set expansion is employed in the procedure to obtain the operator inversion. Although a functional analytic analysis of errors and proof of convergence theorem are still lacking, it appears, numerically, that the method rapidly converges for bounded screened coulomb potential. Extremely accurate numerical results for the bound-state energies, in the case of Yukawa potential, are presented for illustrative purposes.     

Fundamental resonance and bifurcation of large generator end winding when its clamping plates are loose

Introduction Theendwindingunderelectromagneticforcewillvibratewhenthegeneratorisrunning. Becauseofeffectofmanyfactors,suchasmanufacturetechniqueandpracticalrunningcondition, thevibrationmayresultinabrasion,fatigueandfractureoftheendwindinginsulation,even makecoilshortcircuited.Thisisoneofthedifficultiesthatpuzzledpeopleinengineeringfield.Forexample,someelectricpowerstationshavehadaccidentssuchasendwindinginsulation frettedwhichresultedinshortcircuitbecauseclampingplatesareloose;Clipofdown_lea…     

A numerical approach to some basic theorems in singularity theory

In this paper, we give the explicit bounds for the data of objects involved in some basic theorems of singularity theory: the inverse, implicit and rank theorems for Lipschitz mappings, the splitting lemma and the Morse lemma, the density and openness of Morse functions. We expect that the results will make singularities more applicable and will be useful for numerical analysis and some fields of computing.     

Phonon dynamics of hexagonal Y Mn1−xFexO3

Phonon dynamics was investigated on Y Mn_1−xFe_xO₃(0≤x≤0.20) hexagonal manganite polycrystals. Phonon modes were properly assigned using results obtained on Y MnO₃ single crystal, by mixing the ab plane and the c axis optical responses. Upon increasing the Fe content, most of the phonon mode frequencies do not vary drastically. However, some modes involving Y and O atom displacements along the c axis are affected by doping. Indeed, a redshift of their transverse optical frequency was interpreted as an elongation of Y-O distance along the c-axis, resulting in a change in yttrium coordination.