Controlled polymerization of lactides at ambient temperature using [5-Cl-salen]AlOMe

The Schiff-base aluminium complex [5-Cl-salen]AlOMe ( 2 ) is shown to be a room temperature initiator for controlled ring-opening polymerization of D ,L - and L -lactides; the molecular structure of the precursor [5-Cl-salen]AlMe ( 1 ) reveals a distorted trigonal bipyramidal geometry.     

Apolipoprotein E Recognizes Alzheimer's Disease Associated 3-O Sulfation of Heparan Sulfate

Apolipoprotein E (ApoE)’s ϵ4 alle is the most important genetic risk factor for late onset Alzheimer's Disease (AD). Cell-surface heparan sulfate (HS) is a cofactor for ApoE/LRP1 interaction and the prion-like spread of tau pathology between cells. 3-O-sulfo (3-O-S) modification of HS has been linked to AD through its interaction with tau, and enhanced levels of 3-O-sulfated HS and 3-O-sulfotransferases in the AD brain. In this study, we characterized ApoE/HS interactions in wildtype ApoE3, AD-linked ApoE4, and AD-protective ApoE2 and ApoE3-Christchurch. Glycan microarray and SPR assays revealed that all ApoE isoforms recognized 3-O-S. NMR titration localized ApoE/3-O-S binding to the vicinity of the canonical HS binding motif. In cells, the knockout of HS3ST1-a major 3-O sulfotransferase-reduced cell surface binding and uptake of ApoE. 3-O-S is thus recognized by both tau and ApoE, suggesting that the interplay between 3-O-sulfated HS, tau and ApoE isoforms may modulate AD risk.     

ChemInform Abstract: Gas Phase Uranyl Activation: Formation of a Uranium Nitrosyl Complex from Uranyl Azide.

The fragmentation chemistry of UO₂(N₃)Cl₂^‐ (obtained by electrospray ionization of MeOH solutions containing UO₂Cl₂ and NaN₃) in the gas phase is investigated using quadrupole ion trap mass spectrometry.