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91.
Brain tumors are the most widespread malignancies in children around the world. Chemotherapy plays a critical role in the treatment of these tumors. Although the current chemotherapy process has a remarkable outcome for a certain subtype of brain tumor, improving patient survival is still a major challenge. Further intensive treatment with conventional non-specific chemotherapy could cause additional adverse reactions without significant advancement in survival. Recently, patient derived brain tumor, xenograft, and whole genome analysis using deep sequencing technology has made a significant contribution to our understanding of cancer treatment. This realization has changed the focus to new agents, targeting the molecular pathways that are critical to tumor survival or proliferation. Thus, many novel drugs targeting epigenetic regulators or tyrosine kinase have been developed. These selective drugs may have less toxicity in normal cells and are expected to be more effective than non-specific chemotherapeutics. This review will summarize the latest novel targets and corresponding candidate drugs, which are promising chemotherapy for brain tumors according to the biological insights. 相似文献
92.
Xiangli Qian Huiying Sun Tianlu Chen Danzengluobu Youliang Feng Qi Gao Quanbu Gou Yiqing Guo Hongbo Hu Mingming Kang Haijin Li Cheng Liu Maoyuan Liu Wei Liu Bingqiang Qiao Xu Wang Zhen Wang Guangguang Xin Yuhua Yao Qiang Yuan Yi Zhang 《Frontiers of Physics》2022,17(6):64602
The High Altitude Detection of Astronomical Radiation (HADAR) experiment is a refracting terrestrial telescope array based on the atmospheric Cherenkov imaging technique. It focuses the Cherenkov light emitted by extensive air showers through a large aperture water-lens system for observing very-high-energy γ-rays and cosmic rays. With the advantages of a large field-of-view (FOV) and low energy threshold, the HADAR experiment operates in a large-scale sky scanning mode to observe galactic sources. This study presents the prospects of using the HADAR experiment for the sky survey of TeV γ-ray sources from TeVCat and provids a one-year survey of statistical significance. Results from the simulation show that a total of 23 galactic point sources, including five supernova remnant sources and superbubbles, four pulsar wind nebula sources, and 14 unidentified sources, were detected in the HADAR FOV with a significance greater than 5 standard deviations (σ). The statistical significance for the Crab Nebula during one year of operation reached 346.0 σ and the one-year integral sensitivity of HADAR above 1 TeV was ~1.3%–2.4% of the flux from the Crab Nebula. 相似文献
93.
94.
研究用于校准场所中子剂量监测仪表的241Am-Be中子参考辐射场计量特性。采用蒙特卡罗方法模拟了空气自由中子参考辐射(FRNR),GB/T 14055规定的最小尺寸中子参考辐射(SRNR)和实际中子参考辐射(ARNR)中不同检验点处中子周围剂量当量率、散射中子占比和能谱分布特征。研究结果表明,空气对FRNR中的剂量率和能谱分布影响小,近似为理想中子参考辐射;采用5%含硼聚乙烯作屏蔽的最小尺寸SRNR可减少热中子,降低散射中子占比,影锥法不适用于小尺寸中子参考辐射中对散射中子的修正;ARNR中的散射中子更少、占比更低,影锥法所得散射中子占比与理论值基本一致。 相似文献
95.
Yingzi Peng Dexuan Huo Liang Zheng Zhenghong Qian 《Particle & Particle Systems Characterization》2012,29(1):3-7
ZnO microstructures have been grown from zinc chloride (ZnCl2) and ammonia solution at 100 °C for 1 – 24 hours. X‐ray diffraction, scanning electron microscope and field‐emission scanning microscope were utilized to investigate the structural properties and morphology of the ZnO crystals. Structural investigations show that phase‐pure hexagonal structure ZnO has been successfully synthesized, and the hexagonal structure ZnO can be achieved in solutions with an appropriate range of concentrations. Under our experimental conditions, several different morphologies of ZnO structures were obtained, including flower‐like and bar flower‐like. The relationship between the morphology and experimental conditions are discussed. 相似文献
96.
本文使用傅里叶变换微波谱仪研究了乙基苯胺类物质(邻乙基苯胺,间乙基苯胺,对乙基苯胺)的分子结构. 由于此类分子含氮原子(I14N=1),因此跃迁谱线中都呈现出核四级裂分. 通过比较实验测定得到的分子结构,可总结苯胺环上不同位置乙基的取代对氨基及分子整体结构的影响. 相似文献
97.
POSITIVE DEFINITE PROBLEM OF ENERGY DENSITY AND RADIATIVE ENERGY FLUX FOR PULSE CYLINDRICAL GRAVITATIONAL WAVE 总被引:2,自引:0,他引:2 下载免费PDF全文
By using the general expressions of energy momentum pseudo-tensor of the cylin-drical gravitational waves (GW) given by Rosen and Virbhadra in Cartesian coor-dinates, the concrete forms of energy density and radiative energy flux of the pulse cylindrical GW are obtained. Their physical properties, suitable range and asymp-totic behaviour are considered. It is found that: For the region in which space radial coordinates to origin are greater than the pulse width of the pulse cylindrical GW, the energy density and radiative energy flux of the outward travelling pulse cylindrical GW propagating along at light-cone are positive definite. However, for the region in which the space radial coordinates are less than the pulse width, there is no guarantee for the positive definite property of the radiative energy flux of the outward travelling wave. Moreover, we show that the asymptotic behaviour of the energy and energy flux densities of the pulse cylindrical GW and that of the Riemann curvature tensor have good self-consistancy in space like, time like and null infinity regions. 相似文献
98.
The development direction of railways is toward the improvement of capacity and service quality, where the service quality includes safety, schedule, high speed, and comfort. In light of the existing cellular automaton models, in this paper, we develop a model to analyze the mixed running processes of trains with maximal speeds of 500 km/h and 350 km/h respectively in the moving block system. In the proposed model, we establish some sound rules to control the running processes of a train, where the rules include the departure rules in the intermediate stations, the overtaking rules, and the conditions of speed limitation for a train stopping at a station or passing through a station. With the consideration of the mixed ratio and the distance between two adjacent stations, the properties of the train traffic flow (including capacity and average speed) are simulated. The numerical results show that the interactions among different trains will affect the capacity, and a proper increase of the spatial distance between two adjacent stations can enhance the capacity and the average speed under the moving block. 相似文献
99.
This paper is concerned with the Hopf bifurcation control of a new hyperchaotic circuit system. The stability of the hyperchaotie circuit system depends on a selected control parameter is studied, and the critical value of the system parameter at which Hopf bifurcation occurs is investigated. Theoretical analysis give the stability of the Hopf bifurcation. In particular, washout filter aided feedback controllers are designed for delaying the bifurcation point and ensuring the stability of the bifurcated limit cycles. An important feature of the control laws is that they do not result in any change in the set of equilibria. Computer simulation results are presented to confirm the analytical predictions. 相似文献
100.
黄芩中锗的分光光度研究 总被引:4,自引:0,他引:4
对黄芩中的锗进行了分光光度法研究,结果表明,黄芩中含有丰富的有机锗。本方法简单可靠,可获得满意的分析结果。 相似文献