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951.
952.
Y Yuda J Tanaka K Suzuki K Igarashi T Satoh 《Chemical & pharmaceutical bulletin》1991,39(4):1075-1077
Effects of non-steroidal anti-inflammatory drugs (NSAID: amfenac sodium, diclofenac sodium, indomethacin and ketoprofen) on the generation of superoxide anion (O2-) by isolated rat polymorphonuclear leukocytes (PMN) were studied spectrophotometrically using cytochrome c. The effects of these drugs were also studied on O2- production by the xanthine-xanthine oxidase and reduced nicotinamide adenine dinucleotide phosphate (NADPH)-NADPH oxidase systems. Amfenac sodium, at 0.1 mM, inhibited significantly O2- generation in rat PMN induced by opsonized zymosan. At 0.5 mM, diclofenac sodium and indomethacin inhibited the O2- generation in rat PMN. All of the above drugs slightly inhibited O2- production by the xanthine-xanthine oxidase system. On the other hand, O2- production by the NADPH-NADPH oxidase system was significantly inhibited by the addition of amfenac sodium, ketoprofen or indomethacin. These results suggest that non-steroidal anti-inflammatory drugs do not work as an O2- scavenger and block O2- production by the NADPH-NADPH oxidase system of rat PMN. It is concluded that amfenac sodium and the other drugs are able to inhibit granulocyte O2- production by blocking the activation of NADPH-oxidase. 相似文献
953.
954.
A method is described for the determination of selenium, based on its catalytic effect on the picrate—sulfide reaction. The determination involves a variable-time kinetic procedure using potentiometric monitoring with a picrate-selective electrode and automatic measurement of the time required for the potential to change by a preselected amount (5.0 mV). Selenium in the range 3–30 μg was determined with an average error of about 4% and relative standard deviations of about 2%. The reaction can also be followed spectrophotometrically. 相似文献
955.
Mesoionic compounds with a bridged nitrogen atom. 4. Thiazolo[3, 2-a]quinolinium 1-oxide derivatives
L. T. Gorb A. D. Kachkovskii N. N. Romanov I. S. Shpileva A. I. Tolmachev 《Chemistry of Heterocyclic Compounds》1980,16(5):478-483
It is shown that diverse 2-substituted thiazolo[3,2-a]quinolinium 1-oxides can be obtained from 2-quinolylmercaptoacetic acids. The structures of the synthesized compounds were confirmed by the PMR and mass spectra.See [1] for communication 3.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 621–626, May, 1980. 相似文献
956.
957.
958.
Appleby I Boulton LT Cobley CJ Hill C Hughes ML de Koning PD Lennon IC Praquin C Ramsden JA Samuel HJ Willis N 《Organic letters》2005,7(10):1931-1934
Two methods to produce (2S)-5-amino-2-(1-n-propyl-1H-imidazol-4-ylmethyl)-pentanoic acid were investigated. Diastereoisomeric salt resolution, using the quinidine salt, gave the desired intermediate in 98% ee and 33% yield. Asymmetric hydrogenation of various substrates gave high conversions, with up to 83% ee. Integration of these two approaches via asymmetric hydrogenation of a quinidine salt substrate followed by crystallization provided the desired intermediate in 94% ee and 76% yield. 相似文献
959.
Faull KF Johnson J Kim MJ To T Whitelegge JP Stevens RL Fluharty CB Fluharty AL 《Journal of mass spectrometry : JMS》2000,35(12):1416-1424
The specific sugar residues and their linkages in the oligosaccharides from pig kidney and human urine cerebroside sulfate activator proteins (saposin B), although previously hypothesized, have been unambiguously characterized. Exhaustive sequential exoglycosidase digestion of the trimethyl-p-aminophenyl derivatives, followed by either matrix-assisted laser desorption/ionization and/or mass spectrometry, was used to define the residues and their linkages. The oligosaccharides were enzymatically released from the proteins by treatment with peptidyl-N-glycosidase F and separated from the proteins by reversed-phase high-performance liquid chromatography (HPLC). Reducing termini were converted to the trimethyl-p-aminophenyl derivative and the samples were further purified by normal-phase HPLC. The derivatized carbohydrates were then treated sequentially with a series of exoglycosidases of defined specificity, and the products of each digestion were examined by mass spectrometry. The pentasaccharides from pig kidney and human urine protein were shown to be of the asparagine-linked complex type composed of mannose-alpha 1-6-mannose-beta 1-4-N-acetylglucosamine-N-acetylglucosamine(alpha 1-6-fucose). This highly degraded structure probably represents the final product of intra-lysosomal exoglycosidase digestion. Oligosaccharide sequencing by specific exoglycosidase degradation coupled with mass spectrometry is more rapid than conventional oligosaccharide sequencing. The procedures developed will be useful for sequencing other oligosaccharides including those from other members of the lipid-binding protein class to which cerebroside sulfate activator belongs. (c) 2000 John Wiley & Sons, Ltd. 相似文献
960.
I. D. Shingarova I. V. Yartseva M. P. Nemeryuk A. L. Sedov T. S. Safonova G. A. Osipov Yu. Yu. Volodin M. N. Preobrazhenskaya 《Chemistry of Heterocyclic Compounds》1984,20(11):1287-1294
1-Nucleosides of 5-substituted 4-chloro-1,2,3-triazoles were produced by glycosylation of the corresponding triazoles by the method of fusion with tetra-0-acyl-D-ribofuranose in the presence of bis-p-nitrophenyl phosphate. The structure of the compounds obtained and their conformational peculiarities were studied by the methods of mass spectrometry and NMR spectroscopy.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 11, pp. 1556–1564, November, 1984. 相似文献