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101.
Hicks JW VanBrocklin HF Wilson AA Houle S Vasdev N 《Molecules (Basel, Switzerland)》2010,15(11):8260-8278
Imaging protein kinase expression with radiolabeled small molecule inhibitors has been actively pursued to monitor the clinical potential of targeted therapeutics and treatments as well as to determine kinase receptor density changes related to disease progression. The goal of the present review is to provide an overview of the breadth of radiolabeled small molecules that have been synthesized to target intracellular protein kinases, not only for imaging in oncology, but also for other areas of interest, particularly the central nervous system. Considerable radiotracer development has focused on imaging receptor tyrosine kinases of growth factors, protein kinases A, B and C, and glycogen synthase kinase-3?. Design considerations, structural attributes and relevant biological results are summarized. 相似文献
102.
Dr. Sylvain Antoniotti Prof. Dr. Vincent Dalla Dr. Elisabet Duñach 《Angewandte Chemie (International ed. in English)》2010,49(43):7860-7888
The continuously increasing need for novel and selective methods in organic synthesis to aid drug discovery and to address environmental concerns is a constant source of stimulation to develop novel and more efficient reaction systems. This has often resulted in a focus on transition metals, ligands, and additives, with much less attention paid to the counterion(s) of the metal cation. Recently, metal salts with one or more triflimidate counterion(s) have appeared as a unique class of catalysts that display outstanding σ‐ and π‐Lewis acid character. The highly delocalized nature of the triflimidate counterion, combined with its high steric hindrance results in virtually no nucleophilic behavior and an extremely high positive charge density on the metal cation, thus enhancing its Lewis acid character. Consequently, these metal triflimidates often outperform their metal halide or triflate analogues. This Review describes general methods for the preparation of metal triflimidate salts and their use as catalysts. 相似文献
103.
Nun P Gaillard S Slawin AM Nolan SP 《Chemical communications (Cambridge, England)》2010,46(48):9113-9115
The use of [(IPr)AuOH] permits the generation of gold(i)-amine complexes by a silver-free protocol. These in situ or well-defined complexes are used in a straightforward synthetic route to substituted allenes from propargylic acetates. The catalytic activity can be modulated as a function of the nature of the ligand bound to the gold-NHC moiety. 相似文献
104.
Aline Staub Sylvain Giraud Martial Saugy Serge Rudaz Jean‐Luc Veuthey Julie Schappler 《Electrophoresis》2010,31(2):388-395
CE is a powerful analytical tool used to separate intact biomolecules such as proteins. The coupling of CE with TOF/MS produces a very promising method that can be used to detect and identify proteins in different matrices. This paper describes an efficient, rapid, and simple CE‐ESI‐TOF/MS procedure for the analysis of endogenous human growth hormone and recombinant human growth hormone without sample preparation. Operational factors were optimized using an experimental design, and the method was successfully applied to distinguish human growth hormone and recombinant human growth hormone in unknown samples. 相似文献
105.
d'Alessandro C Rilliard A Le Beux S 《The Journal of the Acoustical Society of America》2011,129(3):1594-1604
Intonation stylization is studied using "chironomy," i.e., the analogy between hand gestures and prosodic movements. An intonation mimicking paradigm is used. The task of the ten subjects is to copy the intonation pattern of sentences with the help of a stylus on a graphic tablet, using a system for real-time manual intonation modification. Gestural imitation is compared to vocal imitation of the same sentences (seven for a male speaker, seven for a female speaker). Distance measures between gestural copies, vocal imitations, and original sentences are computed for performance assessment. Perceptual testing is also used for assessing the quality of gestural copies. The perceptual difference between natural and stylized contours is measured using a mean opinion score paradigm for 15 subjects. The results indicate that intonation contours can be stylized with accuracy by chironomic imitation. The results of vocal imitation and chironomic imitation are comparable, but subjects show better imitation results in vocal imitation. The best stylized contours using chironomy seems perceptually indistinguishable or almost indistinguishable from natural contours, particularly for female speech. This indicates that chironomic stylization is effective, and that hand movements can be analogous to intonation movements. 相似文献
106.
Gillard F Lefebvre S Ferrec Y Mugnier L Rommeluère S Benoit C Guérineau N Taboury J 《Optics letters》2011,36(13):2444-2446
A design of a miniaturized stationary Fourier transform IR spectrometer has been developed that produces a two-dimensional interferogram. The latter is disturbed by effects like parasitic interferences or disparities in the cutoff wavelength of the pixels. Thus, a simple Fourier transform cannot be used to estimate the spectrum of the scene. However, as these defects are deterministic, they can be measured and taken into account by inversion methods. A regularization term can also be added. The first experimental results prove the efficiency of this processing methodology. 相似文献
107.
Sandra Cruz Sylvain Bernès Pankaj Sharma Rosa Vazquez Guadalupe Hernández Roberto Portillo René Gutiérrez 《应用有机金属化学》2010,24(1):8-11
Optically pure α‐diimines quantitatively obtained in solvent‐free conditions starting from 2,3‐butanedione and (S)‐(?)‐1‐phenylethylamine and (S)‐(?)‐1‐(4‐methylphenyl)ethylamine, respectively, yielded the new chiral mono‐Pd complexes 2a–b, which have been partly characterized by IR, 1H‐ and 13C‐NMR spectroscopies along with MS‐FAB+ spectrometry. The crystal and molecular structure for palladacycle 2a has been fully confirmed by single‐crystal X‐ray studies. Studies in vitro of 2a–b have displayed growth inhibition against different classes of cancer: leukemia (K‐562 CML), colon cancer (HCT‐15), breast cancer (MCF‐7), central nervous system (U‐251 Glio) and prostate cancer (PC‐3) cell lines. Copyright © 2009 John Wiley & Sons, Ltd. 相似文献
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In this Note, we present a new formalism for nonlinear and non-separable multiscale representations. The new formalism we propose brings about similarities between existing nonlinear multiscale representations and also allows us to alleviate the classical hypotheses made to prove the convergence of the multiscale representations. 相似文献