An in vitro study of the hydroxyl radical scavenging property of fluvastatin, and HMG-CoA reductase inhibitor.

We investigated the in vitro hydroxyl radical scavenging activity of fluvastatin, a 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitor. Fluvastatin showed hydroxyl radical scavenging activity as potent as that of dimethylthiourea and alpha-tocopherol, which are well-known respectively, as a hydroxyl radical scavenger and a natural antioxidant. Since this effect was not observed in other HMG-CoA reductase inhibitors, such as pravastatin and simvastatin, the scavenging effect of fluvastatin on hydroxyl radicals would not be a common property of HMG-CoA reductase inhibitors, but is derived from the unique chemical structure of fluvastatin. The hydroxyl radical scavenging activities of human metabolites of fluvastatin were also determined. All the tested metabolites possessing the fluorophenyl indole moiety showed activity. Among them, the metabolites which possess a phenolic hydroxyl group on the indole moiety showed stronger effects than that of fluvastatin. We suggest that the fluorophenyl indole moiety of fluvastatin is important for manifestation of the activity and that the phenolic hydroxyl group enhances the potency.     

Pairing in one-dimensional antiferromagnetic superconductors in the presence of a homogeneous magnetic field

Assuming a one-dimensional like electron band and considering the free energy difference δF(= F_s?F_N) near the second order phase transition temperature, it is shown that for an antiferromagnetic superconductor in a homogeneous magnetic field (howsoever weak) the minimum of δF occurs when the state with spatially varying order parameter (having same period as the antiferromagnetic ordering) coexists with the usual BCS state.     

Metal triflimide as a Lewis acid catalyst for Biginelli reactions in water

Metal triflimides such as Ni(NTf₂)₂, Cu(NTf₂)₂ and Yb(NTf₂)₃ catalyzed the Biginelli reaction to afford 3,4-dihydropyrimidin-2(1H)-ones more efficiently in pure water at room temperature than did corresponding metal triflate salts.