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91.
92.
A. L. Carey H. Grundling I. Raeburn C. Sutherland 《Communications in Mathematical Physics》1995,168(2):389-416
We study group extensions , where acts on a C*-algebraA. Given a twisted covariant representation ,V of the pairA, we construct 3-cocycles on with values in the centre of the group generated byV(). These 3-cocycles are obstructions to the existence of an extension of byV() which acts onA compatibly with . The main theorems of the paper introduce a subsidiary invariant which classifies actions of onV() and in terms of which a necessary and sufficient condition for the the cohomology class of the 3-cocycle to be non-trivial may be formulated. Examples are provided which show how non-trivial 3-cocycles may be realised. The framework we choose to exhibit these essentially mathematical results is influenced by anomalous gauge field theories. We show how to interpret our results in that setting in two ways, one motivated by an algebraic approach to constrained dynamics and the other by the descent equation approach to constructing cocycles on gauge groups. In order to make comparisons with the usual approach to cohomology in gauge theory we conclude with a Lie algebra version of the invariant and the 3-cocycle. 相似文献
93.
94.
The synthesis and characterization of the ion channel activity of three new bola-amphiphiles is described. These compounds are conceptually derived from a previously reported bis-cyclophane bola-amphiphile through opening of the cyclophanes to acyclic structures and were found to readily form ion channels in planar bilayer membranes as assessed by bilayer clamp single-channel analysis. All three compounds behaved very similarly: the dominant channels formed by all three are Ohmic with specific conductance of 10 +/- 1 pS (NaCl electrolyte) and 39 +/- 1 pS (CsCl electrolyte). Single-ion permeability ratios, determined from dissymmetric electrolyte experiments, showed the selectivity P(Cs(+)) > P(Na(+)) > P(Cl(-)). Less frequently, lower conductance channels were also observed to act independently of the dominant channels. The lifetimes of the dominant channels range from 70 to 280 ms for the three compounds with some very long-lived openings (20-40 s) observed for two of the three. The lower conductance states have shorter lifetimes. This study demonstrates that bis-macrocyclic compounds are not essential for channel formation by bola-amphiphiles, and opens a new class of channel-forming compounds for structure-activity optimization. 相似文献
95.
96.
Sutherland JC 《Photochemistry and photobiology》2002,76(2):164-170
Predicting the effects of polychromatic light on biological systems is a central goal of environmental photobiology. If the dose-response function for a process is a linear function of the light incident on a system at each wavelength within the spectrum, the effect of a polychromatic spectrum is obtained by integrating the product of the cross section for the reaction at each wavelength and the spectral irradiance at that wavelength over both wavelength and time. This procedure cannot be used, however, if the dose-response functions for an effect are not linear functions of photon dose. Although many photochemical reactions are linear within the biologically relevant range of doses, many biological end points are not. I describe procedures for calculating the effects of polychromatic irradiations on systems that exhibit certain classes of dose-response functions, including power law responses typical of mutation induction and exponential dose-responses typical of cell survival. I also present an approach to predict the effects of polychromatic spectra on systems in which the ultraviolet components form pyrimidine dimers, and the longer-wavelength ultraviolet and visible components remove them by photoreactivation, thus generating complex dose-response functions for these coupled light-driven reactions. 相似文献
97.
Haim Hacham Steven E. Freeman Richard W. Gange Daniel J. Maytum John C. Sutherland Betsy M. Sutherland † 《Photochemistry and photobiology》1990,52(4):893-896
A previous report [Freeman et al. (1986) Photochem. Photobiol. 43S, 93S] indicated that irradiation of human skin in situ with 385 or 405 nm radiation produced detectable levels of pyrimidine dimers in DNA. Since these wavelengths are absorbed poorly by DNA, these results suggested that DNA damage was sensitized by other absorbing molecules present in skin. Examination of two experimental aspects of the previous work indicates that (1) the static gel electrophoresis method for DNA dispersion used in lesion determination gave accurate values of the levels of induced dimers, and (2) the DNA damage apparently induced by 385 nm was actually induced by shorter wavelength UV present in the 20 nm bandpass beam of the monochromator. The current results indicate that monochromatic 385 and 405 nm radiation are ineffective in dimer production in human skin in situ. 相似文献
98.
New (tetrakis)imidazolium macrocyclic receptor systems of variable cavity size have been synthesised by stepwise alkylation reactions of bis(imidazolium) precursor compounds. Proton NMR titration studies reveal the macrocycles to strongly bind halide and benzoate anions, with two receptor systems displaying notable selectivity for fluoride in competitive acetonitrile-water (9:1) solvent media. 相似文献
99.
100.
Ronald G. Sutherland Alaa S. Abd-El-Aziz Adam Pirko Udai S. Gill Choi Chuck Lee 《Journal of heterocyclic chemistry》1988,25(4):1107-1110
An efficient synthesis of 3-mono or 3,4-disubstituted cinnolines from (o-dichlorobenzene)(cyclopentadienyl)iron hexafluorophosphate in three or four steps has been achieved. o-Chlorophenyl-alkyl or alkylaryl ketone complexes obtained from the o-dichlorobenzene complex upon treatment with enolate anions, react with hydrazine forming 3-mono or 3,4-disubstituted 1,4-dihydrocinnoline complexes. Treatment of the later with sodium amide leads to an aromatization-demetallation reaction resulting in formation of cinnolines, i.e. 3-methyl-, 3-phenyl- and 3,4-dimethylcinnoline. The influence of substituents bonded to the carbon atom adjacent to the complexed benzene ring in o-chlorophenyl -alkyl or -alkylaryl ketone prior to cyclization on the cyclization reaction is discussed. 相似文献