全文获取类型
收费全文 | 1802篇 |
免费 | 62篇 |
国内免费 | 11篇 |
专业分类
化学 | 1412篇 |
晶体学 | 22篇 |
力学 | 61篇 |
数学 | 112篇 |
物理学 | 268篇 |
出版年
2024年 | 3篇 |
2023年 | 8篇 |
2022年 | 34篇 |
2021年 | 50篇 |
2020年 | 39篇 |
2019年 | 47篇 |
2018年 | 45篇 |
2017年 | 44篇 |
2016年 | 82篇 |
2015年 | 60篇 |
2014年 | 109篇 |
2013年 | 156篇 |
2012年 | 135篇 |
2011年 | 153篇 |
2010年 | 83篇 |
2009年 | 62篇 |
2008年 | 107篇 |
2007年 | 112篇 |
2006年 | 89篇 |
2005年 | 89篇 |
2004年 | 53篇 |
2003年 | 47篇 |
2002年 | 44篇 |
2001年 | 12篇 |
2000年 | 16篇 |
1999年 | 10篇 |
1998年 | 19篇 |
1997年 | 12篇 |
1996年 | 15篇 |
1995年 | 12篇 |
1994年 | 10篇 |
1993年 | 5篇 |
1992年 | 7篇 |
1991年 | 13篇 |
1990年 | 4篇 |
1989年 | 5篇 |
1988年 | 4篇 |
1987年 | 8篇 |
1985年 | 10篇 |
1984年 | 9篇 |
1982年 | 5篇 |
1981年 | 5篇 |
1980年 | 7篇 |
1979年 | 4篇 |
1978年 | 5篇 |
1977年 | 3篇 |
1976年 | 5篇 |
1975年 | 3篇 |
1969年 | 2篇 |
1964年 | 5篇 |
排序方式: 共有1875条查询结果,搜索用时 10 毫秒
41.
Vasu Govardhana Reddy P Suresh Reddy C Naga Raju C 《Chemical & pharmaceutical bulletin》2003,51(7):860-863
N-(substituted)-N'-(2,3-dihydro-5-benzoyl-2-oxido-1H-1,3,2-benzodiazaphosphol-2-yl) ureas were synthesized by reacting 3,4-diaminobenzophenone (4) with different chlorides of carbamidophosphoric acids (3) in the presence of triethylamine at 40-45 degrees C. Their 1H-, 13C- and 31P-NMR spectral data are discussed. The title compounds were screened for antifungal and antibacterial activity against the fungi Aspergillus niger and Fusarium solani and bacteria Escherichia coli and Staphylococcus aureus. These compounds showed higher antibacterial activity when compared with antifungal activity. 相似文献
42.
Kanchi Suvardhan Kailasa Suresh Kumar Dasari Rekha Pantrangam Subrahmanyam Kapuvedi Kiran Bellum Jayaraj Surasura Ramanaiah Kandhukuri Janardhanam Pattium Chiranjeevi 《Mikrochimica acta》2007,157(3-4):237-244
Cloud point extraction was applied as a method for preconcentration of rhodium after formation of a complex with 2-propylpiperidine-1-carbodithioate
(2-PPC), and later determined by flame atomic absorption spectrometry using TritonX-114 as surfactant. Rhodium was complexed
with 2-PPC in an aqueous phase and kept for 15 min in a thermostatted bath at 40 °C. Separation of the two phases was accomplished
by centrifugation for 15 min at 4000 rpm. The chemical variables affecting the cloud point extraction were optimized and successfully
applied to rhodium determination in various water samples. Under optimized conditions, the preconcentration system (100 mL
sample) permitted an enhancement factor of 50. The detection limits obtained under optimal conditions was 0.052 ng mL−1. The extraction efficiency was investigated at different rhodium concentrations (7.0–42.0 μg mL−1), and good recoveries (96.42–99.14%) were obtained using this method. It has been applied to the determination of rhodium
in water and was compared with reported methods in terms of Student’s ‘t’-test and variance ratio ‘f’-test. 相似文献
43.
Awale S Tezuka Y Banskota AH Adnyana IK Kadota S 《Chemical & pharmaceutical bulletin》2003,51(3):268-275
From the methanolic extract of Indonesian Orthosiphon stamineus, nine new highly-oxygenated isopimarane-type diterpenes [7-O-deacetylorthosiphol B (1), 6-hydroxyorthosiphol B (2), 3-O-deacetylorthosiphol I (3), 2-O-deacetylorthosiphol J (4), siphonols A-E (5-9)] have been isolated together with nine known diterpenes [orthosiphols H (10), K (11), M (12) and N (13); staminols A (14) and B (15); neoorthosiphols A (16) and B (17); norstaminol A (18)]. Their structures were determined based on the spectroscopic data. The isolated diterpenes inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-activated macrophage-like J774.1 cells. Compounds 4-7, 9, 10, 14, and 17 showed inhibitory activities more potent (IC(50), 10.8-25.5 microM) than a positive control N(G)-monomethyl-L-arginine (L-NMMA; IC(50), 26.0 microM). 相似文献
44.
Amphiphilic and hydrophilic oligomers were synthesized and coated on fused silica capillaries using a sol-gel technique. Sol-gel-coated capillaries were evaluated for the solid-phase microextraction and preconcentration of a wide variety of non-polar and polar analytes. Both types of coatings were stable under high temperature (up to 280 degrees C). The extraction efficiency of the sol-gel coatings was evaluated for the extraction of both non-polar and polar analytes, including organochlorine pesticides, triazine herbicides, estrogens and alkylphenols (APs) and bisphenol-A (BPA). Compared with commercially available solid-phase microextraction (SPME) adsorbents such as poly(dimethylsiloxane)divenylbenzene and polyacrylate, the new materials showed comparable selectivity and sensitivity towards both non-polar and polar analytes. The new coatings gave good linearity and detection limits. For example with triazines, a detection limit of <0.005 microl l(-1), precision from 5.0 to 11.0% (n = 6) and linearity of the calibration plots (0.5 to 50 microl l(-1)) were obtained. The sol-gel coated SPME capillaries were used for the determination of triazine herbicides in reservoir water samples collected in Singapore. 相似文献
45.
Matthew N. Idso Ajay Suresh Akhade Mario L. Arrieta-Ortiz Bert T. Lai Vivek Srinivas James P. Hopkins Jr. Ana Oliveira Gomes Naeha Subramanian Nitin Baliga James R. Heath 《Chemical science》2020,11(11):3054
Antibiotic resistant infections are projected to cause over 10 million deaths by 2050, yet the development of new antibiotics has slowed. This points to an urgent need for methodologies for the rapid development of antibiotics against emerging drug resistant pathogens. We report on a generalizable combined computational and synthetic approach, called antibody-recruiting protein-catalyzed capture agents (AR-PCCs), to address this challenge. We applied the combinatorial protein catalyzed capture agent (PCC) technology to identify macrocyclic peptide ligands against highly conserved surface protein epitopes of carbapenem-resistant Klebsiella pneumoniae, an opportunistic Gram-negative pathogen with drug resistant strains. Multi-omic data combined with bioinformatic analyses identified epitopes of the highly expressed MrkA surface protein of K. pneumoniae for targeting in PCC screens. The top-performing ligand exhibited high-affinity (EC50 ∼50 nM) to full-length MrkA, and selectively bound to MrkA-expressing K. pneumoniae, but not to other pathogenic bacterial species. AR-PCCs that bear a hapten moiety promoted antibody recruitment to K. pneumoniae, leading to enhanced phagocytosis and phagocytic killing by macrophages. The rapid development of this highly targeted antibiotic implies that the integrated computational and synthetic toolkit described here can be used for the accelerated production of antibiotics against drug resistant bacteria.Antibody-recruiting protein-catalyzed capture agent (AR-PCCs) are a new class of all-synthetic and highly targeted antibiotics that recruit endogenous immune responses to eliminate drug-resistant microbes. 相似文献
46.
An intercrosslinked network of cyanate ester (CE)-bismaleimide (BMI) modified epoxy matrix system was made by using epoxy resin, 1,3-dicyanatobenzene and bismaleimide (N,N′-bismaleimido-4,4′-diphenyl methane) with diaminodiphenylmethane as curing agent. BMI-CE-epoxy matrices were characterised using differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and heat deflection temperature (HDT) analysis. The matrices, in the form of castings, were characterised for their mechanical properties such as tensile strength, flexural strength and unnotched Izod impact test as per ASTM methods. Mechanical studies indicated that the introduction of cyanate ester into epoxy resin improves the toughness and flexural strength with reduction in tensile strength and glass transition temperature, whereas the incorporation of bismaleimide into epoxy resin influences the mechanical and thermal properties according to its percentage content. DSC thermograms of cyanate ester as well as BMI modified epoxy resin show an unimodal reaction exotherm. Electrical properties were studied as per ASTM method and the morphology of the BMI modified epoxy and CE-epoxy systems were studied by scanning electron microscope. 相似文献
47.
Suresh Maddila Nagaraju Kerru Sreekantha Babu Jonnalagadda 《Molecules (Basel, Switzerland)》2022,27(19)
Pyrans are one of the most significant skeletons of oxygen-containing heterocyclic molecules, which exhibit a broad spectrum of medicinal applications and are constituents of diverse natural product analogues. Various biological applications of these pyran analogues contributed to the growth advances in these oxygen-containing molecules. Green one-pot methodologies for synthesising these heterocyclic molecules have received significant attention. This review focuses on the recent developments in synthesising pyran ring derivatives using reusable catalysts and emphasises the multicomponent reaction strategies using green protocols. The advantages of the catalysts in terms of yields, reaction conditions, and recyclability are discussed. 相似文献
48.
49.
Dr. Papri Sutar Dr. Vasudeva Rao Bakuru Pooja Yadav Subhajit Laha Dr. Suresh Babu Kalidindi Prof. Dr. Tapas Kumar Maji 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(10):3268-3272
The composite hydrogel of a nanoscale metal–organic framework (NMOF) and nanoclay has emerged as a new soft-material with advanced properties and applications. Herein, we report a facile synthesis of a hydrogel nanocomposite by charge-assisted self-assembly of Pd@ZIF-8 nanoparticles with Laponite® nanoclay which coat the surface of Pd@ZIF-8 nanoparticles. Such surface coating significantly enhanced the thermal stability of the ZIF-8 compared to the pristine framework. Further, the Pd@ZIF-8+LP hydrogel nanocomposite shows better size-selective catalytic hydrogenation of olefins than Pd@ZIF-8 nanoparticles based on selective diffusion of the substrate. 相似文献
50.