Synthesis of phthalimidines linked to quinoline derivatives by an amide bridge

Russian Chemical Bulletin - The reactions of 3-acetoxy-2-acetyl(cyanoacetyl)aminoisoindolin-1-one (1) with o-tosylaminobenzaldehyde and o-mesylaminobenzaldehyde morpholinals lead to a mixture of...     

Povarov Reaction of Glyoxylate Imines Derived from 12-Aminodehydroabietic Acid

Glyoxylate and arylglyoxal imines based on 12-aminodehydroabietic acid undergo hetero-Diels—Alder (Povarov) reaction with ethyl vinyl ether, cyclopentadiene, and indene to give, respectively, methyl (8aR,9R,12aS)-3-aroyl-5-isopropyl–9,12a-dimethyl–7,8,8a,9,10,11,12,12a-octahydronaphtho[1,2-f]quinoline-9-carboxylates, methyl (7R,10aS,10dR,13aS)-1-aroyl–3-isopropyl–7,10a-dimethyl–2,5,6,6a,7,8,9,10,10a,10d,13,13a-dodecahydro-1H-naphtho[1,2-f]cyclopenta[c]quinoline-7-carboxylates, and methyl (6aS,11bS,11eS,15R,15aR)-6-aroyl–4-isopropyl–11e,15-dimethyl–2,5,6,6a,7,11b,11e,12,13,14,15,15a-1H-dodecahydroindeno[2,1-c]-naphtho[1,2-f]quinoline-15-carboxylates.     

New derivatives obtained from ortho-isobornylphenols and 4,13-diaza-18-crown-6

New aminomethyl derivatives were synthesized via Mannich reaction of 4,13-diaza-18-crown-6 with racemic 2-isobornyl-4-methylphenol and 2-isobornylphenol. The diastereoisomers (meso-form and racemate) derived from the racemic terpenophenols were detected by the ¹³C NMR spectroscopy. The signals were assigned by comparison with the ¹³C NMR spectrum of the enantiomer of one of the derivatives. The optically active disubstituted diaza-crown-ether molecule was studied by the XRD analysis that showed the presence of the intramolecular hydrogen bonds.     

Synthesis of (5R*,6R*,7S*)-6-iodo-1,5,6,7-tetrahydro-4,1-benzoxazonin-3(2H)-ones

New 6-iodo-1,5,6,7-tetrahydro-3H-4,1-benzoxazonin-3-ones have been synthesized by reaction of N-tosyl- and N-(2-nitrobenzenesulfonyl)-N-[2-(alkenyl)phenyl]aminoacetic acids with molecular iodine.     

Transition metal complexes with 2,6-Di-tert-butyl-p-quinone 1′-phthalazinylhydrazone

2,6-Di-tert-butyl-p-quinone 1′-phthalazinylhydrazone (HL) was synthesized. Quantum-chemical calculations of the energy of possible tautomeric forms of the hydrazone were performed. The complexes of Zn(II), Hg(II), Ni(II), and Cu(II) of ML₂ composition were obtained and studied. The structure of the NiL₂ complex was established by XRD. It was shown by DFT-D3 calculations that the cis-structure of the complex is stabilized due to the interligand dispersion interaction.     

o-Bornylphenol: Stereochemistry and synthesis of new derivatives from its (+)-enantiomer

New derivatives of the (+)-enantiomer of o-bornylphenol were synthesized with a view to determine the configuration of chiral centers therein. The absolute configuration of the terpene substituents in the Mannich reaction product obtained from 4,13-diaza-18-crown-6 was estimated as (1R,2R,4S) on the basis of anomalous X-ray scattering.     

Effect of the nature of non-bridging donor atoms on the structure and magnetic properties of binuclear copper(II) complexes with heterocyclic azomethyne ligands

Journal of Structural Chemistry - Pyrazolate bridging binuclear copper(II) complex with a heterocyclic azomethyne ligand (a condensation product of 1,3-diaminopropanol-2 with...     

Self-similar problems of convective diffusion in the presence of heterogeneous chemical reactions with allowance for thermal diffusion effects

A number of studies have been made of the problem of the effect of a temperature gradient on mass transfer in a forced viscous fluid flow. The question of allowing for thermal diffusion effects has been examined in connection with flow around bodies [1–4], duct flow [5], and jet flows [6,7]. Recently, in addition to the problem of thermal diffusion separation, the attention of investigators has been claimed by the problem of taking into account the effect of thermal diffusion on mass transfer in a convective flow in the presence of chemical reactions on the flow surfaces [4].     

Synthesis and membrane-protective activity of 4-aminomethyl derivatives of 2,6-diisobornylphenol

A series of 4-aminomethyl derivatives of 2,6-diisobornylphenol containing tertiary and secondary amino groups were synthesized. Their toxicity and the membrane-protective and antioxidant activity were assessed using red blood cells of laboratory mice as the test object. These compounds were shown to exhibit high membrane-protective and antioxidant activity, which substantially depends on the structure of the substituent and the concentration of the substance.