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131.
Asymmetric Modulation of Protein Order–Disorder Transitions by Phosphorylation and Partner Binding
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Priya R. Banerjee Diana M. Mitrea Richard W. Kriwacki Ashok A. Deniz 《Angewandte Chemie (International ed. in English)》2016,55(5):1675-1679
As for many intrinsically disordered proteins, order–disorder transitions in the N‐terminal oligomerization domain of the multifunctional nucleolar protein nucleophosmin (Npm‐N) are central to its function, with phosphorylation and partner binding acting as regulatory switches. However, the mechanism of this transition and its regulation remain poorly understood. In this study, single‐molecule and ensemble experiments revealed pathways with alternative sequences of folding and assembly steps for Npm‐N. Pathways could be switched by altering the ionic strength. Phosphorylation resulted in pathway‐specific effects, and decoupled folding and assembly steps to facilitate disorder. Conversely, binding to a physiological partner locked Npm‐N in ordered pentamers and counteracted the effects of phosphorylation. The mechanistic plasticity found in the Npm‐N order–disorder transition enabled a complex interplay of phosphorylation and partner‐binding steps to modulate its folding landscape. 相似文献
132.
Dr. Anup Rana Yongseok Hong Dr. Tullimilli Y. Gopalakrishna Dr. Hoa Phan Dr. Tun Seng Herng Priya Yadav Prof. Jun Ding Prof. Dongho Kim Prof. Jishan Wu 《Angewandte Chemie (International ed. in English)》2018,57(38):12534-12537
The synthesis of a bithiophene‐bridged 34π conjugated aromatic expanded porphycene 1 and a cyclopentabithiophene bridged 32π conjugated anti‐aromatic expanded porphycene 2 by a McMurry coupling strategy is presented. Magnetic measurements and theoretical calculations reveal that both 1 and 2 exhibit an open‐shell singlet ground state with significant radical character (y0=0.63 for 1 ; y0=0.68, y1=0.18 for 2 ; y0: diradical character, y1: tetraradical character) and a small singlet–triplet energy gap (ΔES‐T=?3.25 kcal mol?1 for 1 and ΔES‐T=?0.92 kcal mol?1 for 2 ). Despite the open‐shell radical character, both compounds display exceptional stability under ambient air and light conditions owing to effective delocalization of unpaired electrons in the extended cyclic π‐conjugation pathway. 相似文献
133.
Jose Priya Parvathi Ameena Kala M. S. Kalarikkal Nandakumar Thomas Sabu 《Research on Chemical Intermediates》2018,44(9):5597-5621
Research on Chemical Intermediates - Dye effluents play a major role in polluting water bodies, and various treatment technologies are being used for their removal. Among these methods, green... 相似文献
134.
Sucrose chelated auto combustion synthesis of BiFeO3 nanoparticles: Magnetically recoverable catalyst for the one‐pot synthesis of polyhydroquinoline
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Sucrose chelated Bismuth ferrite (BiFeO3) nanoparticles as a novel heterogeneous catalyst was synthesized by an auto combustion route. Different calcination temperatures (150 °C, 450 °C, 550 °C, 650 °C, 750 °C and 850 °C) have been employed to obtain single phased BiFeO3 nanoparticles. The perovskite structure formation and disappearance of organic phase (sucrose) was obtained by Fourier transform infrared spectroscopy (FT‐IR). Phase determination and structural characterization was carried out by powder X‐ray diffraction (XRD). The magnetic properties were analyzed by vibrating sample magnetometer (VSM) whereas surface area/pore volume was obtained by Brunauer–Emmett–Teller (BET). Transmission electron microscope (TEM) analyzed the particles size and morphology. Thermal stability was investigated by thermogravimetric analysis (TGA) and determination of constituent elements was carried out by X‐ray Photo‐Electron Spectroscopy (XPS). Raman spectroscopy confirmed the perovskite structure of the synthesized materials. The BiFeO3 nanoparticles so obtained were employed as heterogeneous catalyst for the synthesis of polyhydroquinoline derivatives. All the polyhydroquinoline derivatives were characterized by Fourier transform infrared spectroscopy (FT‐IR) and Nuclear magnetic resonance spectroscopy (1H NMR). For the very first time ever we have used BiFeO3 as a recyclable magnetic nanocatalyst in the one‐pot four component cyclization reaction of benzaldehyde, ethylacetoacetate/methylacetoacetate, dimedone/cyclohexane‐1,3‐dione, and ammonium acetate for the synthesis of polyhydroquinoline derivatives without solvent under refluxing conditions to provide excellent yields of products. BiFeO3 nanocatalyst (without any functionalization/surface coatings) shows easy magnetic separation, recyclability, reusability along with excellent yield of polyhydroquinoline derivatives in an economic and benign way. 相似文献
135.
1-glycyl-3-methyl imidazolium chloride-copper (II) complex [[Gmim]Cl-Cu (II)] was found to be a heterogeneous catalyst for an efficient and greener solvent free synthesis of esters by condensation of carboxylic acids and alcohols with excellent yield with high turnover number (8.3 × 102 to 9.5 × 102) using ultrasound irradiation. In addition, this method features reusability of catalyst, reduced waste, thus making new protocol more environmentally suitable whilst no catalyst leaching was observed. 相似文献
136.
Priya Anbu Kadarkarai Murugan Pari Madhiyazhagan Devakumar Dinesh Jayapal Subramaniam Chellasamy Panneerselvam 《Natural product research》2016,30(18):2077-2084
The impact of green-synthesised mosquitocidal nanoparticles on non-target aquatic predators is poorly studied. In this research, we proposed a single-step method to synthesise silver nanoparticles (Ag NP) using the seed extract of Melia azedarach. Ag NP were characterised using a variety of biophysical methods, including UV–vis spectrophotometry, scanning electron microscopy, energy-dispersive X-ray spectroscopy and Fourier transform infrared spectroscopy. In laboratory assays on Anopheles stephensi, Ag NP showed LC50 ranging from 2.897 (I instar larvae) to 14.548 ppm (pupae). In the field, the application of Ag NP (10 × LC50) lead to complete elimination of larval populations after 72 h. The application of Ag NP in the aquatic environment did not show negative adverse effects on predatory efficiency of the mosquito natural enemy Cyclops vernalis. Overall, this study highlights the concrete possibility to employ M. azedarach-synthesised Ag NP on young instars of malaria vectors. 相似文献
137.
138.
Priya Verma Ritu Raj Bimalendu Roy Balaram Mukhopadhyay 《Tetrahedron: Asymmetry》2010,21(19):2413-2418
A concise synthesis of a tetrasaccharide related to the cell-growth inhibitory triterpenoid saponin isolated from Schima noronhae is reported. A late stage 2,2,6,6-tetramethylpiperidinyloxy (TEMPO)-mediated oxidation of a primary hydroxyl group to carboxylic acid has been achieved under phase-transfer conditions. Stereoselective glycosylations were carried out using thioglycoside or glycosyl trichloroacetimidate activation using sulfuric acid immobilized on silica (H2SO4–silica) in conjunction with N-iodosuccinimide and alone, respectively. 相似文献
139.
Zhao Tian Arunachalam Chinnathambi Tahani Awad Alahmadi Surapaneni Krishna Mohan Vishnu Priya Veeraraghavan Saravana Kumar Jaganathan 《Arabian Journal of Chemistry》2021,14(9):103293
Rheumatoid arthritis (RA) results in increased rate of mortality in millions of people worldwide. Research utilizing Tin oxide – Chitosan- Polyethylene glycol Carvacrol (SCP-CAR) nanocomposites has gained increased attention because of its multipotent properties and application in diverse fields including medicinal preparations. The aim of the investigation was to synthesize and to examine the anti-arthritic ability of SCP-CAR nanocomposites against CFA -induced RA in rats. Arthritis induction was done by injecting 0.1 ml of Complete Freund’s adjuvant (CFA) intradermally. Body weight, weight of organs, hind paw volumes and arthritis score was assessed and the levels of inflammatory modulators such as IL-6, IL-1β, IL-10, TNF-α, PGE2 and COX-2 was examined using assay kits. Lipid peroxidation status, antioxidant enzyme activities and levels of liver function enzymes were evaluated using standard procedures. Histopathological changes observed in hind limb of experimental animals were viewed under microscope using H& E staining. The SCP-CAR nanocomposites treated arthritic animals showed increased bodyweight and reduced hind paw volume, organ weight and arthritis score together with elevated antioxidants status and depleted proinflammatory cytokines. Histopathological observation also showed reduction in bone destruction and penetration of inflammatory cells following treatment with SCP-CAR nanocomposites. Thus, together the findings depict the anti-arthritic and anti-inflammatory potential of SCP-CAR nanocomposites suggesting that it could be used as potent therapeutic agent to treat animals against arthritis induced by CFA. 相似文献
140.
A series of new diamagnetic ruthenium(II) complexes of the type [RuCl(CO)(B)(L)] (where B = PPh3, AsPh3 or Py; L = monobasic tridentate Schiff base ligands derived from o‐aminophenol or o‐aminothiophenol with ethylacetoacetate or ethylbenzoylacetate) have been synthesized and these complexes were characterized by physico‐chemical and spectroscopic methods. Cyclic voltammograms of all the complexes show quasi‐reversible oxidation in the range 0.24–1.05 V and the quasi‐reversible reduction in the range ? 0.14 to ? 0.51 V. The observed redox potentials show little variation with respect to the replacement of triphenyl phosphine/arsine by pyridine. The complexes were tested as catalysts in the oxidation of primary and secondary alcohols using molecular oxygen at room temperature and also in C? C coupling reactions. Further, the antibacterial properties of the free ligands and their metal complexes were evaluated against certain bacteria such as Escherichia coli and Staphylococcus aureus. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献