排序方式: 共有67条查询结果,搜索用时 125 毫秒
61.
Ajay K. Bose Maghar S. Manhas Subhendu N. Ganguly Suhas Pednekar Arun Mandadi 《Tetrahedron letters》2005,46(17):3011-3013
A water-based biphasic reaction process has been developed for conducting exothermic reactions without organic solvents. This procedure is rapid, simple, and suitable for small scale synthesis as well as larger (multi-molar) scale reactions. The preparation of several hundred grams of clofibric acid and analogues by this eco-friendly and energy-efficient procedure is described. Smaller amounts of these compounds were prepared by the friction-activated ‘Grindstone Chemistry’ method described previously. 相似文献
62.
The selective addition of arylmethylmagnesium halides with formaldehyde giving arylethyl alcohols is extremely challenging. To circumvent the difficulties, in the current communication, we have reported on the nucleophilic addition of benzyl zinc reagents derived from inexpensive and abundant benzyl chlorides to paraformaldehyde. The reaction investigated herein is hitherto unknown and was found to be selective, operationally simple, atom- and step-economical and high yielding to deliver phenethyl alcohols utilized as key perfumery ingredients in 60–83% yields. After successful establishment of the reaction condition, the reaction was also scaled up successfully to deliver a large-scale preparation of the phenethyl alcohol. 相似文献
63.
Babasaheb P. Bandgar Suhas P. Kasture 《Monatshefte für Chemie / Chemical Monthly》2001,8(2):1101-1104
Trimethylsilylation of alcohols and phenols is carried out using hexamethyldisilazane and LiClO4 under microwave irradiation and neutral conditions. The deprotection of silyl ethers is carried out similarly using natural kaolinitic clay and a few drops of water. 相似文献
64.
A comparative study on the adsorption of methylphenols on adsorbents prepared from several industrial wastes has been carried out. The results show that extent of adsorption on carbonaceous adsorbent prepared from fertilizer industry waste has been found to be 37.3, 40.5, 65.9, and 88.5 mg/g for 2-methylphenol, 4-methylphenol, 2,4-dimethylphenol, and 2,4,6-trimethylphenol, rspectively. As compared to carbonaceous adsorbent, the other three adsorbents viz. blast furnace sludge, dust, and slag adsorb methylphenols to a much smaller extent. This has been accounted for due to the carbonaceous adsorbent having a larger porosity and consequently higher surface area. The adsorption of phenols on this carbonaceous adsorbent as a function of contact time, concentration, and temperature has been studied by the batch method. The adsorption has been found to be endothermic and data conform to the Langmuir equation. The analysis of data indicates that adsorption is a first-order process and pore diffusion-controlled. The efficiency of the carbonaceous adsorbent was assessed by comparing the results with those on a standard activated charcoal sample. It was found that the carbonaceous adsorbent is about 45% as efficient as standard activated charcoal and can therefore be employed for the removal of methylphenols from wastewaters. 相似文献
65.
Chavan SA Maes W Gevers LE Wahlen J Vankelecom IF Jacobs PA Dehaen W De Vos DE 《Chemistry (Weinheim an der Bergstrasse, Germany)》2005,11(22):6754-6762
The convergent synthesis of a series of porphyrin-functionalized pyrimidine dendrimers has been accomplished by a procedure involving the nucleophilic aromatic substitution (NAS) as a key reaction step. The resulting dendritic porphyrin catalysts show high activity in the light-induced generation of singlet oxygen ((1)O2) from ground-state oxygen. These materials are synthetically useful photosensitizers for the oxidation of various olefinic compounds to the corresponding allylic hydroperoxides. Catalytic activities and regio- and stereoselectivities of the dendritic photosensitizers are comparable to those observed for mononuclear porphyrin catalysts. Recycling of the dendrimer-enlarged homogeneous photocatalysts was possible by solvent-resistant nanofiltration (SRNF) by using an oxidatively stable membrane consisting of a polysiloxane polymer and ultrastable Y zeolite as inorganic filler. Moreover, this membrane technology provides a safe way to isolate the hydroperoxide products under very mild conditions. The membrane showed high retention for the macromolecular catalysts, even in chlorinated solvents, but some oxidative degradation of the porphyrin units of the dendrimer was observed over multiple catalytic runs. 相似文献
66.
Sonawane S Chaudhari P Ghodke S Ambade S Gulig S Mirikar A Bane A 《Ultrasonics sonochemistry》2008,15(6):1033-1037
Sorption of phenol onto organophilic bentonite (nanoclay) by ultrasonic irradiation was investigated. Tetrabutyl ammonium chloride (TBAC), N-acetyl-N,N,N trimethyl ammonium bromide (CTAB) and hexadecyl trimethyl ammonium chloride (HDTMA) were used as intercalating agents. Nanoclay was synthesized using sonication technique. TBAC modified nanoclay shows amorphous exfoliated nature, while CTAB and HDTMA modified nanoclay shows intercalating crystalline nature, which was revealed by XRD gram. Further FTIR reveals the presence of NH(2) and (CH(2))(n) groups onto clay platelet. Due to sonication, adsorption equilibrium was achieved within short period of time (10 min). It was found that intraparticle diffusion resistance has overcome due to sonication. The experimental data obtained obeys both Freundlich isotherm model and Langmuir adsorption isotherm model. HDTMA modified nanoclay shows higher parameter values. 相似文献
67.
Dash RC Bhosale SH Shelke SM Suryawanshi MR Kanhed AM Mahadik KR 《Molecular diversity》2012,16(2):367-375
The dopamine D(2) receptor is involved in the etiology of a number of disorders, such as Parkinson's disease, Huntington's Chorea, tardive dyskinesia and schizophrenia. Antagonism of D(2) receptors is implicated in the treatment of various psychiatric disorders. In order to understand essential structural features required for D(2) antagonism, this research article elaborates on the generation of a four-point 3D pharmacophore model which was extracted from a series of 45 novel 3-[[(aryloxy)alkyl]piperidinyl]-1,2-benzisoxazole derivatives. The best pharmacophore model generated consisted of four PRRR features: a positively charged group (P), and three aromatic rings (R). Based on the model generated, a statistically valid 3D-QSAR with good predictability (Q(2) = 0.756) was derived. For the validation of the pharmacophore hypothesis, active compounds were docked against the 3D structure of the D(2) receptor which was constructed through homology modeling. Further, the derived pharmacophore was used as a query to search the Zinc 'clean drug-like' database. Hits retrieved were passed progressively through filters, such as fitness score, predicted activity and docking scores. The resulting hits present new scaffolds with a strong potential for D(2) antagonist. 相似文献