Clicked (AB)2C‐type miktoarm terpolymers: Synthesis,thermal and self‐assembly properties,and preparation of nanoporous materials

A well‐defined (PEO‐PS)₂‐PLA miktoarm terpolymer ( 1 ) was synthesized by stepwise click reactions of individually prepared poly(ethylene oxide) (PEO), polystyrene (PS, polymerized by atom transfer radical polymerization), and polylactide (PLA, polymerized by ring‐opening polymerization) blocks. As characterized by differential scanning calorimetry and small‐angle X‐ray scattering techniques, the terpolymer self‐assembled into a hexagonal columnar structure consisting of PLA/PEO cylindrical cores surrounded by PS chains. In contrast, the ion‐doped sample ( 1‐Li⁺ ) with lithium concentration per ethylene oxide = 0.2 exhibited a three‐phase lamellar structure, which was attributed to the microphase separation between PEO and PLA blocks and to the conformational stabilization of the longest PLA chain. The two‐phase columnar morphology before the ion doping was used to prepare a nanoporous material. PLA chains in the cylindrical core region were hydrolyzed by sodium hydroxide, producing nanopores with a pore diameter of about 14 nm. The resulted nanoporous material sank to the bottom in water, because of water‐compatible PEO chains on the walls. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2013     

Phase Transfer Catalyzed Anomeric Nucleophilic Substitutions with D-Xylopyranosyl Halides

Abstract

Anomeric pairs of per-O-acetylated-D-xylopyranosyl halides were individually treated with a wide variety of nucleophiles under mild PTC conditions. Thus, 2,3,4-tri-O-acetyl-α-D-xylopyranosyl bromide 1 provided exclusively the β-D-xylopyranosyl anomers 2-11 in good to excellent yields (65-95%). Alternatively, under the same PTC conditions, 2,3,4-tri-O-acetyl-β-D-xylopyranosyl chloride 13 afforded solely the inverted α-D-anomers 15 (82%) and 16 (67%) upon treatment with thiophenol and sodium azide, respectively. Similarly, 2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl chloride 19 provided the analogous products 20 (63%) and 21 (31%) upon treatment with thiophenol and sodium azide. In the presence of tetrabutylammonium chloride as PTC catalyst, β-xylopyranosyl chloride 13 was shown to slowly equilibrate to the α-chloride 14. Therefore, care must be taken to avoid PTC catalyst for which counter anions can cause anomerization of the starting glycosyl halides.     

Multireference calculations on low-lying states and the X~3 Π_u -~3 Π_g absorption spectra of indium dimers

Multireference configuration interaction calculations are carried out on 11 Λ-S low-lying electronic states of indium dimers. The states are investigated with spin-orbit pseudopotentials via the state-interacting method, and characterized by fitted spectroscopic constants based on computed potential energy curves. The vibrational structures of the double-potential well 0+g (I) ( 3 Σ g ) state are also analyzed. The experimentally observed absorption spectrum centred at ～ 13000cm-1 is simulated and assigned to X 3 Πu (v=0)-3Πg transition according to the present ab initio calculations on transition energies and dipole moment functions.     

Legendre函数加权的声纳宽频带恒定束宽波束特性分析*

为了处理水声信号,声纳阵列通常需要形成宽频带恒定束宽的波束。采用两种阵元加权方法分析二维圆弧形恒定束宽换能器声纳阵列:球面Legendre函数加权方法和柱面Legendre函数加权方法。分别对球面阵、柱面阵和平面阵这三种几何结构的声纳阵列进行分析,并且计算波束宽度和波束方向。结果表明,在宽频带范围内,除了柱面Legendre函数加权的球面阵之外,其余Legendre函数加权的声纳阵列均能利用简单的、不随频率变化的阵元权重和阵元延时,形成恒定束宽的波束,并且具有较小的旁瓣,此外波束方向与预设方向也较为一致。相对于其他恒定束宽波束形成方法,Legendre函数加权方法能利用较低的计算复杂度来实现良好的宽频带恒定束宽的波束特性。     

LC Coupled with TOFMS for Metabonomics Study of Mini-pigs with Atherosclerosis

In this study, serum metabolic profiles of mini-pigs with atherosclerosis (AS) were analyzed by LC–TOFMS. Partial least-squares to latent structure-discriminant analysis and orthogonal projection to latent structure-discriminant analysis were used for group differentiation and selection of potential biomarkers. The mini-pig disease models were constructed by feeding a high-fat diet and inducing coronary injury, in accordance with the mechanism of AS pathogenesis. To characterize the development of AS, serum samples were collected and analyzed at two time points (two and ten weeks). Separate distinct clustering of results from normal and model mini-pigs could be observed for both the two and ten-week samples. With the development of AS, the metabolism of the model mini-pigs was more substantially disturbed. Major metabolites contributing to the discrimination were fatty acids, lysophosphatidylcholines, and bile acids. These potential biomarkers are related with inflammation, oxidative stress, and abnormal lipid and energy metabolism.