Experimental investigation of TiO2–water nanofluid flow and heat transfer inside wavy mini-channel heat sinks

Journal of Thermal Analysis and Calorimetry - The present study comprises experimental investigation on heat transfer and hydrodynamic characteristics of TiO2 nanofluid as coolant in wavy channel...     

A Complete Foliation of Schwarzschild Spacetime by Free Falling Hypersurfaces

Free falling hypersurfaces in the Schwarzschild geometry have been studied to provide a complete foliation of spacetime. The hypersurfaces do not cross into the maximally extended spacetime and are well behaved everywhere except at the singularity r =0 the mean extrinsic curvature becomes infinity.     

The facet ideal of a simplicial complex

 To a simplicial complex, we associate a square-free monomial ideal in the polynomial ring generated by its vertex set over a field. We study algebraic properties of this ideal via combinatorial properties of the simplicial complex. By generalizing the notion of a tree from graphs to simplicial complexes, we show that ideals associated to trees satisfy sliding depth condition, and therefore have normal and Cohen-Macaulay Rees rings. We also discuss connections with the theory of Stanley-Reisner rings. Received: 7 January 2002 / Revised version: 6 May 2002     

Anti-Inflammatory Effects of the Iron Chelator,DIBI, in Experimental Acute Lung Injury

Iron plays a critical role in the immune response to inflammation and infection due to its role in the catalysis of reactive oxygen species (ROS) through the Haber-Weiss and Fenton reactions. However, ROS overproduction can be harmful and damage healthy cells. Therefore, iron chelation represents an innovative pharmacological approach to limit excess ROS formation and the related pro-inflammatory mediator cascades. The present study was designed to investigate the impact of the iron chelator, DIBI, in an experimental model of LPS-induced acute lung injury (ALI). DIBI was administered intraperitoneally in the early and later stages of lung inflammation as determined by histopathological evaluation. We found that lung tissues showed significant injury, as well as increased NF-κB p65 activation and significantly elevated levels of various inflammatory mediators (LIX, CXCL2, CCL5, CXCL10, IL-1𝛽, IL-6) 4 h post ALI induction by LPS. Mice treated with DIBI (80 mg/kg) in the early stages (0 to 2 h) after LPS administration demonstrated a significant reduction of the histopathological damage score, reduced levels of NF-κB p65 activation, and reduced levels of inflammatory mediators. Intravital microscopy of the pulmonary microcirculation also showed a reduced number of adhering leukocytes and improved capillary perfusion with DIBI administration. Our findings support the conclusion that the iron chelator, DIBI, has beneficial anti-inflammatory effects in experimental ALI.     

A New MBH Adduct as an Efficient Ligand in the Synthesis of Metallodrugs: Characterization,Geometrical Optimization,XRD, Biological Activities,and Molecular Docking Studies

This article reports the synthesis, characterization, geometrical optimization, and biological studies of new MBH-based organometallic compounds of medicinal significance. The ligand (MNHA) was prepared via the Morita–Baylis–Hillman (MBH) synthetic route, from aromatic aldehyde containing multiple functional groups. Metal complexes were prepared in an alkaline medium and under other suitable reaction conditions. Spectral and elemental analyses were used to identify the structural and molecular formulas of each compound. Optimized geometry was determined through density functional theory (DFT) B3LYP and 6-311++ G (d,p) basis set for the MBH adduct, whereas structures of novel complexes were optimized with the semi-empirical PM6 method. Powder XRD analysis furnished the crystal class of complexes, with Co³⁺, Cr³⁺, and Mn²⁺ being cubic, while Ni²⁺ was hexagonal, and Cu²⁺ was orthorhombic. Moreover, the ligand, along with Ni²⁺ and Co³⁺ complexes, showed profound antibacterial action against S. aureus, E. coli, B. pumilis, and S. typhi. Additionally, all of the complexes were shown to persist in the positive antioxidant potential of the ligand. Contrarily, not a single metal complex conserved the antifungal potentials of the ligand.