Click chemistry inspired synthesis of ferrocene amino acids and other derivatives

This work reports the synthesis of a wide range of ferrocenyl-amino acids and other derivatives in excellent yield. Diverse amino acid containing azides were synthesized and ligated to ferrocene employing click reaction to access ferrocenyl amino acids. Chiral alcohols, esters, diols, amines containing azido group were tagged to ferrocene via click reaction to generate ferrocene derived chiral derivatives. A novel strategy for direct incorporation of ferrocene into a peptide and a new route to 1, 1′disubstituted ferrocene amino acid derivative are reported.     

Density, Excess Volume, and Viscosity of Vinyl Acetate or?Benzyl Acetate with (o-, m-, p-)Xylenes and?Ethylbenzene at T=(303.15 and 313.15) K

Viscosity η, and density ρ, of binary liquid mixtures of vinyl acetate or benzyl acetate with o-xylene, m-xylene, p-xylene and ethyl benzene have been determined at (303.15 and 313.15) K for the entire composition range. From the experimental values excess molar volume and deviations in viscosity have been calculated. These excess quantities were fitted to the Redlich-Kister polynomial equation. The viscosity data have been correlated using the Grunberg-Nissan, Tamura and Kurata, Auslander, and Jouyban-Acree models.     

The Chemical Composition and Antimitotic,Antioxidant, Antibacterial and Cytotoxic Properties of the Defensive Gland Extract of the Beetle,Luprops tristis Fabricius

The unpredictable invasion of the Mupli beetle, Luprops tristis Fabricius (Coleoptera: Tenebrionidae), makes areas uninhabitable to humans. These beetles produce a strong-smelling, irritating secretion as a defence mechanism, which causes blisters on contact with human skin. In the current study, gas chromatography high-resolution mass spectrometry (GC-HRMS) analysis of the defensive gland extract of the Mupli beetle revealed the presence of compounds such as 2,3,dimethyl-1,4-benzoquinone, 1,3-dihydroxy-2-methylbenzene, 2,5-dimethyl hydroquinone, tetracosane, oleic acid, hexacosane, pentacosane, 7-hexadecenal and tert-hexadecanethiol. The defensive gland extracts showed considerable antibacterial activity on Gram-negative and Gram-positive bacteria in an agar diffusion assay. The chromosomal aberration analysis using root tips of Allium cepa L. exposed to the defensive secretion showed chromosomal aberrations such as disturbed metaphase, sticky chromosomes and chromosomal breakage. The antioxidant activity of the extract was determined using a radical scavenging (DPPH) assay. A cytotoxic assay of the defensive gland extract against Dalton’s lymphoma ascites (DLA) cell line showed anticancer properties. In the present study, the defensive gland extract of the Mupli beetle, L. tristis, which is generally perceived as a nuisance insect to humans, was found to have beneficial biological activities.