A rapid,highly efficient,and general protocol for the synthesis of functionalized triarylmethanes: a straightforward access for the synthesis of (−)-tatarinoid C

A rapid, efficient, and convenient synthesis of functionalized triarylmethane is described by the Friedel–Crafts alkylation of methoxybenzenes with a variety of aldehydes in the presence of BF₃·OEt₂. The generality of the method is demonstrated by screening a variety of di- or tri-substituted arenes as well as substituted aromatic, heteroaromatic, and aliphatic aldehydes. (−)-Tatarinoid C is synthesized in a single step following the same protocol.     

Design,Synthesis, and Evaluation of Isoxazole-Thiadiazole Linked Carbazole Hybrids as Anticancer Agents

Russian Journal of General Chemistry - A series of isoxazole-thiadiazole linked carbazole derivatives 12a–12j are synthesized and their chemical structures confirmed by 1H and 13C NMR and...     

Multimetallic Oxynitrides Nanoparticles for a New Generation of Photocatalysts

A versatile synthetic strategy for the preparation of multimetallic oxynitrides has been designed and here exemplarily discussed considering the preparation of nanoscaled zinc–gallium oxynitrides and zinc–gallium–indium oxynitrides, two important photocatalysts of new generation, which proved to be active in key energy related processes from pollutant decomposition to overall water splitting. The synthesis presented here allows the preparation of small nanoparticles (less than 20 nm in average diameter), well-defined in size and shape, yet highly crystalline and with the highest surface area reported so far (up to 80 m² g⁻¹). X-ray diffraction studies show that the final material is not a mixture of single oxides but a distinctive compound. The photocatalytic properties of the oxynitrides have been tested towards the decomposition of an organic dye (as a model reaction for the decomposition of air pollutants), showing better photocatalytic performances than the corresponding pure phases (reaction constant 0.22 h⁻¹), whereas almost no reaction was observed in absence of catalyst or in the dark. The photocatalysts have been also tested for H₂ evolution (semi-reaction of the water splitting process) with results comparable to the best literature values but leaving room for further improvement.     

Ln0.5A0.5MnO3 (Ln=Lanthanide,A= Ca,Sr) Perovskites Exhibiting Remarkable Performance in the Thermochemical Generation of CO and H2 from CO2 and H2O

Perovskite oxides of the Ln_0.5A_0.5MnO₃ (Ln=lanthanide, A=Sr, Ca) family have been investigated for the thermochemical splitting of H₂O and CO₂ to produce H₂ and CO respectively. The amounts of O₂ and CO produced strongly depend on the size of the rare earth ions and alkaline earth ions. The manganite with the smallest rare earth possessing the highest distortion and size disorder as well as the smallest tolerance factor, gives out the maximum amount of O₂, and, hence, the maximum amount of CO. Thus, the best results are found with Y_0.5Sr_0.5MnO₃, which possesses the highest distortion and size disorder. Y_0.5Sr_0.5MnO₃ shows remarkable fuel production activity even at the reduction and oxidation temperatures as low as 1200 °C and 900 °C, respectively.     

Synthesis of phenanthroimidazole-based four coordinate organoboron compounds

The synthesis of N,C-coordinated organoboron compounds (B1-B4) based on phenanthroimidazole described. All the compounds were characterized by various spectroscopic techniques. Single crystal X-ray diffraction analysis of the compounds B1 and B3 revealed that the vicinity around the boron atom adopts tetrahedral geometry. Except compound B4, other organoboron compounds (B1-B3) does not show solvatochromism. All our newly synthesized organoboron compounds exhibited moderate to good solution state quantum yields (0.07–0.88) and moderate solid state quantum yields.     

Ionic liquid‐based dispersive liquid–liquid microextraction followed by RP‐HPLC determination of saquinavir in rat serum: application to pharmacokinetics

An ionic liquid‐based dispersive liquid–liquid microextraction followed by RP‐HPLC determination of the most commonly prescribed protease inhibitor, saquinavir, in rat plasma was developed and validated. The effects of different ionic liquids, dispersive solvents, extractant/disperser ratio and salt concentration on sample recovery and enrichment were studied. Among the ionic liquids investigated, 1‐butyl‐3‐methylimidazolium hexafluorophosphate was found to be most effective for extraction of saquinavir from rat serum. The recovery was found to be 95% at an extractant/disperser ratio of 0.43 using 1‐butyl‐3‐methylimidazolium hexafluorophosphate and methanol as extraction and dispersive solvents. The recovery was further enhanced to 99.5% by addition of 5.0% NaCl. A threefold enhancement in detection and quantification limits was achieved, at 0.01 and 0.03 µg/mL, compared with the conventional protein precipitation method. A linear relationship was observed in the range of 0.035–10.0 µg/mL with a correlation coefficient (r²) of 0.9996. The method was validated and applied to study pharmacokinetics of saquinavir in rat serum. Copyright © 2014 John Wiley & Sons, Ltd.     

Microscopic multi-point temperature sensing based on microfiber double-knot resonators

A novel fiber-optic sensor structure fabricated by cascading two optical microfiber knot resonators (MKRs) is proposed and demonstrated in this paper. A theoretical model for describing the principle of the sensing structure is given and its temperature responses are characterized experimentally. Experimental results show that high-precision and simultaneous multi-point temperature sensing in micro-scale can be achieved. Such a sensing structure also has the potential for achieving dual-parameter measurement to eliminate the cross-talk between two parameters in micro-scale.