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101.
This report focuses on the synthesis of gold‐nickel bimetallic nanostructures. In the presence of amine as the capping agent, thermal decomposition of organometallic precursors CH3AuPPh3 and Ni(PPh3)4 in o‐xylene offered AuNi nanorods. Several preparative parameters possible influencing the morphology of the structure were carefully studied by varying the reaction conditions with respect to the standard procedure. The morphology and composition of the AuNi nanorods were principally characterized by transmission electron microscopy, energy dispersive spectroscopy, and powder X‐ray diffraction. The distribution of the Au as well as Ni atoms was examined by EDS mapping analysis. The mechanism of the formation of the AuNi bimetallic nanorods is proposed on the base of observation of the morphologies of nanostructures at various reaction time intervals. 相似文献
102.
Shivkanya Fuloria Muhamad Azrul Amir Yusri Mahendran Sekar Siew Hua Gan Nur Najihah Izzati Mat Rani Pei Teng Lum Subban Ravi Vetriselvan Subramaniyan Abul Kalam Azad Srikanth Jeyabalan Yuan Seng Wu Dhanalekshmi Unnikrishnan Meenakshi Kathiresan V. Sathasivam Neeraj Kumar Fuloria 《Molecules (Basel, Switzerland)》2022,27(1)
Genistein is a naturally occurring polyphenolic molecule in the isoflavones group which is well known for its neuroprotection. In this review, we summarize the efficacy of genistein in attenuating the effects of memory impairment (MI) in animals. Scopus, PubMed, and Web of Science databases were used to find the relevant articles and discuss the effects of genistein in the brain, including its pharmacokinetics, bioavailability, behavioral effects, and some of the potential mechanisms of action on memory in several animal models. The results of the preclinical studies highly suggested that genistein is highly effective in enhancing the cognitive performance of the MI animal models, specifically in the memory domain, including spatial, recognition, retention, and reference memories, through its ability to reduce oxidative stress and attenuate neuroinflammation. This review also highlighted challenges and opportunities to improve the drug delivery of genistein for treating MI. Along with that, the possible structural modifications and derivatives of genistein to improve its physicochemical and drug-likeness properties are also discussed. The outcomes of the review proved that genistein can enhance the cognitive performance and ameliorate MI in different preclinical studies, thus indicating its potential as a natural lead for the design and development of a novel neuroprotective drug. 相似文献
103.
Nur Hanisah Mustafa Mahendran Sekar Shivkanya Fuloria M. Yasmin Begum Siew Hua Gan Nur Najihah Izzati Mat Rani Subban Ravi Kumarappan Chidambaram Vetriselvan Subramaniyan Kathiresan V. Sathasivam Srikanth Jeyabalan Subasini Uthirapathy Sivasankaran Ponnusankar Pei Teng Lum Vijay Bhalla Neeraj Kumar Fuloria 《Molecules (Basel, Switzerland)》2022,27(6)
Sarsasapogenin is a natural steroidal sapogenin molecule obtained mainly from Anemarrhena asphodeloides Bunge. Among the various phytosteroids present, sarsasapogenin has emerged as a promising molecule due to the fact of its diverse pharmacological activities. In this review, the chemistry, biosynthesis and pharmacological potentials of sarsasapogenin are summarised. Between 1996 and the present, the relevant literature regarding sarsasapogenin was obtained from scientific databases including PubMed, ScienceDirect, Scopus, and Google Scholar. Overall, sarsasapogenin is a potent molecule with anti-inflammatory, anticancer, antidiabetic, anti-osteoclastogenic and neuroprotective activities. It is also a potential molecule in the treatment for precocious puberty. This review also discusses the metabolism, pharmacokinetics and possible structural modifications as well as obstacles and opportunities for sarsasapogenin to become a drug molecule in the near future. More comprehensive preclinical studies, clinical trials, drug delivery, formulations of effective doses in pharmacokinetics studies, evaluation of adverse effects and potential synergistic effects with other drugs need to be thoroughly investigated to make sarsasapogenin a potential molecule for future drug development. 相似文献
104.
Geethanjali Thayumanavan Srikanth Jeyabalan Shivkanya Fuloria Mahendran Sekar Monica Ravi Logesh Kumar Selvaraj Logeshwari Bala Kumarappan Chidambaram Siew Hua Gan Nur Najihah Izzati Mat Rani M. Yasmin Begum Vetriselvan Subramaniyan Kathiresan V. Sathasivam Dhanalekshmi U. Meenakshi Neeraj Kumar Fuloria 《Molecules (Basel, Switzerland)》2022,27(8)
Bisphenol A (BPA), a well-known xenoestrogen, is commonly utilised in the production of polycarbonate plastics. Based on the existing evidence, BPA is known to induce neurotoxicity and behavioural issues. Flavonoids such as silibinin and naringenin have been shown to have biological activity against a variety of illnesses. The current research evaluates the neuropharmacological effects of silibinin and naringenin in a zebrafish model against neurotoxicity and oxidative stress caused by Bisphenol A. In this study, a novel tank diving test (NTDT) and light–dark preference test (LDPT) were used in neurobehavioural investigations. The experimental protocol was planned to last 21 days. The neuroprotective effects of silibinin (10 μM) and naringenin (10 μM) in zebrafish (Danio rerio) induced by BPA (17.52 μM) were investigated. In the brine shrimp lethality assay, the 50% fatal concentrations (LC50) were 34.10 μg/mL (silibinin) and 91.33 μg/mL (naringenin) compared to the standard potassium dichromate (13.15 μg/mL). The acute toxicity investigation found no mortality or visible abnormalities in the silibinin- and naringenin-treated groups (LC50 > 100 mg/L). The altered scototaxis behaviour in LDPT caused by BPA was reversed by co-supplementation with silibinin and naringenin, as shown by decreases in the number of transitions to the light zone and the duration spent in the light zone. Our findings point to BPA’s neurotoxic potential in causing altered scototaxis and bottom-dwelling behaviour in zebrafish, as well as the usage of silibinin and naringenin as potential neuroprotectants. 相似文献
105.
Jyoti Mehta Kumar Utkarsh Shivkanya Fuloria Tejpal Singh Mahendran Sekar Deeksha Salaria Rajan Rolta M. Yasmin Begum Siew Hua Gan Nur Najihah Izzati Mat Rani Kumarappan Chidambaram Vetriselvan Subramaniyan Kathiresan V. Sathasivam Pei Teng Lum Subasini Uthirapathy Olatomide A. Fadare Oladoja Awofisayo Neeraj Kumar Fuloria 《Molecules (Basel, Switzerland)》2022,27(15)
Urinary tract infections (UTIs) are becoming more common, requiring extensive protection from antimicrobials. The global expansion of multi-drug resistance uropathogens in the past decade emphasizes the necessity of newer antibiotic treatments and prevention strategies for UTIs. Medicinal plants have wide therapeutic applications in both the prevention and management of many ailments. Bacopa monnieri is a medicinal plant that is found in the warmer and wetlands regions of the world. It has been used in Ayurvedic systems for centuries. The present study aimed to investigate the antibacterial potential of the extract of B. monnieri leaves and its bioactive molecules against UTIs that are caused by Klebsiella pneumoniae and Proteus mirabilis. This in vitro experimental study was conducted by an agar well diffusion method to evaluate the antimicrobial effect of 80% methanol, 96% ethanol, and aqueous extracts of B. monnieri leaves on uropathogens. Then, further screening of their phytochemicals was carried out using standard methods. To validate the bioactive molecules and the microbe interactions, AutoDock Vina software was used for molecular docking with the Klebsiella pneumoniae fosfomycin resistance protein (5WEW) and the Zn-dependent receptor-binding domain of Proteus mirabilis MR/P fimbrial adhesin MrpH (6Y4F). Toxicity prediction and drug likeness were predicted using ProTox-II and Molinspiration, respectively. A molecular dynamics (MD) simulation was carried out to study the protein ligand complexes. The methanolic leaves extract of B. monnieri revealed a 22.3 mm ± 0.6 mm to 25.0 mm ± 0.5 mm inhibition zone, while ethanolic extract seemed to produce 19.3 mm ± 0.8 mm to 23.0 mm ± 0.4 mm inhibition zones against K. pneumoniae with the use of increasing concentrations. In the case of P. mirabilis activity, the methanolic extracts showed a 21.0 mm ± 0.8 mm to 24.0 mm ± 0.6 mm zone of inhibition and the ethanol extract produced a 17.0 mm ± 0.9 mm to 23.0 mm ± 0.7 mm inhibition zone with increasing concentrations. Carbohydrates, flavonoids, saponin, phenolic, and terpenoid were common phytoconstituents identified in B. monnieri extracts. Oroxindin showed the best interactions with the binding energies with 5WEW and 6Y4F, −7.5 kcal/mol and −7.4 kcal/mol, respectively. Oroxindin, a bioactive molecule, followed Lipinski’s rule of five and exhibited stability in the MD simulation. The overall results suggest that Oroxindin from B. monnieri can be a potent inhibitor for the effective killing of K. pneumoniae and P. mirabilis. Additionally, its safety has been established, indicating its potential for future drug discovery and development in the treatment for UTIs. 相似文献
106.
Selvam Athavan Alias Anand Kiran George Nisha Susan Thomas 《Phosphorus, sulfur, and silicon and the related elements》2020,195(10):821-829
AbstractTwo series of thiazinone and thiosemicarbazone derivatives (1-12) were synthesized using 2,4-diaryl-3-azabicyclo[3.3.1]nonan-9-ones (ABNs) and 3–alkyl–2,6–diarylpiperidin–4–ones as the starting materials. The structures of newly synthesized compounds were established on the basis of FT–IR, NMR spectroscopy and mass spectrometry. From the spectroscopic data, we identified that the cyclization reaction of thioamide with dialkyl acetylenedicarboxylate selectively gives six membered methyl 2-(2-(2,4-disubstituted-3-azabicyclo[3.3.1]nonan-9-ylidene)hydrazinyl)-4-oxo-4H-1,3-thiazine-6-carboxylates (1-6). In order to investigate the antitumor activities of the synthesized compounds, in vitro cytotoxicity studies were carried out using human prostate cancer cell lines. Tested compounds showed good/moderate activities against cancer cell lines and further investigation carried out by live/dead assay. 相似文献
107.
108.
Karuturi Rajesh Vangaru Suresh Jondoss Jon Paul Selvam Dokuburra Chanti Babu Yenamandra Venkateswarlu 《Helvetica chimica acta》2010,93(1):147-152
A simple and highly efficient stereoselective total synthesis of (11β)‐11‐methoxycurvularin ( 5 ), a polyketide natural product, was achieved. The synthesis commenced with a Cu‐mediated regioselective opening of (2S)‐2‐methyloxirane ( 6 ) and comprised a Keck asymmetric allylation and intramolecular Friedel–Crafts acylation as key steps (Scheme 2). 相似文献
109.
D. S. Krivoruchenko A. V. Kucherov N. S. Telegina D. A. Bokarev P. Selvam A. Yu. Stakheev 《Russian Chemical Bulletin》2014,63(2):389-395
The catalytic properties of the Mn-Fe-Beta system with Mn contents in the range 0.1–16 wt.% were studied in the selective catalytic reduction (SCR) of NO x with ammonia. The catalyst structure was investigated using IR spectra of adsorbed NO, temperature-programmed reduction with hydrogen (H2-TPR), X-ray diffraction analysis, and ESR. The use of manganese as a promoter substantially increases the activity of iron-containing catalysts in the SCR of NO x with ammonia. At low contents (<2 wt.%), Mn exists in the cation form and the catalytic activity of the Mn-Fe-Beta system does not increase. At a higher content of Mn, clusters MnO x begin to form, which are highly active in the oxidation of NO to NO2 and the low-temperature catalytic activity of the Mn-Fe-Beta system increases. The observed increase in the low-temperature catalytic activity in the process of SCR of NO x with ammonia is related to a change in the reaction route. The MnO x clusters favor the oxidation of NO and the iron cations facilitate the reaction of “fast” SCR. 相似文献