Delay‐dependent robust reliable control for uncertain switched neutral systems

This article investigates the robust reliable control problem for a class of uncertain switched neutral systems with mixed interval time‐varying delays. The system under study involves state time‐delay, parameter uncertainties and possible actuator failures. In particular, the parameter uncertainties is assumed to satisfy linear fractional transformation formulation and the involved state delay are assumed to be randomly time varying which is modeled by introducing Bernoulli distributed sequences. The main objective of this article is to obtain robust reliable feedback controller design to achieve the exponential stability of the closed‐loop system in the presence of for all admissible parameter uncertainties. The proposed results not only applicable for the normal operating case of the system, but also in the presence of certain actuator failures. By constructing an appropriate Lyapunov–Krasovskii functional, a new set of criteria is derived for ensuring the robust exponential stability of the closed‐loop switched neutral system. More precisely, zero inequality approach, Wirtinger's based inequality, convex combination technique and average dwell time approach are used to simplify the derivation in the main results. Finally, numerical examples with simulation result are given to illustrate the effectiveness and applicability of the proposed design approach. © 2015 Wiley Periodicals, Inc. Complexity 21: 224–237, 2016     

The effect of double-chain surfactants on armored bubbles: a surfactant-controlled route to colloidosomes

We find that the gas phases of air bubbles covered with anionic or cationic polystyrene latex particles dissolve on exposure to cationic and catanionic surfactants. The particles on the bubble interface are released as singlets or aggregates when the surfactant has a single hydrophobic chain, while porous colloidal capsules (colloidosomes) with the same aqueous phase inside as out are obtained when the surfactant has two hydrophobic chains. The formation of colloidosomes from the particle-covered bubbles does not appear to depend significantly on the charge of the particles, which makes it unlikely that bilayers of surfactant are stabilizing the colloidosome. While the exact mechanism of formation remains an open question, our method is a simple one-step process for obtaining colloidosomes from particle-covered bubbles.     

Drag law for monodisperse gas–solid systems using particle-resolved direct numerical simulation of flow past fixed assemblies of spheres

Gas–solid momentum transfer is a fundamental problem that is characterized by the dependence of normalized average fluid–particle force F on solid volume fraction ? and the Reynolds number based on the mean slip velocity Re_m. In this work we report particle-resolved direct numerical simulation (DNS) results of interphase momentum transfer in flow past fixed random assemblies of monodisperse spheres with finite fluid inertia using a continuum Navier–Stokes solver. This solver is based on a new formulation we refer to as the Particle-resolved Uncontaminated-fluid Reconcilable Immersed Boundary Method (PUReIBM). The principal advantage of this formulation is that the fluid stress at the particle surface is calculated directly from the flow solution (velocity and pressure fields), which when integrated over the surfaces of all particles yields the average fluid–particle force. We demonstrate that PUReIBM is a consistent numerical method to study gas–solid flow because it results in a force density on particle surfaces that is reconcilable with the averaged two-fluid theory. The numerical convergence and accuracy of PUReIBM are established through a comprehensive suite of validation tests. The normalized average fluid–particle force F is obtained as a function of solid volume fraction ? (0.1 ? ? ? 0.5) and mean flow Reynolds number Re_m (0.01 ? Re_m ? 300) for random assemblies of monodisperse spheres. These results extend previously reported results of  and  to a wider range of ?, Re_m, and are more accurate than those reported by Beetstra et al. (2007). Differences between the drag values obtained from PUReIBM and the drag correlation of Beetstra et al. (2007) are as high as 30% for Re_m in the range 100–300. We take advantage of PUReIBM’s ability to directly calculate the relative contributions of pressure and viscous stress to the total fluid–particle force, which is useful in developing drag correlations. Using a scaling argument, Hill et al. (2001b) proposed that the viscous contribution is independent of Re_m but the pressure contribution is linear in Re_m (for Re_m > 50). However, from PUReIBM simulations we find that the viscous contribution is not independent of the mean flow Reynolds number, although the pressure contribution does indeed vary linearly with Re_m in accord with the analysis of Hill et al. (2001b). An improved correlation for F in terms of ? and Re_m is proposed that corrects the existing correlations in Re_m range 100–300. Since this drag correlation has been inferred from simulations of fixed particle assemblies, it does not include the effect of mobility of the particles. However, the fixed-bed simulation approach is a good approximation for high Stokes number particles, which are encountered in most gas–solid flows. This improved drag correlation can be used in CFD simulations of fluidized beds that solve the average two-fluid equations where the accuracy of the drag law affects the prediction of overall flow behavior.     

Streaming current and wall dissolution over 48 h in silica nanochannels

We present theoretical and experimental studies of the streaming current induced by a pressure-driven flow in long, straight, electrolyte-filled nanochannels. The theoretical work builds on our recent one-dimensional model of electro-osmotic and capillary flow, which self-consistently treats both the ion concentration profiles, via the nonlinear Poisson-Boltzmann equation, and the chemical reactions in the bulk electrolyte and at the solid-liquid interface. We extend this model to two dimensions and validate it against experimental data for electro-osmosis and pressure-driven flows, using eight 1-μm-wide nanochannels of heights varying from 40 nm to 2000 nm. We furthermore vary the electrolyte composition using KCl and borate salts, and the wall coating using 3-cyanopropyldimethylchlorosilane. We find good agreement between prediction and experiment using literature values for all parameters of the model, i.e., chemical reaction constants and Stern-layer capacitances. Finally, by combining model predictions with measurements over 48 h of the streaming currents, we develop a method to estimate the dissolution rate of the silica walls, typically around 0.01 mg/m(2)/h, equal to 45 pm/h or 40 nm/yr, under controlled experimental conditions.     

Method to determine the effective ζ potential in a microchannel with an embedded gate electrode

We present a theoretical model to determine the effective zeta potential ζ(eff) in microfluidic channels where an embedded, insulated gate electrode allows for external tuning of a portion of the channel surface charge. In addition, we derive a method to determine ζ(eff) in such channels, for any value of salt concentration, using the solution displacement technique. To do so, we simulate typical current-monitoring measurements using our model, and highlight the experimental parameters that lead to inaccurate results using this procedure with an heterogenous channel. Our method corrects for such inaccuracies by using our model with experimental data to find the correct value of ζ(eff) . Finally, we perform experiments to demonstrate our method and the use of our model with a silica-PMDS microchannel system with an embedded Ti-Au-Ti gate electrode that covers 50% of the bottom surface of the channel. We show that our theory captures the salient features of our experiments, thereby offering a useful tool to predict effective zeta potential in channels with a nonuniform zeta potential.     

Evaluation of the effects of Mitragyna speciosa alkaloid extract on cytochrome P450 enzymes using a high throughput assay

The extract from Mitragyna speciosa has been widely used as an opium substitute, mainly due to its morphine-like pharmacological effects. This study investigated the effects of M. speciosa alkaloid extract (MSE) on human recombinant cytochrome P450 (CYP) enzyme activities using a modified Crespi method. As compared with the liquid chromatography-mass spectrometry method, this method has shown to be a fast and cost-effective way to perform CYP inhibition studies. The results indicated that MSE has the most potent inhibitory effect on CYP3A4 and CYP2D6, with apparent half-maximal inhibitory concentration (IC(50)) values of 0.78 μg/mL and 0.636 μg/mL, respectively. In addition, moderate inhibition was observed for CYP1A2, with an IC(50) of 39 μg/mL, and weak inhibition was detected for CYP2C19. The IC(50) of CYP2C19 could not be determined, however, because inhibition was <50%. Competitive inhibition was found for the MSE-treated CYP2D6 inhibition assay, whereas non-competitive inhibition was shown in inhibition assays using CYP3A4, CYP1A2 and CYP2C19. Quinidine (CYP2D6), ketoconazole (CYP3A4), tranylcypromine (CYP2C19) and furafylline (CYP1A2) were ACCESSused as positive controls throughout the experiments. This study shows that MSE may contribute to an herb-drug interaction if administered concomitantly with drugs that are substrates for CYP3A4, CYP2D6 and CYP1A2.     

An isomer-specific high-energy collision-induced dissociation MS/MS database for forensic applications: a proof-of-concept on chemical warfare agent markers

Spectra database search has become the most popular technique for the identification of unknown chemicals, minimizing the need for authentic reference chemicals. In the present study, an isomer‐specific high‐energy collision‐induced dissociation (CID) MS/MS spectra database of 12 isomeric O‐hexyl methylphosphonic acids (degradation markers of nerve agents) was created. Phosphonate anions were produced by the electrospray ionization of phosphonic acids or negative‐ion chemical ionization of their fluorinated derivatives and were analysed in a hybrid magnetic‐sector–time‐of‐flight tandem mass spectrometer. A centre‐of‐mass energy (E_com) of 65 eV led to an optimal sequential carbon–carbon bond breakage, which was interpreted in terms of charge remote fragmentation. The proposed mechanism is discussed in comparison with the routinely used low‐energy CID MS/MS. Even‐mass (odd‐electron) charge remote fragmentation ion series were diagnostic of the O‐alkyl chain structure and can be used to interpret unknown spectra. Together with the odd‐mass ion series, they formed highly reproducible, isomer‐specific spectra that gave significantly higher database matches and probability factors (by 1.5 times) than did the EI MS spectra of the trimethylsilyl derivatives of the same isomers. In addition, ionization by negative‐ion chemical ionization and electrospray ionization resulted in similar spectra, which further highlights the general potential of the high‐energy CID MS/MS technique. Copyright © 2011 John Wiley & Sons, Ltd.     

Synthesis and structural characterization of high spin M/Cu (M = Mn, Fe) heterobimetallic and Fe/Cu2 trimetallic phosphinoamides

The heterobimetallic complexes [Mn((i)PrNPPh(2))(3)Cu((i)PrNHPPh(2))] (1) and [Fe((i)PrNPPh(2))(3)Cu((i)PrNHPPh(2))] (2) have been synthesized by the one pot reaction of LiN(i)PrPPh(2), MCl(2) (M = Mn, Fe), and CuI in high yield. Addition of excess CuI into 2 or directly to the reaction mixture led to the formation of a heterotrimetallic [Fe((i)PrNPPh(2))(3)Cu(2)((i)PrNPPh(2))] (3) in good yield. Complexes 1-3 have been characterized by means of elemental analysis, paramagnetic (1)H NMR, UV-vis spectroscopy, cyclic voltammetry, and single crystal X-ray analysis. In all three complexes, Mn or Fe are in the +2 oxidation state and have a high spin electron configuration, as evidenced by solution Evans' method. In addition, the oxidation state of Fe in complex 3 is confirmed by zero-field (57)Fe M?ssbauer spectroscopy. X-ray crystallography reveals that the three coordinate Mn/Fe centers in the zwitterionic complexes 1-3 adopt an unusual trigonal planar geometry.     

AlMe(3)-promoted formation of amides from acids and amines

In the presence of AlMe(3), amines can be directly coupled with acids through dimethylaluminum amide intermediates to form the corresponding amides. A wide range of amines and acids including less nucleophilic amines, bulky amines, unprotected secondary amino acids, and acids with poor solubility were coupled smoothly to give the desired products in 55-98% yields.     

Nanomechanical properties of single amyloid fibrils

Amyloid fibrils are traditionally associated with neurodegenerative diseases like Alzheimer's disease, Parkinson's disease or Creutzfeldt-Jakob disease. However, the ability to form amyloid fibrils appears to be a more generic property of proteins. While disease-related, or pathological, amyloid fibrils are relevant for understanding the pathology and course of the disease, functional amyloids are involved, for example, in the exceptionally strong adhesive properties of natural adhesives. Amyloid fibrils are thus becoming increasingly interesting as versatile nanobiomaterials for applications in biotechnology. In the last decade a number of studies have reported on the intriguing mechanical characteristics of amyloid fibrils. In most of these studies atomic force microscopy (AFM) and atomic force spectroscopy play a central role. AFM techniques make it possible to probe, at nanometer length scales, and with exquisite control over the applied forces, biological samples in different environmental conditions. In this review we describe the different AFM techniques used for probing mechanical properties of single amyloid fibrils on the nanoscale. An overview is given of the existing mechanical studies on amyloid. We discuss the difficulties encountered with respect to the small fibril sizes and polymorphic behavior of amyloid fibrils. In particular, the different conformational packing of monomers within the fibrils leads to a heterogeneity in mechanical properties. We conclude with a brief outlook on how our knowledge of these mechanical properties of the amyloid fibrils can be exploited in the construction of nanomaterials from amyloid fibrils.