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101.
V. B. Kovalska M. Yu Losytskyy O. I. Tolmachev Yu L. Slominskii G. M. J. Segers-Nolten V. Subramaniam S. M. Yarmoluk 《Journal of fluorescence》2012,22(6):1441-1448
The pathogenesis of Parkinson’s disease that is the second most common neurodegenerative disease is associated with formation of different aggregates of α-synuclein (ASN), namely oligomers and amyloid fibrils. Current research is aimed on the design of fluorescent dyes for the detection of oligomeric aggregates, which are considered to be toxic and morbific spices. Fluorescent properties of series of benzothiazole trimethine and pentamethine cyanines were characterized in free state and in presence of monomeric, oligomeric and fibrilar ASN. The dyes with wide aromatic systems and bulky phenyl and alkyl substituents that are potentially able to interact with hydrophobic regions of oligomeric aggregates were selected for the studies. For majority of studied dyes noticeable changes in fluorescence characteristics were shown in the presence of fibrillar or oligomeric ASN, while the dyes slightly responded on the presence of monomeric protein. For pentamethine cyanine SL-631 and trimethine cyanine SH-299 certain specificity to oligomeric aggregates over fibrils was observed. Using these dyes at 10?6 M concentration permits the detection of oligomeric ASN in the concentrations range of at least 0.2–2 microM. Pentamethine cyanine SL-631 is proposed as dye for fluorescent detection of oligomeric aggregates of ASN, while trimethine cyanine SH-299 is shown to be a sensitive probe both on oligomeric and fibrillar ASN. It is proposed that wide aromatic system of SL-631 pentamethine dye molecule could better fix on the less dense and structured oligomeric formation, while less bulky and more “crescent-shape” molecule of trimethine dye SH-299 could easier enter into the groove of beta-pleated structure. 相似文献
102.
Thangaraj Arasakumar Sadasivam Mathusalini Athar Ata Ramasamy Shankar Subashini Gopalan Krishnasamy Lakshmi Pandiyarajan Sakthivel Palathurai Subramaniam Mohan 《Molecular diversity》2017,21(1):37-52
A series of 4-quinolone-3-carboxylic acid-containing spirooxindole-pyrrolidine derivatives was synthesized via multicomponent 1,3-dipolar cycloaddition reactions of azomethine ylides with new (E)-4-oxo-6-(3-phenyl-acryloyl)-1,4-dihydroquinoline-3-carboxylic acids in good yields with high regioselectivity. The cycloadducts were characterized by analytical and spectral data including \(^{1}\hbox {H}\), \(^{13}\hbox {C}\), 2D NMR and mass spectroscopy. The structure of one of the compounds (8a) was investigated theoretically by computational techniques. DFT studies support the proposed mechanism for this cycloaddition reaction. Furthermore, antibacterial activities of the new compounds were evaluated against Gram-positive and Gram-negative bacterial strains. Compounds 8f, 8m and 8p showed potent inhibition activities against selected bacteria. The in vitro cytotoxicity of spirooxindole derivatives (8a–r) was evaluated against MCF-7 breast cancer cell line. Among the various compounds tested, compound 8f \((\hbox {IC}_{50} = 18.35~\upmu \hbox {M})\) showed significant cytotoxic activity compared to the standard drug doxorubicin \((\hbox {IC}_{50 }= 15.00~\upmu \hbox {M})\). 相似文献
103.
Experiments indicate that particle clusters that form in fluidized–bed risers can enhance gas-phase velocity fluctuations. Direct numerical simulations (DNS) of turbulent flow past uniform and clustered configurations of fixed particle assemblies at the same solid volume fraction are performed to gain insight into particle clustering effects on gas-phase turbulence, and to guide model development. The DNS approach is based on a discrete-time, direct-forcing immersed boundary method (IBM) that imposes no-slip and no-penetration boundary conditions on each particle’s surface. Results are reported for mean flow Reynolds number Re p ?=?50 and the ratio of the particle diameter d p to Kolmogorov scale is 5.5. The DNS confirm experimental observations that the clustered configurations enhance the level of fluid-phase turbulent kinetic energy (TKE) more than the uniform configurations, and this increase is found to arise from a lower dissipation rate in the clustered particle configuration. The simulations also reveal that the particle-fluid interaction results in significantly anisotropic fluid-phase turbulence, the source of which is traced to the anisotropic nature of the interphase TKE transfer and dissipation tensors. This study indicates that when particles are larger than the Kolmogorov scale (d p ?>?η), modeling the fluid-phase TKE alone may not be adequate to capture the underlying physics in multiphase turbulence because the Reynolds stress is anisotropic. It also shows that multiphase turbulence models should consider the effect of particle clustering in the dissipation model. 相似文献
104.
Bijendra Singh V.V. Subramaniam S.R. Daultabad Ashim Chakraborty 《Optics Communications》2008,281(17):4415-4423
It is established here that kinetically enhanced copper vapor lasers (KE-CVLs) based on large-bore discharge tubes can provide high (>1.4%) efficiency at ∼9-10 kHz rep-rate with very low (<2 kW/l) specific input power. Comparative performance of various large-bore kinetically enhanced copper vapor lasers in the range 45-70 mm is presented for most suitable discharge tube. Maximum output power of ∼100 W was achieved with efficiency of about 1.55% at 10 kHz rep-rate from the 60 mm bore KE-CVL. The pulse to pulse efficiency of the KE-CVL was ∼2%, tube efficiency ∼2.1%, and laser pulse energy was about ∼10 mJ. These results show significant advancement in the laser system as an elemental high temperature CVL due to volumetric scaling and KE-effects combined with very low specific input power of ∼1.65 kW/l as compared to 8-9 kW/l normally required in other kinetically enhanced copper vapor lasers to generate ∼100 W output power. Performance of the KE-CVL with 3 new cavity configurations namely, (1) CAT-EYE resonator (2) hybrid resonator, and (3) modified diffraction coupled resonator with dot mirrors are presented for the first here. CAT-EYE resonator was demonstrated to achieve high misalignment tolerance without significant loss of power. A typical drift in power of ∼5% was observed with misalignment responsible for 40% decline in power in case of standard plane-plane cavity. Effect of resonator misalignment on amplifier output drift was also investigated using CAT-EYE resonator in oscillator-amplifier configuration. In case of using stable-unstable hybrid resonator, high magnification of M ∼ 1500 was realized resulting in extremely low divergence (∼0.08 mrad) beam with modest (∼20%) loss in average power. In case of modified DCR cavity, record power of about 48 W was achieved with beam divergence of about 0.1 mrad on using intra-cavity 2 × 2 array of 4 dot mirrors. 相似文献
105.
106.
Allen Ko Aaron Lam Jeffrey Li Edyta M. Greer David J. Szalda Sasan Karimi Gopal Subramaniam Keith Ramig 《Tetrahedron letters》2014
2,4-Diphenyl-3H-1-benzazepine is deprotonated with either LDA or KHMDS. The resulting anion is alkylated with alkyl halides or MeOTs, giving either products of alkylation at C3, or at N, or a mixture of both. The regioselectivity depends on the base, presence of the complexing agent HMPA, and the leaving group of the alkylating agent. Using MeI as alkylating agent gives exclusively the C3-methylated product, while using MeOTs gives exclusively the N-methylated product. The N-alkylated products show evidence of stereodynamic behavior in their NMR spectra. 相似文献
107.
108.
Jianqing Li Daniel Smith Subramaniam Krishnananthan Dauh-Rurng Wu Dawn Sun Peng Li Kristen Ryan Min Hu Wenge Cui Jennifer Naginskaya Shuang Liu Paul C. Lobben Alicia T. Ng Richard Olson Arvind Mathur 《Tetrahedron: Asymmetry》2017,28(1):196-202
BMS-911278 was identified as a potent triple reuptake inhibitor potentially useful for the treatment of depression. The original racemic synthesis suffered from tedious and low recovery resolution and HPLC separation, as well as low-yielding hazardous N-demethylation at the API step. To support further preclinical studies, a scalable enantioselective synthesis was developed. Herein, we report an efficient asymmetric synthesis of BMS-911278 featuring two key steps: an enantioselective Miyaura reaction and an intramolecular regioselective cyclization. 相似文献
109.
Safiah Ahmad Mubbarakh Safrina Rahmah Zuraida Abdul Rahman Nazrin Nadirah Mohd Sah Sreeramanan Subramaniam 《Applied biochemistry and biotechnology》2014,172(2):1131-1145
Cryopreservation is an alternative, safe, and cost-effective method for long-term plant genetic resource conservation. This study was conducted to optimize the conditions for cryopreserving the protocorm-like bodies (PLBs) of Brassidium Shooting Star orchid with the PVS3 vitrification method. Five parameters were assessed in this study: PLB size, sucrose concentration, preculture duration, PVS3 duration, and unloading duration. The viability of the cryopreserved PLBs was determined using the triphenytetrazolium chloride assay and growth recovery assessments. The optimum condition for the cryopreservation of the PLBs of Brassidium Shooting Star orchid is based on the size range between 3 and 4 mm precultured with half-strength semi-solid MS media supplemented with 0.25 M sucrose for 24 h, followed by treatment with loading solution mixture of 2 M glycerol and 0.4 M sucrose supplemented with half-strength liquid MS media at 25 °C for 20 min. The PLBs were then dehydrated with PVS3 at 0 °C for 20 min prior to immersion in liquid nitrogen; finally, the PLBs were immersed with half-strength liquid MS media supplemented with 1.2 M sucrose for 30 min. Histological analyses displayed denser cytoplasm and voluminous nucleus in the cryopreserved PLBs of Brassidium Shooting Star orchid. 相似文献
110.
Prema Subramaniam Tomoyoshi Sasakawa Tomiki Ikeda Shigeo Tazuke Mahalingam Srinivasan 《Journal of polymer science. Part A, Polymer chemistry》1987,25(6):1463-1474
Novel poly-Schiff bases (PSB's) that contain trans-1,2-bis(9-carbazolyl)cyclobutane(DCZB) units were synthesized by the direct polycondensation of trans-1,2-bis(3-formyl-9-carbazolyl)cyclobutane with aromatic diamines in n-amyl alcohol at 160°C. Complexation of these PSB's and of poly(vinyl DCZB) (PVDCZB) with iodine produced cation-radical salts which resulted form the transfer of an electron from DCZB moieties to iodine. All the undoped polymers were insulators having electrical conductivity of the order of 10?10–10?12 S cm?1 depending on the structure of polymers. By doping with iodine, the electrical conductivity increased by several orders of magnitude and reached a value of 10?3 S cm?1 in the case of PVDCZB and 10?5–10?6 S cm?1 in the case of PSB's. The electrical conductivity of doped PSB's increased with decreasing diamine length. PVDCZB having the same iodine content per carbazole unit as poly(9-vinyl-carbazole) (PVK) has a greater electrical conductivity than PVK. 相似文献