In this Letter, we describe the formation of complexes between flavin and diamidopyridine functionalized porphyrin systems via hydrogen bonding and π-stacking interactions. 相似文献
Malononitrile is a useful reagent for multicomponent reactions with hundreds of methods developed. In this paper, we suggest α-(cyano)-o-tolunitrile (homophtalonitrile) to work as a vinylogous malononitrile. Thus, a organocatalytic pseudo-three-component reaction of homopthalonitrile (2 equiv) and o-hydroxybenzaldehyde, leading to the diastereoselective formation of 5-amino-12H-chromeno[2,3-c]isoquinolin-12-yl)(cyano)methyl)benzonitriles, was discovered. The possibility to employ other nucleophiles was demonstrated for indoles, and a sequential three-component reaction of homophtalonitrile, o-hydroxybenzaldehyde, and (aza)indole, giving 12-(1H-Indol-3-yl)-12H-chromeno[2,3-c]isoquinolin-5-amines, was developed. The photophysical properties of the synthesized compounds have been studied, revealing high fluorescence quantum yields (42–70 %) for indol-3-yl substituted 12H-chromeno[2,3-c]isoquinolin-5-amines and reversible fluorescence quenching under acidic conditions. 相似文献
Near infrared quantum cutting by cooperative energy transfer from Tb3+ to Yb3+ was investigated by photoluminescence measurements on (YbxY1?x)PO4 (x = 0, 0.05, 0.1, 0.15) doped with 1 % Tb3+. Under the excitation of 473 and 486 nm continuous wave lasers, we found that one Tb3+ ion absorbed one blue photon with the transition from 5D4 to 7F5 (λ ~ 544 nm) and cooperatively transfer energy to Yb3+ ions, which is followed by the emission of two photons (λ ~ 980 nm). Application of cooperative energy transfer has prospects for increasing the energy efficiency of crystalline Si solar cells by photon doubling of the high energy part of the solar spectrum.
Flexible textile composites like woven Kevlar fabrics are widely used in high velocity impact (HVI) applications. Upon HVI they are subjected to both longitudinal tensile and transverse compressive loads. To understand the role of transverse properties, the single fiber and tow transverse compression response (SFTCR and TTCR) of Kevlar KM2 fibers are numerically analyzed using plane strain finite element (FE) models. A finite strain formulation with a minimum number of 84 finite elements is determined to be required for the fiber cross section to capture the finite strain SFTCR through a mesh convergence study. Comparison of converged numerical solution to the experimental results indicates the dominant role of geometric stiffening at finite strains due to growth in contact width. The TTCR is studied using a fiber length scale FE model of a single tow comprised of 400 fibers transversely loaded between rigid platens. This study along with micrographs of yarn after mechanical compaction illustrates fiber spreading and fiber–fiber contact friction interactions are important deformation mechanisms at finite strains. The TTCR is also studied using homogenized yarn level models with properties from the literature. Comparison of TTCR between fiber length scale and homogenized yarn length scale models indicate the need for a nonlinear material model for homogenized approaches to accurately predict the transverse compression response of the fabrics. 相似文献
Real-time scheduling problems confront two issues not addressed by traditional scheduling models, viz., parameter variability and the existence of complex relationships constraining the executions of jobs. Accordingly, modeling becomes crucial in the specification of scheduling problems in such systems. In this paper, we analyze scheduling algorithms in Partially Clairvoyant Real-time scheduling systems and present a new dual-based algorithm for the feasibility problem in the case of strict relative constraints. We also study the problem of online dispatching in Partially Clairvoyant systems and show that the complexity of dispatching is logarithmically related to the complexity of the schedulability problem. 相似文献
Abstract Imidazole-, 2-methyl imidazole-, and benzimidazole-blocked toluene diisocyanates (TDI) were prepared and characterized by elemental analysis, IR, and NMR spectroscopy. Simultaneous TGA/DTA results showed that the thermal stability of the adduct decreases in the following order: imidazole-TDI > 2-methylimidazole-TDI > benzimidazole-TDI. Gelation test involving imidazole-blocked adducts and hydroxyl-terminated polybutadiene were also carried out. The cure rate of the adduct increases from the imidazole- to the 2-methylimidazole- and to the benzimidazole-blocked adduct. It is also found that the benzimidazole-blocked adduct shows better solubility in the polyols. 相似文献
An efficient method for the asymmetric synthesis of 4H‐3,1‐benzoxazines was developed by kinetic resolution of 2‐amido benzyl alcohols using chiral phosphoric acid catalyzed intramolecular cyclizations. A broad range of benzyl alcohols (both secondary and tertiary alcohols) were kinetically resolved with high selectivities, with an s factor of up to 94. Mechanistic studies were performed to elucidate the mechanism of these reactions, wherein the amide moieties reacted as the electrophiles. Gram‐scale reaction and facile transformations of the chiral products demonstrate the potential of this method in asymmetric synthesis of biologically active chiral heterocycles. 相似文献
Fascinating dynamics is known to result when the flow rate Q at which water drips from a faucet varies. Starting with simple (period-1) dripping, the system transitions as Q increases to complex dripping, where it exhibits period-n (n=2,4, em leader ) and chaotic responses, and then jets once Q exceeds a threshold. New experiments and simulations show that high viscosity (micro) liquids, e.g., syrup, transition directly from simple dripping to jetting as Q increases. Phase diagrams showing transitions between simple and complex dripping and jetting in (Q,micro) space are developed. Values of Q for transition from dripping to jetting are estimated from scaling arguments and shown to accord well with simulations. 相似文献
Tumor suppressor protein p53 maintains integrity of genome and regulates the genes responsible for DNA repair mechanism, apoptosis as well as cell cycle and growth arrest. As with murine double minute 2 (MDM2), the human homolog HDM2 is a principal cellular antagonist of p53. In unstressed cells, cellular levels of p53 and HDM2 are maintained in an autoregulatory manner in which both mutually control cellular levels of each other. About half of the human cancers express wild-type p53 protein that is antagonized by over-expressed HDM2. Restoring p53 function via HDM2 antagonists is a leading therapeutic approach for treating a variety of tumors. In this study, we have developed a novel statistically sound group-based QSAR (GQSAR) model using piperidine-derived compounds that have been validated experimentally to inhibit p53–HDM2 interaction. On the basis of developed GQSAR model, a combinatorial library of molecules was prepared and its activity was predicted. These molecules were then docked to HDM2, and two top-scoring molecules possessing a binding energy of ?6.639 and ?6.305 kcal/mol were selected for further study. These molecules and their binding poses were analyzed further via molecular dynamic simulations. In this study, we report two lead compounds as potent HDM2 inhibitors and also provide an insight into mechanism of interaction of the lead compounds to HDM2 target.
A novel mixed metal complex, [Mn0.61Zn0.39(OOCCHNNH2)2(H2O)2] has been synthesized and characterized by hydrazine and metal analyses, CHN analyses, infrared spectra, simultaneous TG-DTA and single crystal X-ray diffraction studies. The structure of the complex has been determined by X-ray single crystal study which clearly reveals that the octahedral site is occupied by two metal ions (viz., Mn and Zn) around which two hydrazoneglyoxylate ligands (OOCCHNNH2) coordinate in a bidentate chelating fashion. Two water molecules occupy the remaining two other sites of a slightly distorted octahedron with C2 axis of symmetry. The infrared spectrum reveals the monodentate coordination behavior of carboxylate ions and coordination of water molecules. The simultaneous TG-DTA traces are in accordance with the formation of mixed metal oxide (spinel oxide) as an end product. The high resolution scanning electron microscopy (HRSEM) images show the presence of irregularly shaped agglomerated particles of sub-micron size. The zeta potential value for mixed metal oxide is ?33.1 mV, which indicates the stability of the oxide. 相似文献