Rheological changes occurring during the storage of the system sodium dodecyl sulphate/1-hexadecanol/water

Summary The physical decomposition of the system formed when sodium dodecyl sulphate, 1-hexadecanol and water are heated, mixed and cooled could be achieved at an accelerated rate by cycling the storage temperature between 5–7 °C and 20–25 °C. This decomposition caused the formation of pearliness and the systems became progressively more fluid with loss in rigidity.The changes in the rheological properties of the systems were investigated at 25 °C using a modifiedWeissenberg Rheogoniometer, anEpprecht Rheomat 15 viscometer, and a concentric cylinder air turbine viscometer.The systems are referred to by a code R_x where x is the molar ratio of 1-hexadecanol to sodium dodecyl sulphate. The systems R₁–R₁₀ were examined during temperature cycling for a maximum period of eight days. During this period, the systems R₁–R₄ progressively increased in consistency when examined in continuous shear using anEpprecht Rheomat 15, concentric cylinder viscometer. System R₅ was also examined using anEpprecht Rheomat 15, but after increasing in consistency up to the fourth day, thereafter decreased in consistency. Systems R₃ to R₁₀ were investigated in creep mode. For R₃ and R₄, the compliance progressively decreased over a period of eight days, whereas for systems R₅–R₈ compliance was found to pass through a minimum about four days after preparation and the start of temperature cycling. Thereafter it increased. For R₉ and R₁₀, the creep compliance at one hour increased continuously during the eight day period.

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Zusammenfassung Beschleunigte Zersetzung des Systems, das beim Erwärmen, Mischen und Kühlen von Natriumdodecylsulfat, 1-Hexadekanol und Wasser entsteht, wurde durch zyklische Temperaturänderungen zwischen 5–7 und 20–25 °C bewirkt. Durch Zersetzung wurde das System perlmutterartig verfärbt und unter Verlust an Festigkeit fließfähiger.Die Änderungen im rheologischen Verhalten wurden mit einem modifiziertenWeissenberg-Rheogoniometer, einem Rheomat-15-Viskosimeter, und einem Luftturbinen-Viskosimeter mit konzentrischen Zylindern untersucht.Auf die verschiedenen Systeme wird mit einem Code R_x Bezug genommen, wobei x das molare Verhältnis von 1-Hexadekanol zu Natriumdodecylsulfat ist. Die Systeme R₁–R₁₀ wurden über einen Zeitraum von 8 Tagen unter dem Einfluß von zyklischen Temperaturänderungen untersucht. Innerhalb dieses Zeitraumes nahmen die flüssigen Systeme R₁–R₄, wie kontinuierliche Scherexperimente mit dem Rheomat 15 Viskosimeter (konzentrische Zylinder) zeigten, beständig an Konsistenz zu. System R₅ wurde auch mit dem Rheomat 15 untersucht; es zeigte aber, nach einer Konsistenzzunahme bis zum 4. Tag, eine Abnahme an Konsistenz. Die Systeme R₆–R₁₀, die mehr Festkörper-Charakter hatten, wurden mit Hilfe von Kriechtesten untersucht. Die dynamische Nachgiebigkeit bei 1 Std. ging durch ein Minimum 4 Tage nach der Herstellung bei Lagerung mit zyklischer Temperaturänderung. Danach nimmt sie zu. Für R₉–R₁₀ nahm die dynamische Nachgiebigkeit bei 1 Std. kontinuierlich über die 8 Tage zu.

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Paper presented to the British Society of Rheology Conference on Rheology in Medicine and Pharmacy, London, April 14–15, 1970.     

Bounds on the CP asymmetry in like-sign dileptons from B(0)B*(0) meson decays

We have measured the charge asymmetry in like-sign dilepton yields from B(0)B*(0) meson decays using the CLEO detector at the Cornell Electron Storage Ring. We find a(0)(ll) identical with[N(l(+)l(+))-N(l(-)l(-))]/[N(l(+)l(+))+N(l(-)l(-))] = +0.013+/-0.050+/-0.005. We combine this result with a previous, independent measurement and obtain Re(epsilon(B))/(1+ the absolute value of epsilon(B)(2)) = +0.0035+/-0.0103+/-0.0015 (uncertainties are statistical and systematic, respectively) for the CP impurity parameter, epsilon(B).     

On-line, real time monitoring of exhaled trace gases by SIFT-MS in the perioperative setting: a feasibility study

A study is described of the first on line, real time analyses of the exhaled breath of five anaesthetized patients during the complete perioperative periods of laparoscopic surgery. These breath analyses were achieved using a selected ion flow tube, SIFT-MS, instrument, located in the operating theatre at an acceptable distance from the operating table, and coupled to the endotracheal tube in the ventilation circuit via a 5 metre long capillary tube. Thus, inhalation/exhalation breathing cycles, set to be at a frequency of 10 per minute, were sampled continuously for water vapour, the metabolites acetone and isoprene and the propofol used to induce anaesthesia for each operating period that ranged from 20 min (shortest) to 80 min (longest). Whilst there was some loss of water vapour along the long sampling line, the concentrations of the other trace compounds were not diminished. The breath acetone was essentially at a constant level for each patient, but increased somewhat over the longest operating period due to the onset of lipolysis. Most interesting is the clear increase of breath isoprene following abdomen inflation with carbon dioxide. The vapour of the intravenously injected propofol was detected in the exhaled breath and remained essentially constant during the perioperative period. These analyses were performed totally non-invasively and the data were immediately and constantly available to the anaesthetist and surgeon. Exploitation of this development could influence decision making and potentially improve patient safety within the perioperative setting.     

Succinct and Facile Synthesis of Innovative Thiopyrimidines With Antimicrobial and Antitubercular Investigation

Abstract

To develop a series of bioactive heterocycles in minimum number of steps, 3-methyl- 4-(substituted phenyl)-1-phenyl-4,8-dihydropyrazolo[4′,3′:5,6]pyrano[2,3-d]pyrimidine-5,7 (1H,6H)-dithione 2(a–j), 4-(4-substituted phenyl)-5-imino-3-methyl-1,6-diphenyl-4,5,6,8-tetrahydropyrazolo[4′,3′:5,6]pyrano[2,3-d]pyrimidine-7(1H)-thione 3(a–j), and N-[4-(subs- tituted phenyl)-3-methyl-1-phenyl-7-thioxo-1,4,7,8-hexahydropyrazolo[4′,3′:5,6]pyrano[2,3-d]pyrimidine-5-yl]thiourea 4(a–j) have been synthesized from amino nitrile functionality 1(a–j). The structures of the compounds were elucidated by IR, ¹H NMR, elemental analysis, and some representative ¹³C NMR and mass spectra. All the title compounds were screened for antimicrobial and antitubercular activities, while some representative compounds were tested for antioxidant activity. Out of synthesized compounds, compounds 1j (4-CH₃), 2d (4-F), 4c (4-OH), and 4i (3-Br) exhibited maximum inhibition against Mycobacterium Tuberculosis H₃₇Rv. Compound 3c (4-OH) revealed elevated efficacy against all tested bacterial strain, while compounds 1i (3-Br), 2c (4-OH), and 3h (3-NO₂) were found efficacious against Candida albicans as compared to standard drugs.

Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.     

Synthesis of Functionalized H‐[1]Benzopyrano[2,3‐b]pyridines by the Friedländer Approach: Antimycobacterial and Antimicrobial Profile

A series of functionalized H‐[1]benzopyrano[2,3‐b]pyridine derivatives were synthesized by the Friedländer reaction of 2‐amino‐4‐oxo‐4H‐chromene‐3‐carbonitriles 1 with malononitrile, ethyl cyanoacetate, or acetophenone (Scheme). The synthesized compounds 2 – 4 were screened for their in vitro activity against antitubercular, antibacterial, and antifungal species (Fig., Table). Among the synthesized compounds, 3c and 4f were the most active with 99% inhibition against Mycobacterium tuberculosis H₃₇Rv, while compounds 2f, 3f , and 4d exhibited 69%, 63%, and 61% inhibition, respectively. The 4‐amino‐7,9‐dibromo‐1,5‐dihydro‐2,5‐dioxo‐2H‐chromeno[2,3‐b]pyridine‐3‐carbonitrile ( 3b ) showed the most potent antibacterial activity against Escherichia coli and Pseudomonas aeruginosa. Several chromeno[2,3‐b]pyridine derivatives showed equal or more potency against Staphylococcus aureus and Candida albicans.     

First on-line test of the LINAC superbuncher at nuclear science centre

An on-line test of the LINAC superbuncher at Nuclear Science Centre has been successfully performed. DC O⁷⁺ beam of nominal energy 92 MeV was accelerated through the superbuncher resonator, operating at a field of 4.54 MV/m. The total energy gain of the beam was measured to be 4.5 MeV. For the pulsed beam test a phase locked bunched beam of O⁷⁺ of nominal energy 92 MeV, FWHM 1.3 ns from the pre-tandem multiharmonic buncher was injected into the superbuncher. By properly adjusting the phase and amplitude of the resonator, the best FWHM of the bunched beam was measured to be 185 ps near the entrance of the first LINAC module. Fully depleted cooled surface barrier detector was used for measuring the time width. In a separate experiment the intrinsic time resolution of the same detector was measured to be 134 ps. Consequently the intrinsic time width of the bunched beam, after correcting for the detector resolution, would be 127 ps. Details of the experiment and results are presented.     

The pH dependent interaction between nicotine and simulated pulmonary surfactant monolayers with associated molecular modelling

Pulmonary surfactant is an endogenous material that lines and stabilises the alveolar air–liquid interface. Respiratory mechanics can be compromised by exposure to environmental toxins such as cigarette smoke, which contains nicotine. This study aims to determine the influence of nicotine on the activity of simulated lung surfactant at pH 7 and pH 9. In all cases, the addition of nicotine to the test zone caused deviation in surfactant film performance. Importantly, the maximum surface pressure was reduced for each system. Computational modelling was applied to assess key interactions between each species, with the Gaussian 09 software platform used to calculate electrostatic potential surfaces. Modelling data confirmed either nicotine penetration into the two‐dimensional structure or interfacial/electrostatic interactions across the underside. The results obtained from this study suggest that nicotine can impair the ability of pulmonary surfactant to reduce the surface tension term, which can increase the work of breathing. When extrapolated to gross lung function, alveolar collapse and respiratory disease (e.g. chronic airway obstruction) may result. The delivery of nicotine to the (deep) lung can cause a deterioration in lung function and lead to reduced quality of life. Copyright © 2017 John Wiley & Sons, Ltd.     

The asymmetric Maitland-Japp reaction and its application to the construction of the C1-C19 bis-pyran unit of phorboxazole B

The synthesis of the C1-C19 bis-pyran unit of phorboxazole B has been achieved. The key pyran rings were constructed by means of an asymmetric Maitland-Japp reaction and a second Maitland-Japp resolution/cyclization reaction. The longest linear sequence was 14 steps, and the C1-C19 bis-pyran unit was formed in an impressive 10.4% yield.     

Evaluation and solubility improvement of Carvedilol: PSC[n]arene inclusion complexes with acute oral toxicity studies

The aqua phobic molecules that are practically insoluble in aqueous media demonstrate a staggeringly slow intrinsic dissolution rate. In this work, we exemplify the utility of calixarenes as a tool to form inclusion complexes with Carvedilol (CDL). It is poorly water soluble drug. CDL is a Biopharmaceutical Classification System (BCS) Class II drug and it is a nonselective β-adrenegenic blocking agent with α1-blocking activity. It is mainly used in the management of hypertension. The maximum complexation of the drug was accomplished after 48?h of stirring with para sulphonato calix[4]arene (PSC[4]arene) and para sulphonato calix[6]arene (PSC[6]arene) in water and evaporation of water to acquire solid complexes. The study includes characterisation of both the complexes—physical mixtures of drug and PSC[4]arene and PSC[6]arenes by different methods like Fourier-transform infra red spectroscopy, differential scanning calorimetry and powder X-ray diffraction, proton nuclear magnetic resonance. This studies shows that there is electrostatic interaction between drug and PSC[n]arenes. The complexation was determined by phase solubility study. The prepared complexes exhibited improved in vitro dissolution profile and decreased in vivo acute oral toxicity compared to the pure drug.     

Observation of the binary coalescence and equilibration of micrometer-sized droplets of aqueous aerosol in a single-beam gradient-force optical trap

The binary coalescence of aqueous droplets has been observed in a single-beam gradient-force optical trap. By measuring the time-dependent intensity for elastic scattering of light from the trapping laser, the dynamics of binary coalescence have been examined and the time scale for equilibration of a composite droplet to ambient conditions has been determined. These data are required for modeling the agglomeration of aqueous droplets in dense sprays and atmospheric aerosol. Elastic-light scattering from optically trapped particles has not been used previously to study the time-resolved dynamics of mixing. It is shown to offer a unique opportunity to characterize the binary coalescence of aqueous droplets with radii from 1 to 6 μm. The study of this size regime, which cannot be achieved by conventional imaging methods, is critical for understanding the interactions of droplets in the environment of dense sprays.