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31.
Stphane Baeriswyl Sacha Javor Achim Stocker Tamis Darbre Jean‐Louis Reymond 《Helvetica chimica acta》2019,102(9)
Dendrimers are regularly branched molecular trees which are notoriously difficult to crystallize. Herein we report the crystal structure of a C‐fucosylated second generation peptide dendrimer as complex with lectin LecB in which the only dendrimer‐lectin contact is the LecB bound glycoside (PDB 6S5S). In contrast to a previously reported crystal structure of a first‐generation peptide dendrimer as LecB complex in which the dendrimer formed trimers connected by intermolecular β‐sheets (PDB 5D2A), the present structure features a globular monomeric state held together by intramolecular backbone hydrogen bonds and assembled into a non‐covalent dimer stabilized by hydrophobic contacts between leucine side‐chains and proline‐phenylalanine CH‐π stacking interactions. Molecular dynamics and circular dichroism studies suggest that this crystal structure resembles the structure of the peptide dendrimer in solution. Structures of a partially resolved dendrimer (PDB 6S5R) and of C‐fucosylated disulfide bridged peptide dimers connecting different LecB tetramers are also reported (PDB 6S7G, PDB 6S5P). 相似文献
32.
Rameshwar U. Kadam Myriam Bergmann Matthew Hurley Divita Garg Martina Cacciarini Magdalena A. Swiderska Cristina Nativi Michael Sattler Alan R. Smyth Paul Williams Miguel Cmara Achim Stocker Tamis Darbre Jean‐Louis Reymond 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2011,123(45):10819-10823
33.
The de novo synthesis of an aceric acid thioglycoside building block and the total synthesis of the plant carbohydrate aceric acid are described via a highly convergent strategy. Aldol reaction of acetaldehyde and a protected tartaric acid derivative provided the open chain carbohydrate. Subsequent acid treatment yielded the aceric acid thioglycoside in 35% total yield over five steps. Oxidative cleavage of the thioketal in the open chain carbohydrate and basic hydrolysis of the methyl ester furnished fully deprotected aceric acid in 31% yield over six steps. 相似文献
34.
The synthesis of a core arabinomannan (AM) oligosaccharide from Mycobacterium tuberculosis has been achieved using a convergent [6 + 6] glycosylation strategy and a defined set of building blocks. Dodecasaccharide 1, containing the key AM structural features of lipoarabinomannan (LAM), was obtained in excellent yield and selectivity from hexamannan 3 and hexaarabinan 5. This flexible synthetic strategy involves late-stage couplings and modifications, thus providing ready access to several different LAM fragments. The incorporation of a thiol linker at the reducing end of the oligosaccharide allows for the attachment of these compounds to microarrays and protein carriers. 相似文献
35.
Leila Douifi Jacques Raffi Pierre Stocker François Dole 《Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy》1998,54(14):2403-2412
This paper makes a point about the identification of irradiated foodstuffs by means of electron paramagnetic resonance (EPR) or electron spin resonance (ESR). EPR is the most accurate method for such routine applications since radicals are stabilised for a long time in all (or part of) foods that are in solid and dry states; consequently, EPR can be applied to meat and fish bones, fruit and relative products (from vegetal origin). More details are given for mollusc shells, such as oysters and mussels. 相似文献
36.
W. Stocker 《Nuclear Physics A》1973,215(3):591-597
The term in the nuclear mass formula is studied. The curvature correction is investigated within the framework of the energy density formalism; the compression term is evaluated from a phenomenological point of view. The results are in fair agreement with the droplet model values obtained by Myers and Swiatecki. 相似文献
37.
The differential susceptibility of double transition spin glass - ferromagnets is calculated as a function of temperature and external field based upon the theory by Sherrington and Kirkpatrick. Good agreement with experiments on the FeMn system has been obtained. 相似文献
38.
A potential consisting of the modified surface-delta interaction plus a tensor force is fitted to the 15 empirical two-body matrix elements of the upper s-d shell and, independently, to 12 two-body matrix elements of the
shells. 相似文献
39.
Ohne Zusammenfassung 相似文献
40.
Stowers MA van Wuijckhuijse AL Marijnissen JC Scarlett B van Baar BL Kientz CE 《Rapid communications in mass spectrometry : RCM》2000,14(10):829-833
Matrix-assisted laser desorption/ionization (MALDI) mass spectra were obtained from single biological aerosol particles using an aerosol time-of-flight mass spectrometer (ATOFMS). The inlet to the ATOFMS was coupled with an evaporation/condensation flow cell that allowed the aerosol to be coated with matrix material as the sampled stream entered the spectrometer. Mass spectra were generated from aerosol composed either of gramicidin-S or erythromycin, two small biological molecules, or from aerosolised spores of Bacillus subtilis var niger. Three different matrices were used: 3-nitrobenzyl alcohol, picolinic acid and sinapinic acid. A spectrum of gramicidin-S was generated from approximately 250 attomoles of material using a molar ratio of 3-nitrobenzyl alcohol to analyte of approximately 20:1. A single peak, located at 1224 Da, was obtained from the bacterial spores. The washing liquid and extract solution from the spores were analyzed using electrospray mass spectrometry and subsequent MS/MS product ion experiments. This independent analysis suggests that the measured species represents part of the B. subtilis peptidoglycan. The on-line addition of matrix allows quasi-real-time chemical analysis of individual, aerodynamically sized particles, with an overall system residence time of less than 5 seconds. These results suggest that a MALDI-ATOFMS can provide nearly real-time identification of biological aerosols. Copyright 2000 John Wiley & Sons, Ltd. 相似文献