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241.
I T Vieira P R Harper A K Shahani V De Senna 《The Journal of the Operational Research Society》2003,54(7):713-722
Mother-to-child transmission (MTCT) of HIV is the most significant source of HIV infection in children below the age of 15 years. In 2000 alone, about 600 000 new infections occurred, the vast majority from mothers living in developing countries who were not aware of their HIV-positive status. To date, at least 4.3 million children have died from AIDS. In this paper, we discuss the development of an operational model that can be used to evaluate intervention options for the prevention of MTCT of HIV. The problem was approached by defining suitable pregnancy risk groups, prevention options and the required model outputs to evaluate different intervention strategies. The method chosen to approach the problem was a discrete-event, three-phase simulation, built in Visual Basic, with a stochastic semi-Markov structure. The developed model takes individual pregnant women through each stage of their pregnancy, labour and birth. Different intervention strategies may be modelled at any time, including short-course antiretroviral drugs and cessation of breastfeeding. The model is demonstrated with data from Botswana, which has one of the highest HIV-infection rates in the world. 相似文献
242.
243.
Alick KT Law Deepak Gupta Shawn Levy Douglas C Wallace Robert J McKeon Charles R Buck 《BMC neuroscience》2004,5(1):1
Background
The adenine nucleotide translocator 1 (Ant1) is an inner mitochondrial membrane protein involved with energy mobilization during oxidative phosphorylation. We recently showed that rodent Ant1 is upregulated by transforming growth factor-beta (TGF-β) in reactive astrocytes following CNS injury. In the present study, we describe the molecular mechanisms by which TGF-β1 regulates Ant1 gene expression in cultured primary rodent astrocytes. 相似文献244.
Mieko Tanaka-Yamawaki 《Annals of the Institute of Statistical Mathematics》2003,55(2):437-446
Contrary to the common sense in economics and financial engineering, price fluctuations at very fine level of motion exhibit
various evidences against the efficient market hypothesis. We attempt to investigate this issue by studying extensive amount
of foreign currency exchange data for over five years at the finest level of resolution. We specifically focus on the proposed
stability in binomial conditional probabilities originally found in much smaller examples of financial time series. In order
to handle very large data, we have written an efficient program in C that automatically generates those conditional probabilities.
It is found that the stability is maintained for extremely large time duration that covers almost the entire period. Based
on the length of conditions for which the conditional probabilities are distinguishable each other, we identify the length
of memory being less than 3 movements. 相似文献
245.
All homothetic self-similar solutions of the Brans-Dicke scalar field in three-dimensional spacetime with circular symmetry
are found in closed form. 相似文献
246.
Fabio Scardigli 《Foundations of Physics》2007,37(8):1278-1295
The Titius–Bode law for planetary distances is reviewed. A model describing the basic features of this rule in the “quantum-like”
language of a wave equation is proposed. Some considerations about the ’t Hooft idea on the quantum behavior of deterministic
systems with dissipation are discussed. 相似文献
247.
Below a critical thickness, of about 60 nm, the glass transition temperature of polystyrene (PS) films decreases with film thickness, as demonstrated using free‐standing films. A geometrical model is developed here describing this phenomenon in the case of ideal (Gaussian) chains. This model, which can be considered as an application of the free volume model, assumes that the decrease of the glass transition temperature from thick to ultrathin films is due to the modification of the interpenetration between neighboring chains. The theoretical curve deduced from the model is in excellent agreement with the PS experimental results, without using any adjustable parameters. From these results, it can be concluded that new chain motions, usually buried in bulk samples, are expressed by the presence of the surface. © 2006 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 45: 10–17, 2007 相似文献
248.
We study the metrical theory of fibred systems, in particular, in the case of continued fraction mixing systems. We get the
limit distribution of the largest value of a continued fraction mixing stationary stochastic process with infinite expectation
and some related results. These are analogous to J. Galambos, W. Philipp, and H. G. Diamond–J. D. Vaaler theorems for the
regular continued fractions. As an application, we see that these theorems hold for Jacobi-Perron algorithm.
Received September 30, 2001; in revised form January 8, 2002 相似文献
249.
The shock structure problem is one of the classical problems of fluid mechanics and at least for non-reacting dilute gases it has been considered essentially solved. Here we present a few recent findings, to show that this is not the case. There are still new physical effects to be discovered provided that the numerical technique is general enough to not rule them out a priori. While the results have been obtained for dense fluids, some of the effects might also be observable for shocks in dilute gases. 相似文献
250.
It is shown that time-dependent temperatures in a transient, conductive system can be approximately modeled by a fractional-order
differential equation, the order of which depends on the Biot number. This approximation is particularly suitable for complex
shapes for which a first-principles approach is too difficult or computationally time-consuming. Analytical solutions of these
equations can be written in terms of the Mittag-Leffler function. The approximation is especially useful if a suitable fractional-order
controller is to be designed for the system. 相似文献