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151.
Kay Hettrich Wolfgang Wagenknecht Bert Volkert Steffen Fischer 《Macromolecular Symposia》2008,262(1):162-169
Regioselectively substituted cellulose sulfates in C2/3-, C2/6-, or C6-position of the anhydroglucose unit are accessible by certain synthesis routes. Thereby, products with different properties and various application areas are resulted. Important characteristics of cellulose sulfates regarding their applications are solubility (e.g. in water), rheological behavior, different interaction with low or high molecular cations, thermo reversible gel formation, enzymatic degradability, anticoagulant and antiviral activity. In C6-position substituted cellulose sulfates can be synthesized in principle by acetosulfation. The acetosulfation is a quasi-homogeneous synthesis proceeding under gradually dissolution of the cellulose by using different reactivity of the primary and secondary OH-groups as soon as converting cellulose acetate sulfates. After precipitation of the polymer the acetyl groups are cleaved in alkaline solution. The focus of our study was firstly the investigation of the acetosulfation in different polar aprotic solvents by various sulfating and acetylating agents. In general it should be investigated if C6 substituted cellulose sulfates can be obtained by acetosulfation with different solvents and agents. The products were characterized by 13C-NMR and Raman spectroscopy. 相似文献
152.
Renner S Derksen S Radestock S Mörchen F 《Journal of chemical information and modeling》2008,48(2):319-332
Improving the scoring functions for small molecule-protein docking is a highly challenging task in current computational drug design. Here we present a novel consensus scoring concept for the prediction of binding modes for multiple known active ligands. Similar ligands are generally believed to bind to their receptor in a similar fashion. The presumption of our approach was that the true binding modes of similar ligands should be more similar to each other compared to false positive binding modes. The number of conserved (consensus) interactions between similar ligands was used as a docking score. Patterns of interactions were modeled using ligand receptor interaction fingerprints. Our approach was evaluated for four different data sets of known cocrystal structures (CDK-2, dihydrofolate reductase, HIV-1 protease, and thrombin). Docking poses were generated with FlexX and rescored by our approach. For comparison the CScore scoring functions from Sybyl were used, and consensus scores were calculated thereof. Our approach performed better than individual scoring functions and was comparable to consensus scoring. Analysis of the distribution of docking poses by self-organizing maps (SOM) and interaction fingerprints confirmed that clusters of docking poses composed of multiple ligands were preferentially observed near the native binding mode. Being conceptually unrelated to commonly used docking scoring functions our approach provides a powerful method to complement and improve computational docking experiments. 相似文献
153.
Hausdorf S Wagler J Mossig R Mertens FO 《The journal of physical chemistry. A》2008,112(33):7567-7576
The contributions of terephthalic acid and Zn(2+)-coordinated water in N,N-diethylformamide (DEF) to the overall proton activity in the synthesis of MOF-5 (Zn4O(BDC)3, BDC = 1,4-benzenedicarboxylate) were quantitatively determined by combined electrochemical and UV-vis spectroscopic measurements. Structural transformations of zinc carboxylate-based metal organic frameworks due to their exposure to environments with variable water concentrations and the chemical means necessary to revert these transitions have been investigated. It was found that the water-induced structural transition of MOF-5 to the hydroxide structure Zn3(OH)2(BDC)2 x 2 DEF (MOF-69c) can be reverted by a thermal treatment of the obtained compound and its subsequent exposure to anhydrous DEF. MOF-5 syntheses from simple carboxylates as well as a water-free synthesis based on nitrate decomposition are presented. The latter demonstrates that nitrate can serve as the sole source for the oxide ion in MOF-5. 相似文献
154.
155.
Tsvetan Tarnev Steffen Cychy Corina Andronescu Martin Muhler Wolfgang Schuhmann Yen‐Ting Chen 《Angewandte Chemie (International ed. in English)》2020,59(14):5586-5590
A universal nano‐capillary based method for sample deposition on the silicon nitride membrane of liquid‐cell transmission electron microscopy (LCTEM) chips is demonstrated. It is applicable to all substances which can be dispersed in a solvent and are suitable for drop casting, including catalysts, biological samples, and polymers. Most importantly, this method overcomes limitations concerning sample immobilization due to the fragility of the ultra‐thin silicon nitride membrane required for electron transmission. Thus, a straightforward way is presented to widen the research area of LCTEM to encompass any sample which can be externally deposited beforehand. Using this method, NixB nanoparticles are deposited on the μm‐scale working electrode of the LCTEM chip and in situ observation of single catalyst particles during ethanol oxidation is for the first time successfully monitored by means of TEM movies. 相似文献
156.
Johannes Bitzer Steffen Otterbach Kavipriya Thangavel Anastasia Kultaeva Prof. Dr. Rochus Schmid Prof. Dr. Andreas Pöppl Prof. Dr. Wolfgang Kleist 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(25):5667-5675
Metal–organic frameworks containing multiple metals distributed over crystallographically equivalent framework positions (mixed-metal MOFs) represent an interesting class of materials, since the close vicinity of isolated metal centers often gives rise to synergistic effects. However, appropriate characterization techniques for detailed investigations of these mixed-metal metal–organic framework materials, particularly addressing the distribution of metals within the lattice, are rarely available. The synthesis of mixed-metal FeCuBTC materials in direct syntheses proved to be difficult and only a thorough characterization using various techniques, like powder X-ray diffraction, X-ray absorption spectroscopy and electron paramagnetic resonance spectroscopy, unambiguously evidenced the formation of a mixed-metal FeCuBTC material with HKUST-1 structure, which contained bimetallic Fe−Cu paddlewheels as well as monometallic Cu−Cu and Fe−Fe units under optimized synthesis conditions. The in-depth characterization showed that other synthetic procedures led to impurities, which contained the majority of the applied iron and were impossible or difficult to identify using solely standard characterization techniques. Therefore, this study shows the necessity to characterize mixed-metal MOFs extensively to unambiguously prove the incorporation of both metals at the desired positions. The controlled positioning of metal centers in mixed-metal metal–organic framework materials and the thorough characterization thereof is particularly important to derive structure–property or structure–activity correlations. 相似文献
157.
Paweł Wyżga Igor Veremchuk Matej Bobnar Primož Koželj Steffen Klenner Rainer Pöttgen Andreas Leithe-Jasper Roman Gumeniuk 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(23):5245-5256
The homogeneity range of ternary iron indium thiospinel at 873 K was investigated. A detailed study was focused on two distinct series (y=z): 1) a previously reported charge-balanced (In0.67+0.33y□0.33−0.33y)tetr[In2−zFez]octS4 (A1-series; □ stands for vacancy; the abbreviations “tetr” and “oct” indicate atoms occupying tetrahedral 8a and octahedral 16d sites, respectively) and 2) a new charge-unbalanced (In0.67+y□0.33−y)tetr[In2−zFez]octS4 (A2-series). Fe atoms were confirmed to exclusively occupy an octahedral position in both series. An unusual reduction of the unit cell parameter with increasing Fe content is explained by differences in the ionic radii between Fe and In, as well as by an additional electrostatic attraction originating from charge imbalance (latter only in A2-series). The studied compound is an n-type semiconductor, and its charge carrier concentration increases or decreases for larger Fe content within the A1- and A2-series, respectively. The thermal conductivity κtot is significantly reduced upon increasing vacancy concentration, whereas the change of power factor is insufficient to drastically improve the thermoelectric figure of merit. 相似文献
158.
Agus R. Poerwoprajitno Dr. Lucy Gloag Dr. John Watt Steffen Cychy Dr. Soshan Cheong Dr. Priyank V. Kumar Dr. Tania M. Benedetti Chen Deng Dr. Kuang-Hsu Wu Dr. Christopher E. Marjo Dr. Dale L. Huber Dr. Martin Muhler Prof. Dr. J. Justin Gooding Prof. Dr. Wolfgang Schuhmann Prof. Dr. Da-Wei Wang Prof. Dr. Richard D. Tilley 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(36):15615-15620
159.
Dr. Dennis Kubiczek Heinz Raber Dr. Nicholas Bodenberger Thomas Oswald Melis Sahan Daniel Mayer Dr. Sebastian Wiese Prof. Dr. Steffen Stenger Prof. Dr. Tanja Weil Dr. Frank Rosenau 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(64):14536-14545
Textbook procedures require the use of individual aptamers enriched in SELEX libraries which are subsequently chemically synthesized after their biochemical characterization. Here we show that this reduction of the available sequence space of large libraries and thus the diversity of binding molecules reduces the labelling efficiency and fidelity of selected single aptamers towards different strains of the human pathogen Pseudomonas aeruginosa compared to a polyclonal aptamer library enriched by a whole-cell-SELEX involving fluorescent aptamers. The library outperformed single aptamers in reliable and specific targeting of different clinically relevant strains, allowed to inhibit virulence associated cellular functions and identification of bound cell surface targets by aptamer based affinity purification and mass spectrometry. The stunning ease of this FluCell-SELEX and the convincing performance of the P. aeruginosa specific library may pave the way towards generally new and efficient diagnostic techniques based on polyclonal aptamer libraries not only in clinical microbiology. 相似文献
160.
Donna S. Amenta John W. Gilje Frank T. Edelmann Steffen Blaurock 《Journal of organometallic chemistry》2006,691(23):5065-5068
The reaction of with p-CH3C6H4S(O)2O(CH2)3C6H5 produces (η5-C5H5)(OC)3Mo(CH2)3C6H5. This is only the second structurally characterized organometallic species in which an aromatic moiety is separated by three or more methylene groups. The alkyl chain adopts a staggered conformation, the Mo-C(1)-C(2)-C(3)-C(4) unit is nearly coplanar, and the alkyl chain eclipses the trans-carbonyl group on Mo. NMR evidence indicates that this conformation is preserved in solution. 相似文献