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81.
Marchese S Curini R Gentili A Perret D Rocca LM 《Rapid communications in mass spectrometry : RCM》2004,18(3):265-272
A simple and rapid method using reversed-phase liquid chromatography/tandem mass spectrometry (LC/MS/MS) for the simultaneous determination of the urinary metabolites of benzene, toluene, xylene and styrene in human urine specimens and standard solutions is described. A hybrid quadrupole/time-of-flight (QqTOF) mass spectrometer was compared for the determination of metabolite of aromatic solvents in urine samples. The metabolites selected were: trans,trans-muconic acid, hippuric acid, o-, m- and p-methylhippuric acid and phenylglyoxylic acid. The compounds were well separated from each other on narrow-bore 1-mm i.d. reversed-phase LC C-18 columns. Average recoveries for loading 100 microL of urine samples varied from 88-110% and the quantification limits were less than 30 ng/mL for each analyte (3 ng/mL for trans,trans-muconic acid). The qualitative information obtained (mass accuracy, resolution and full-scan spectra) with the QqTOF mass spectrometer allows a secure identification of analytes in biological matrices. 相似文献
82.
The structure of a 1,7,7-triaryl norbornane (compound 3) has been determined by X-ray diffraction and was found essentially equal to that predicted by molecular mechanics calculations. Restricted rotation of the aryl groups also has been observed by dynamic NMR spectroscopy in this compound and in a number of analogously substituted norbornanes. The aryl-norbornane bond rotation barriers were measured by line shape analysis of the (13)C NMR spectra obtained at temperatures lower than -100 degrees C and were found to cover the range 6.0 to 7.9 kcal mol(-1). An exception was the rotation involving the o-anisyl group in compound 5, which occurs near ambient temperature since the corresponding barrier is much higher (14.4 kcal mol(-1)). In one case (compound 4) configurational enantiomers could be separated by chiral HPLC and the corresponding CD spectra recorded. 相似文献
83.
Boseggia E Gatos M Lucatello L Mancin F Moro S Palumbo M Sissi C Tecilla P Tonellato U Zagotto G 《Journal of the American Chemical Society》2004,126(14):4543-4549
A series of cis-cis-triaminocyclohexane Zn(II) complex-anthraquinone intercalator conjugates, designed in such a way to allow their easy synthesis and modification, have been investigated as hydrolytic cleaving agents for plasmid DNA. The ligand structure comprises a triaminocyclohexane platform linked by means of alkyl spacers of different length (from C(4) to C(8)) to the anthraquinone group which may intercalate the DNA. At a concentration of 5 microM, the complex of the derivative with a C(8) alkyl spacer induces the hydrolytic stand scission of supercoiled DNA with a rate of 4.6 x 10(-6) s(-1) at pH 7 and 37 degrees C. The conjugation of the metal complex with the anthraquinone group leads to a 15-fold increase of the cleavage efficiency when compared with the anthraquinone lacking Zn-triaminocyclohexane complex. The straightforward synthetic procedure employed, allowing a systematic change of the spacer length, made possible to gain more insight on the role of the intercalating group in determining the reactivity of the systems. Comparison of the reactivity of the different complexes shows a remarkable increase of the DNA cleaving efficiency with the length of the spacer. In the case of too-short spacers, the advantages due to the increased DNA affinity are canceled due to the incorrect positioning of the reactive group, thus leading to cleavage inhibition. 相似文献
84.
S Monari G Battistuzzi CA Bortolotti S Yanagisawa K Sato C Li I Salard D Kostrz M Borsari A Ranieri C Dennison M Sola 《Journal of the American Chemical Society》2012,134(29):11848-11851
The hydrophobic patch of azurin (AZ) from Pseudomonas aeruginosa is an important recognition surface for electron transfer (ET) reactions. The influence of changing the size of this region, by mutating the C-terminal copper-binding loop, on the ET reactivity of AZ adsorbed on gold electrodes modified with alkanethiol self-assembled monolayers (SAMs) has been studied. The distance-dependence of ET kinetics measured by cyclic voltammetry using SAMs of variable chain length, demonstrates that the activation barrier for short-range ET is dominated by the dynamics of molecular rearrangements accompanying ET at the AZ-SAM interface. These include internal electric field-dependent low-amplitude protein motions and the reorganization of interfacial water molecules, but not protein reorientation. Interfacial molecular dynamics also control the kinetics of short-range ET for electrostatically and covalently immobilized cytochrome c. This mechanism therefore may be utilized for short-distance ET irrespective of the type of metal center, the surface electrostatic potential, and the nature of the protein-SAM interaction. 相似文献
85.
Alain?DelgadoEmail author Stefano?Corni Guido?Goldoni 《Theoretical chemistry accounts》2012,131(2):1115
We report on ab-initio calculations of the electronic structure and optical absorption response of the black dye sensitizer
in gas phase. We show that, despite the large size of this molecule, the second-order multiconfiguration quasi-degenerate
perturbation theory (MC-QDPT) can be used to calculate vertical excitation energies, oscillator strengths and optical absorption
spectra. The zeroth-order reference states entering perturbation calculations are complete active space (CAS) configuration
interaction (CI) wave functions computed for 12 active electrons distributed in 12 active orbitals. We found that the CI approach
is not enough for taking into account the strong dynamical correlation effects in this system. In fact, the excitation energies
of the CAS-CI target states are strongly renormalized by the MC-QDPT calculations. In the calculated absorption spectra, the
analysis of the perturbed wavefunctions revealed that the stronger absorption bands correspond to metal-to-ligand and ligand-to-ligand
charge transfer processes. Comparison with independent time-dependent extension (TDDFT) calculations performed with different
functionals shows that corrections to the long-range behavior of the functional is pivotal to achieve agreement with the MC-QDPT
results. 相似文献
86.
The cationic bioxazoline Pd(II) complex 2 catalyzes the alternating copolymerization of carbon monoxide with styrene and 4-methylstyrene, respectively, to yield a highly isotactic optically active polymer at room temperature and low carbon monoxide pressure (1–4 atm). 相似文献
87.
S. Nezu S. Walsh V. Meille M. Yoshida J. B. Lando 《Journal of polymer science. Part A, Polymer chemistry》1995,33(6):973-977
The dimer, trimer, and tetramer of 1,11-dodecadiyne, HC?C? (CH2)8? C?CH, were synthesized. The solid-state polymerization of the dimer was investigated by infrared (IR) spectroscopy. IR bands due to the diacetylene moiety were identified through the comparison of the IR spectra of the dimer, trimer, and tetramer. The dimer was found to have two polymorphs, melt-crystallized and solution-crystallized. Both of the polymorphs undergo solid-state polymerization by exposure to γ-ray or UV irradiation. The former has higher polymerizability for the diacetylene moiety than the latter. The solid-state polymerization of the terminal acetylene group was not observed. It is shown that the previously reported dimer structure in which both the diacetylene and terminal acetylene groups are polymerized to form an inherently electrically conducting polymer is incorrect. © 1995 John Wiley & Sons, Inc. 相似文献
88.
Anna Rizzolo Patrizia Lombardi Maristella Vanoli Stefano Polesello 《Journal of separation science》1995,18(5):309-314
Capillary GC/sensory analysis was used to judge if dynamic headspace on sliced pulp and on intact fruit, and solvent extraction could collect the “character impact” and the “contributory” aroma compounds in peaches. Capillary GC/sensory data showed that the headspace techniques selectively recovered the “contributory” volatile compounds, which are strictly related to the characteristic odor of the various peach cultivars, whereas solvent extraction better quantified the “character impact” compounds (lactones). 相似文献
89.
Jos L. Del Valle Cecilia Polo TomS Torroba Stefano Marcaccini 《Journal of heterocyclic chemistry》1995,32(3):899-901
The sodium salt of TOSMIC reacted with (E)-3,4,5,6,7-penta-O-acetyl-1,2-dideoxy-1-C-nitro-D-galacto- (1) and -D-manno-hept-1-enitol (2) to give 3-(D-galacto- (3) and 3-(D-manno-penta-O-acetylpentitol-1-yl)-4-nitropyrrole (4) , respectively. Compound 1 reacted with diaryl nitrile imines, affording 1,3-diaryl-4-(1,2,3,4,5-penta-O-acetyl-D-galacto-pentitol-1-yl)pyrazoles 5 and 6 . 相似文献
90.
Serra S 《Natural product communications》2012,7(4):455-458
The enantioselective synthesis of (S)-1-hydroxy-1,3,5-bisabolatrien-10-one 1 is here described. This sesquiterpene was prepared using (S)-3-(2-methoxy-4-methyl-phenyl)butan-1-ol as a chiral building block. Two different pathways were employed and both turned out to be high yielding, affording 1 in good chemical purity and without any racemization of the existing stereocenter. The spectroscopic data of the synthetic (S)-1 were in very good agreement with those reported for the natural compound, which was extracted from Juniperus formosana heartwood and from the leaves of J. chinensis. The positive sign of the measured optical rotation value of synthetic (S)-1 allows the unambiguous assignment of the absolute configuration of (+)-1 as the (S)-enantiomer. This finding corrects the previous configuration determination which indicated the opposite result. At last, since even (R)-3-(2-methoxy-4-methyl-phenyl)butan-1-ol is preparable in high enantiomer purity by mean of a different biocatalytic process, the formal synthesis of natural (R)-1 was also accomplished. 相似文献