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21.
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B. H. Doreswamy Chandra K. Mantelingu M. A. Sridhar M. Mahendra 《Research on Chemical Intermediates》2014,40(8):2659-2665
The isolation of stable carbenes of the Arduengo and Wanzlick type has prompted us to look for stable nitrenium ions of the related structural type 1-Hydroxy-3-methyl benzotriazolium trifluromethane sulfonate. Nitrenium ions are azocations with structure and survive long enough under in vitro conditions to bind with biological nucleophiles, i.e. DNA bases, and play an important role in carcinogenic processes involving the metabolism of aromatic amines. The title compound (C15H16F3N6O5S) was isolated and crystallized in the monoclinic space group Cc with cell parameters a = 19.866(1) Å, b = 13.128(9) Å, c = 7.673(5) Å, and Z = 4. The structure has both intra- and intermolecular hydrogen bonds. 相似文献
23.
M. A. Sridhar N. K. Lokanath J. Shashidhara Prasad C. V. Yelammagad S. K. Varshney 《Liquid crystals》2013,40(1):45-49
The title compound, cholesteryl 6[4-(4-pentyloxyphenylethynyl)phenoxy]hexanoate (DMT5), a cholesterol-based dimesogen, crystallizes in the monoclinic space group P21 with the parameters a = 9.812(3) Å, b = 9.713(2) Å, c = 24.179(2) Å, β = 92.48(1)° V = 2302.2(9) Å3, Z = 2, F000 = 836, λ(MoKα) = 0.71069 Å, μ = 0.067 cm 1, final R = 0.0772. The structure has intermolecular hydrogen bonds; it is stabilized by the presence of intermolecular contacts whose spacings are less than van der Waals' radii. 相似文献
24.
A. Indrasena Sd. Riyaz Prema L. Mallipeddi P. Padmaja B. Sridhar P.K. Dubey 《Tetrahedron letters》2014
A series of indolylidinepyrazolones were synthesized using a simple, green, and effective route and evaluated as anti-bacterial agents. The compounds were further studied via structure-guided docking study. One of the compounds exhibiting H-bonding interactions with conserved residue Arg144 turned out to be the most potent compound of the series. The minimum inhibitory concentration values ranged from 50 to 25 μg/mL against Staphylococcus aureus in their anti microbial evaluation. 相似文献
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Sridhar Madabhushi Kondal Reddy GodalaRaveendra Jillella Kishore Kumar Reddy MalluNarsaiah Chinthala 《Tetrahedron letters》2014
The synthesis of highly functionalized 2,3-dihydroisoxazoles by a one-pot multicomponent reaction of an aldehyde, hydroxamic acid, and malononitrile or methyl cyanoacetate is described. 相似文献
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B.V. Subba Reddy Govindaraju Karthik Tamilselvan Rajasekaran Aneesh Antony B. Sridhar 《Tetrahedron letters》2012,53(19):2396-2401
A rhodium(II) catalyzed [4+2]/[2+2] cycloaddition reaction of N-protected isatin-3-arylimine with acylketene derived from α-diazocarbonyl compounds has been achieved for the first time for the preparation of a novel class of spiro(oxindolyl)oxazinone and spiro(oxindolyl)-β-lactam derivatives. 相似文献
29.
Devappa S. Lamani Kallam. R. Venugopala Reddy Halehatty. S. Bhojya Naik Halehatty. R. Prakash Naik Ajjanna. M. Sridhar 《高分子科学杂志,A辑:纯化学与应用化学》2013,50(10):857-864
The synthesis of macrocyclic ligand, diquinolineno[1,3,7,9]tetraazacyclododecine-7, 15 (14H, 16H)-dibenzene(L), is described. The metal complexes of the type [MLX2], where (M = Co(II) (1), Cu(II) (2) and X = (Cl), have been synthesized by the reaction of ligand(L) with the corresponding metal salts, and characterized by elemental analysis, FT-IR, 1H-NMR and electronic spectra. The binding property of the complexes with CT-DNA was studied by absorption spectra, viscosity measurements, as well as thermal denaturation studies. The absorption spectral results indicate that the complexes (1) and (2) are binds with base pairs of DNA. The intrinsic binding constant Kb had the value 3.8 × 104M ?1 for (1) and 3.3 × 104 M?1 for (2), respectively, in 5 mM Tris-HCl/50 mM NaCl buffer at pH 7.2. The viscosity measurement results show the viscosity of sonicated rod-like DNA fragments increased when the complex were added to the solution of calf thymus-DNA. The synthesized ligand and its metal complexes have been screened for antibacterial and antifungal activities. 相似文献
30.
Quantitative structure–activity relationship (QSAR) studies were conducted on an in-house database of cytochrome P450 enzyme 1A2 inhibitors using the comparative molecular field analysis (CoMFA), comparative molecular similarity analysis (CoMSIA) and hologram QSAR (HQSAR) approaches. The database consisted of 36 active molecules featuring varied core structures. The model based on the naphthalene substructure alignment incorporating 19 molecules yielded the best model with a CoMFA cross validation value q2 of 0.667 and a Pearson correlation coefficient r2 of 0.976; a CoMSIA q2 value of 0.616 and r2 value of 0.985; and a HQSAR q2 value of 0.652 and r2 value of 0.917. A second model incorporating 34 molecules aligned using the benzene substructure yielded an acceptable CoMFA model with q2 value of 0.5 and r2 value of 0.991. Depending on the core structure of the molecule under consideration, new CYP1A2 inhibitors will be designed based on the results from these models. 相似文献