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Hagiwara M Dohi M Nakahara Y Komatsu K Asahina Y Ueki A Hojo H Nakahara Y Ito Y 《The Journal of organic chemistry》2011,76(13):5229-5239
The biantennary complex-type N-glycans bearing LacNAc and LacdiNAc as the nonreducing end motif were synthesized in a protected form suitable to use in the Fmoc solid-phase peptide synthesis studies. Two approaches for the nonasaccharide synthesis were examined by taking advantage of the highly β-selective glycosylation with GlcNTCA (N-phenyl)trifluoroacetimidate. An earlier approach, which involved the reaction of the trisaccharide donor (Gal-GlcNTCA-Man) and trisaccharide acceptor (Man-GlcNPhth(2)-N(3)), produced a mixture of nonasaccharide isomers. On the other hand, mannosylation of the trisaccharide acceptor (Man-GlcNPhth(2)-N(3)) stereoselectively afforded the known pentasaccharide (Man(3)-GlcNPhth(2)-N(3)), which was reacted with the disaccharyl glycosyl donor (Gal-GlcNTCA or GalNTCA-GlcNTCA) to produce the desired nonasaccharide as a single stereoisomer. Selective dephthaloylation followed by N-acetylation furnished the GlcNAc(2) functionality. The resulting nonasaccharyl azides were condensed with Fmoc-Asp(OPfp)-OBu(t) or Fmoc-Asp(OPfp)-OPac in the presence of Ph(CH(3))(2)P and HOOBt. Finally, the Zn reduction and cleavage of the tert-butyl ester or Zn reduction alone produced the targeted nonasaccharyl Asn building blocks. 相似文献
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Samata E. Shetgaonkar Ritu Mamgain Kotaro Kikushima Toshifumi Dohi Fateh V. Singh 《Molecules (Basel, Switzerland)》2022,27(12)
The chemistry of polyvalent iodine compounds has piqued the interest of researchers due to their role as important and flexible reagents in synthetic organic chemistry, resulting in a broad variety of useful organic molecules. These chemicals have potential uses in various functionalization procedures due to their non-toxic and environmentally friendly properties. As they are also strong electrophiles and potent oxidizing agents, the use of hypervalent iodine reagents in palladium-catalyzed transformations has received a lot of attention in recent years. Extensive research has been conducted on the subject of C—H bond functionalization by Pd catalysis with hypervalent iodine reagents as oxidants. Furthermore, the iodine(III) reagent is now often used as an arylating agent in Pd-catalyzed C—H arylation or Heck-type cross-coupling processes. In this article, the recent advances in palladium-catalyzed oxidative cross-coupling reactions employing hypervalent iodine reagents are reviewed in detail. 相似文献
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Takumi Hamaoka Toyohiko J. Konno Takashi Sawabe Kenji Nishida Kenji Dohi 《哲学杂志》2016,96(24):2518-2536
The effects of Mo on precipitation behaviours in aged cast stainless steels have been investigated. Mo-free CF3 steel and Mo-bearing CF3M steel, both of which consisted of a duplex structure of ferrite and austenite phases, were prepared. Microstructural evolution in the ferrite phase during ageing at 723 K has been observed by transmission electron microscopy (TEM). Precipitates in CF3 steel were identified to belong to the G-phase and possess lattice coherency with the ferrite phase at interphase boundaries. On the other hand, precipitates in CF3M steel were found to be nanodomains of not only to the G-phase but also to another phase enriched in Mo. Some of the nanodomains containing Mo exhibited diffraction patterns having pseudo five-fold symmetry, but others exhibited regular periodicity in high-resolution TEM images. The atomic structure of the Mo-related nanodomains is proposed to be a distorted χ-phase that retains coherency with the matrix. 相似文献
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This paper proposes two types of alternative criteria of optimality for the continuous time portfolio selection problem. The optimality criteria, the so–called Laplace–Stieltjes transform (LST) criteria, are based on the assumption that the financial agent has a target level for the wealth accumulation process. These criteria are closely related to the so–called threshold stopping investment rule. We analytically derive the LST criteria and numerically compare them with the well–known Kelly criterion. It is shown that the portfolio strategies suggested may overcome the problem that the growth portfolio is often overestimated in several investment situations. 相似文献
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M Dohi F Kaiho A Suzuki N Sekiguchi N Nakajima H Nomura Y Kato 《Chemical & pharmaceutical bulletin》1990,38(10):2877-2879
The enhancing effects of myristyl lactate (ML) and lauryl lactate (LL) on the percutaneous absorption of indomethacin (ID) from test solutions in propylene glycol (PG) were investigated in rats. ID absorption was observed to be markedly enhanced by the addition of ML or LL to PG as compared with the control (PG alone). The marked enhancing effects were observed at concentrations greater than 3% ML and 3% LL in PG. In particular, the maximal enhancement of percutaneous absorption of ID was achieved at 5% ML and LL. To elucidate the mode of action of ML as an enhancer, the percutaneous absorption of ID through the skin pretreated with ML alone was investigated. It was suggested that ML acts on the stratum corneum to produce its effect. 相似文献
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Organo‐Iodine(III)‐Catalyzed Oxidative Phenol–Arene and Phenol–Phenol Cross‐Coupling Reaction 下载免费PDF全文
Dr. Koji Morimoto Kazuma Sakamoto Takao Ohshika Dr. Toshifumi Dohi Prof. Dr. Yasuyuki Kita 《Angewandte Chemie (International ed. in English)》2016,55(11):3652-3656
The direct oxidative coupling reaction has been an attractive tool for environmentally benign chemistry. Reported herein is that the hypervalent iodine catalyzed oxidative metal‐free cross‐coupling reaction of phenols can be achieved using Oxone as a terminal oxidant in 1,1,1,3,3,3‐hexafluoropropan‐2‐ol (HFIP). This method features a high efficiency and regioselectivity, as well as functional‐group tolerance under very mild reaction conditions without using metal catalysts. 相似文献
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We have succeeded in the first versatile iodoarene-catalyzed C-C bond-forming reactions by development of a new reoxidation system at low temperatures using stoichiometric bis(trifluoroacetyl) peroxide A in 2,2,2-trifluoroethanol (TFE). The catalytic system supplies a wide range of substrates and functional availabilities sufficient to be used in the key synthetic process of producing biologically important Amaryllidaceae alkaloids. 相似文献