Simultaneous occurrence of energy transfer and photoinduced electron transfer in interactions of hen egg white lysozyme with 4-nitroquinoline-1-oxide

The carcinogenic drug 4-nitroquinoline-1-oxide (4NQO) has been found to bind with the protein hen egg white lysozyme as evident from fluorescence quenching experiments. The binding constant and stoichiometry have been determined. The values of the thermodynamic parameters indicate that the interaction is an enthalpy-driven spontaneous phenomenon. The experimental value of change in free energy is similar to that obtained from the docking study. The far UV circular dichroism spectra show some changes in the secondary structure of protein. The high value of bimolecular quenching constant leads to the possibility of Förster resonance energy transfer (FRET). Along with FRET, the photoinduced electron transfer (PET) from tryptophan residue of protein to 4NQO has also been evident from the transient absorption spectra obtained in laser flash photolysis experiments. The simultaneous occurrence of FRET and PET is the key factor for quenching of intrinsic fluorescence of the protein as it binds with the drug.     

Invariant Measures and the Soliton Resolution Conjecture

The soliton resolution conjecture for the focusing nonlinear Schrödinger equation (NLS) is the vaguely worded claim that a global solution of the NLS, for generic initial data, will eventually resolve into a radiation component that disperses like a linear solution, plus a localized component that behaves like a soliton or multisoliton solution. Considered to be one of the fundamental open problems in the area of nonlinear dispersive equations, this conjecture has eluded a proof or even a precise formulation to date. This paper proves a “statistical version” of this conjecture at mass‐subcritical nonlinearity, in the following sense: The uniform probability distribution on the set of all functions with a given mass and energy, if such a thing existed, would be a natural invariant measure for the NLS flow and would reflect the long‐term behavior for “generic initial data” with that mass and energy. Unfortunately, such a probability measure does not exist. We circumvent this problem by constructing a sequence of discrete measures that, in principle, approximate this fictitious probability distribution as the grid size goes to 0. We then show that a continuum limit of this sequence of probability measures does exist in a certain sense, and in agreement with the soliton resolution conjecture, the limit measure concentrates on the unique ground state soliton. Combining this with results from ergodic theory, we present a tentative formulation and proof of the soliton resolution conjecture in the discrete setting. The above results, following in the footsteps of a program of studying the long‐term behavior of nonlinear dispersive equations through their natural invariant measures initiated by Lebowitz, Rose, and Speer and carried forward by Bourgain, McKean, Tzvetkov, Oh, and others, are proved using a combination of techniques from large deviations, PDEs, harmonic analysis, and bare‐hands probability theory. It is valid in any dimension. © 2014 Wiley Periodicals, Inc.     

Azimuthal correlation and fractal study of compound hadrons (pions and protons) at Dubna and SPS energy

This paper presents an investigation of compound hadrons (pions and protons) distribution emitted from ²⁴Mg-AgBr and ¹²C-AgBr interactions both at 4.5 AGeV and ³²S-AgBr interactions at 200 AGeV. The study includes azimuthal correlations (two particle and three particle), azimuthal asymmetry and fractal behaviour. This paper reveals some interesting results.     

Kinetics and mechanisms of substitution of aqua-ligands in cis-diaqua-bis(bipyridyl)ruthenium(ll) ion by L-cysteine in aqueous medium

Transition Metal Chemistry - The title reaction has been studied spectrophotometrically and a rate-law established within the pH range 5.0 to 6.5, $$ {?...