Copper complexes as chemical nucleases

Redox active mononuclear and binuclear copper(II) complexes have been prepared and structurally characterized. The complexes have planar N-donor heterocyclic bases like 1,10-phenanthroline (phen), dipyridoquinoxaline (dpq) and dipyridophenazine (dppz) ligands that are suitable for intercalation to B-DNA. Complexes studied for nuclease activity have the formulations [Cu(dpq)₂(H₂O)] (ClO₄)₂.H₂O (1), [CuL(H₂O)₂(μ-ox)](ClO₄)₂ (L = bpy,2; phen,3; dpq,4; and dppz,5) and [Cu(L)(salgly)] (L = bpy,6; phen,7; dpq,8; and dppz,9), where salgly is a tridentate Schiff base obtained from the condensation of glycine and salicylaldehyde. The dpq complexes are efficient DNA binding and cleavage active species. The dppz complexes show good binding ability but poor nuclease activity. The cleavage activity of thebis-dpq complex is significantly higher than thebis-phen complex of copper(II). The nuclease activity is found to be dependent on the intercalating nature of the complex and on the redox potential of the copper(II)/copper(I) couple. The ancillary ligand plays a significant role in binding and cleavage activity.     

Singular perturbed problems in the zero mass case: asymptotic behavior of spikes

We discuss the asymptotic behavior of the least energy solution of a Dirichlet problem in the zero mass case. If Q is a uniformly positive potential having k isolated local minima, then we prove the existence of a positive multi-spike solutions having k peaks concentrating at each local minima of the potential.     

Experimental investigation for stability and surface properties of TiO2 and Al2O3 water-based nanofluids

Journal of Thermal Analysis and Calorimetry - Nanofluids have gained recent attention because of their potential applications in diverse engineering fields like enhancing thermal transport,...     

X-ray microprobe of orbital alignment in strong-field ionized atoms

We have developed a synchrotron-based, time-resolved x-ray microprobe to investigate optical strong-field processes at intermediate intensities (10(14) - 10(15) W/cm2). This quantum-state specific probe has enabled the direct observation of orbital alignment in the residual ion produced by strong-field ionization of krypton atoms via resonant, polarized x-ray absorption. We found strong alignment to persist for a period long compared to the spin-orbit coupling time scale (6.2 fs). The observed degree of alignment can be explained by models that incorporate spin-orbit coupling. The methodology is applicable to a wide range of problems.     

MnO2-Mediated Oxidative Cyclization of “Formal” Schiff’s Bases: Easy Access to Diverse Naphthofuro-Annulated Triazines

A different type of MnO₂-induced oxidative cyclization of dihydrotriazines has been developed. These dihydrotriazines are considered as a “formal” Schiff’s base. This method provided easy access to naphthofuro-fused triazine via the C-C/C-O oxidative coupling reaction. The reaction sequence comprised the nucleophilic addition of 2-naphthol or phenol to 1,2,4-triazine, followed by oxidative cyclization. The scope and limitations of this novel coupling reaction have been investigated. Further application of the synthesized compound has been demonstrated by synthesizing carbazole-substituted benzofuro-fused triazines. The scalability of the reaction was demonstrated at a 40 mmol load. The mechanistic study strongly suggests that this reaction proceeds through the formation of an O-coordinated manganese complex.     

Transient film profile of thin liquid film flow on a stretching surface

In this paper we have studied a non-planar thin liquid film flow on a planar stretching surface. The stretching surface is assumed to stretch impulsively from rest and the effect of inertia of the liquid is considered. Equations describing the laminar flow on the stretching surface are solved analytically. It is observed that faster stretching causes quicker thinning of the film on the stretching surface. Velocity distribution in the liquid film and the transient film profile as functions of time are obtained. (Received: May 4, 2004; revised: February 2/August 24, 2005)     

Thin film flow over a non-linear stretching sheet in presence of uniform transverse magnetic field

A thin viscous liquid film flow is developed over a stretching sheet under different non-linear stretching velocities in presence of uniform transverse magnetic field. Evolution equation for the film thickness is derived using long-wave approximation of thin liquid film and is solved numerically by using the Newton–Kantorovich method. It is observed that all types of stretching produces film thinning, but non-monotonic stretching produces faster thinning at small distance from the origin. Effect of the transverse magnetic field is to slow down the film thinning process. Observed flow behavior is explained physically.     

Effect of gamma radiation on growth and survival of common seed-borne fungi in India

The present work describes radiation-induced effects of major seeds like Oryza sativa Cv-2233, Oryza sativa Cv-Shankar, Cicer arietinum Cv-local and seed-borne fungi like Alternaria sp., Aspergillus sp., Trichoderma sp. and Curvularia sp. ⁶⁰Co gamma source at 25 °C emitting gamma ray at 1173 and 1332 keV energy was used for irradiation. Dose of gamma irradiation up to 3 kGy (0.12 kGy/h) was applied for exposing the seed and fungal spores. Significant depletion of the fungal population was noted with irradiation at 1–2 kGy, whereas germinating potential of the treated grain did not alter significantly. However, significant differential radiation response in delayed seed germination, colony formation of the fungal spores and their depletion of growth were noticed in a dose-dependent manner. The depletion of the fungal viability (germination) was noted within the irradiation dose range of 1–2 kGy for Alternaria sp. and Aspergillus sp., while 0.5–1 kGy for Trichoderma sp. and Curvularia sp. However, complete inhibition of all the selected fungi was observed above 2.5 kGy.     

Native silica nanoparticle catalyzed anti-Markovnikov addition of thiols to inactivated alkenes and alkynes: a new route to linear and vinyl thioethers

A new route for the synthesis of linear and vinyl thioethers has been demonstrated using bare silica nanoparticle as catalyst at room temperature under solvent-free conditions. The catalyst can be reused up to six times without loss of catalytic activity.     

Thin-film flow over a nonlinear stretching sheet

A thin viscous liquid film flow is developed over a stretching sheet under different nonlinear stretching velocities. An evolution equation for the film thickness, is derived using long-wave approximation of thin liquid film and is solved numerically by using the Newton–Kantorovich method. A comparison is made with the analytic solution obtained in [B. S. Dandapat, A. Kitamura, B. Santra, “Transient film profile of thin liquid film flow on a stretching surface”, ZAMP, 57, 623-635 (2006)]. It is observed that all types of stretching produce film thinning but non-monotonic stretching produces faster thinning at small distance from the origin. The velocity u along the stretching direction strongly depends on the distance along the stretching direction and the Froude number.