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排序方式: 共有596条查询结果,搜索用时 15 毫秒
41.
42.
Raphaël Grougnet Prokopios Magiatis Sofia Mitaku Alexios‐Leandros Skaltsounis Pierre Cabalion François Tillequin Sylvie Michel 《Helvetica chimica acta》2011,94(4):656-661
Three new dammarane triterpenoids, gardaubryones A–C ( 1 – 3 ), were isolated from the gum collected on the aerial parts of Gardenia aubryi Vieill ., together with the known compounds hydroxydammarenone II ( 4 ), ocotillone ( 5 ), cabraleone, and hollongdione. The structures of the novel compounds were established on the basis of mass spectrometry, NMR experiments, and chemical‐correlation reactions. 相似文献
43.
Vladimir F. Petrov Sofia I. Torgova Ludmila A. Karamysheva Shunsuke Takenaka 《Liquid crystals》1999,26(8):1141-1162
In this review the effect on physico-chemical and electro-optical properties of the introduction of the trans-1,4-cyclohexylene fragment into the molecular core of liquid crystals is discussed, rationalized in terms of existent theories, and compared with the effect of other well-known molecular fragments. 相似文献
44.
Rajamalleswaramma Jogireddy Pierre‐Yves Dakas Gaëlle Valot Sofia Barluenga Nicolas Winssinger 《Chemistry (Weinheim an der Bergstrasse, Germany)》2009,15(43):11498-11506
A library of resorcylic acid lactones (RAL) containing a cis‐enone moiety targeting kinases bearing a cysteine residue within the ATP‐binding pocket was prepared using a fluorous‐mixture synthesis and evaluated against a panel of 19 kinases thus providing important structure–activity trends. Two new analogues were then profiled for their selectivity against a panel of 402 kinases providing the broadest evaluation of this pharmacophores’ selectivity. 相似文献
45.
46.
Pedro Silva Sofia M. Fonseca Cláudia T. Arranja Hugh D. Burrows Ana M. Urbano Abilio J. F. N. Sobral 《Photochemistry and photobiology》2010,86(5):1147-1153
A new 5,10,15,20-tetra-(phenoxy-3-carbonyl-1-amino-naphthyl)-porphyrin was prepared by an isocyanate condensation reaction and its photophysical properties fully evaluated, both in terms of photostability and singlet oxygen production. It shows considerably enhanced photostability when compared with the parent 5,10,15,20-tetra-(3-hydroxy-phenyl)-porphyrin, with the photodegradation quantum yields for T(NAF)PP and T(OH)PP being 4.65 × 10−4 and 5.19 × 10−3, respectively. Its photodynamic effect in human carcinoma HT-29 cells was evaluated. The new porphyrin showed good properties as a sensitizer in photodynamic therapy with an in vitro cytotoxicity IC50 value of 6.80 μg mL−1 for a 24 h incubation. In addition to the potential of this compound, the synthetic route used provides possibilities of extension to a wide range of new sensitizers. 相似文献
47.
Andromahi Tegou Sofia Papadimitriou Georgios Kokkinidis Sotirios Sotiropoulos 《Journal of Solid State Electrochemistry》2010,14(2):175-184
Platinized nickel and cobalt coatings, Pt(Ni) and Pt(Co), have been prepared on glassy carbon, GC, rotating disc electrode
substrates by a two-step room temperature procedure that involved the electrodeposition of nickel and cobalt layers and their
spontaneous partial replacement by platinum (“transmetalation”) when immersed into a chloroplatinic acid solution. By tuning
the quantity of initially deposited nickel and cobalt, Pt(Ni) and Pt(Co) bimetallic coatings having a 26% atom Ni and 30%
atom Co composition have been prepared. For both materials typical Pt surface electrochemistry was recorded during fast voltammetry
in deaerated acid, pointing to the existence of a continuous Pt skin over a Pt–Ni and Pt–Co core. Oxygen reduction at the
Pt(Ni)/GC and Pt(Co)/GC electrodes was studied by means of steady-state voltammetry at a rotating disc electrode and the construction
of Tafel plots from corresponding voltammetric data. It was found that, when the initial potential of the voltammetric sweep
allowed the formation of a complete Pt oxide monolayer, then oxygen reduction was hindered for low overpotentials at Pt(Ni)
and Pt(Co), compared to pure bulk Pt. On the other hand, when the initial potential was less positive (thus leading to the
formation of a fraction of surface oxide monolayer) the presence of Ni and Co enhanced the kinetics of oxygen reduction. The
former behaviour is attributed to a decrease in oxide reduction ability of Pt in the presence of Ni and Co, while the latter
to an increase in dissociative oxygen chemisorption due to Ni and Co. 相似文献
48.
Sofia Georgakakou Michael Kazanis Irene Panderi 《Analytical and bioanalytical chemistry》2010,397(6):2161-2170
A validated method based on liquid chromatography/positive ion electrospray–mass spectrometry (LC-ESI/MS) is described for the quantification of perindopril and its active metabolite, perindoprilat, in human plasma. The assay was based on 500-μL plasma samples, following solid-phase extraction using Oasis HLB cartridges. All analytes and the internal standard (trandolapril) were separated by hydrophilic interaction liquid chromatography using a SeQuant Zic-HILIC analytical column (150.0?×?2.1 mm i.d., particle size 3.5 μm, 200 Å) with isocratic elution. The mobile phase consisted of 10% 5.0 mM ammonium acetate water solution in a binary mixture of acetonitrile/methanol (60:40, v/v) and pumped at a flow rate of 0.10 mL min?1. Quantitation of the analytes was performed with selected ion monitoring (SIM) in positive ionization mode using electrospray ionization interface. The assay was found to be linear in the concentration range of 5.0–500.0 ng mL?1 for perindopril and perindoprilat. Intermediate precision were found less than 3.5% over the tested concentration ranges. A run time of less than 6.0 min for each sample made it possible to analyze a large number of human plasma samples per day. The method is the first reported application of HILIC in the analysis of angiotensin-converting enzyme inhibitors and can be used to quantify perindopril and perindoprilat in human plasma covering a variety of pharmacokinetic or bioequivalence studies. 相似文献
49.
Sofia Quinodoz Michael A. Thomas Jörn Dunkel Eva-Maria Schötz 《Journal of statistical physics》2011,142(6):1324-1336
The trade-off between traits in life-history strategies has been widely studied for sexual and parthenogenetic organisms,
but relatively little is known about the reproduction strategies of asexual animals. Here, we investigate clonal reproduction
in the freshwater planarian Schmidtea mediterranea, an important model organism for regeneration and stem cell research. We find that these flatworms adopt a randomized reproduction
strategy that comprises both asymmetric binary fission and fragmentation (generation of multiple offspring during a reproduction
cycle). Fragmentation in planarians has primarily been regarded as an abnormal behavior in the past; using a large-scale experimental
approach, we now show that about one third of the reproduction events in S. mediterranea are fragmentations, implying that fragmentation is part of their normal reproductive behavior. Our analysis further suggests
that certain characteristic aspects of the reproduction statistics can be explained in terms of a maximum relative entropy
principle. 相似文献
50.