Stathmin interaction with HSC70 family proteins

Stathmin is a ubiquitous cytosolic phosphoprotein participating in the relay and integration of diverse intracellular signaling pathways involved in the control of cell proliferation, differentiation, and activities. It is phosphorylated in response to diverse extracellular signals including hormones and growth factors, and it is highly expressed during development and in diverse tumoral cells and tissues. Stathmin interacts with tubulin and other potential protein partners such as BiP, KIS, CC1 and CC2/tsg101. In our present search for further functional partners of stathmin, we identified proteins in the Hsp70 family, and in particular Hsc70, as interacting with stathmin in vitro. Hsc70 is among the proteins coimmunoprecipitated with stathmin, and it is the main protein retained specifically on stathmin-Sepharose beads identified by one- and two-dimensional electrophoresis and immunoblots. Bovine serum albumin (BSA)-Sepharose did not bind Hsc70, and anti-stathmin antisera specifically inhibited the interaction of Hsc70 with stathmin-Sepharose. The binding of Hsc70 to stathmin is dependent on the phosphorylation status of stathmin, as it did not occur with a "pseudophosphorylated" mutant form of stathmin. This interaction is further dependent on the ATP status of Hsc70. It was inhibited in the presence of ATP-Mg++ but not in the presence of ATP-Mg++ and ethylenediaminetetraacetic acid (EDTA) or of ADP. Our results suggest that the interaction of stathmin with Hsc70 is specific in both proteins and most likely biologically relevant in the context of their functional implication in the control of numerous intracellular signaling and regulatory pathways, and hence of normal cell growth and differentiation.     

Search for supernova relic neutrinos at Super-Kamiokande

A search for the relic neutrinos from all past core-collapse supernovae was conducted using 1496 days of data from the Super-Kamiokande detector. This analysis looked for electron-type antineutrinos that had produced a positron with an energy greater than 18 MeV. In the absence of a signal, 90% C.L. upper limits on the total flux were set for several theoretical models; these limits ranged from 20 to 130 macro nu(e) cm(-2) s(-1). Additionally, an upper bound of 1.2 macro nu(e) cm(-2) s(-1) was set for the supernova relic neutrino flux in the energy region E(nu)>19.3 MeV.     

Bayesian games as stochastic processes

This paper examines stochastic processes generated by sequential games each of whose “states” includes a distribution and whose up-dating rules for state transitions may include Bayes operators. General properties of discrete-time Markov processes are applied to specific games such as iterated matrix games, including Prisoners' Dilemma, and to a new model for the Asch experiments on conflict and conformity.     

Limits on the neutrino magnetic moment using 1496 days of Super-Kamiokande-I solar neutrino data

A search for a nonzero neutrino magnetic moment has been conducted using 1496 live days of solar neutrino data from Super-Kamiokande-I. Specifically, we searched for distortions to the energy spectrum of recoil electrons arising from magnetic scattering due to a nonzero neutrino magnetic moment. In the absence of a clear signal, we found micro(nu)相似文献   

Accessibility and Reliability for Connected Bipartite Graphs

In the recently published atlas of graphs [9] the general listing of graphs with diagrams went up to V=7 vertices but the special listing for connected bipartite graphs carried further up to V=8. In this paper we wish to study the random accessibility of these connected bipartite graphs by means of random walks on the graphs using the degree of the gratis starting point as a weighting factor. The accessibility is then related to the concept of reliability of the graphs with only edge failures. Exact expectation results for accessibility are given for any complete connected bipartite graph N₁ cbp N₂ (where cbp denotes connected bipartite) for several values of J (the number of new vertices searched for). The main conjecture in this paper is that for any complete connected bipartite graph N₁ cbp N₂: if |N₁–N₂| 1, then the graph is both uniformly optimal in reliability and optimal in random accessibility within its family. Numerical results are provided to support the conjecture.     

Incomplete Dirichlet integrals with applications to ordered uniform spacings

Sobel, Uppuluri, and Frankowski, (Selected Tables in Math. Statistics, Vol. IV. Amer. Math. Soc., Providence, R. I., 1977) consider an incomplete Dirichlet integral of type I with several interesting applications connected with the multinomial distribution and provide tables of this integral along with other useful tables. Two incomplete Dirichlet integrals are discussed here along with some useful recurrence relations, providing simple methods of deriving the distribution theory of ordered uniform spacings.     

Mössbauer spectroscopy of 151 europium dicarboxylates

We have previously reported the stability of europium oxalate compared to ammonium europium bis-salen and europium benzoate. We now extend the dicoarboxylic acid chain of the oxalate by introducing additional-CH₂-groups in the dicarboxylate ligands by using malonate, succinate, glutarate and adipate. Additionally, we have examined the effect of alterations in the succinate dianion by introducing functional groups such as [C = C]in the case of the maleide and-OH group in the case of the malide. This study is an attempt to further characterize these compounds. Infrared spectra were used to characterize bridging and chelating dicarboxylates while Mössbauer spectroscopy measurements were used to gain better insight into the structure of heterocyclic “cages” containing two Eu^3?+? ions and two dianions.