全文获取类型
收费全文 | 751篇 |
免费 | 26篇 |
国内免费 | 3篇 |
专业分类
化学 | 513篇 |
晶体学 | 4篇 |
力学 | 25篇 |
数学 | 80篇 |
物理学 | 158篇 |
出版年
2024年 | 1篇 |
2023年 | 8篇 |
2022年 | 21篇 |
2021年 | 22篇 |
2020年 | 25篇 |
2019年 | 17篇 |
2018年 | 12篇 |
2017年 | 12篇 |
2016年 | 36篇 |
2015年 | 27篇 |
2014年 | 36篇 |
2013年 | 45篇 |
2012年 | 43篇 |
2011年 | 52篇 |
2010年 | 15篇 |
2009年 | 42篇 |
2008年 | 36篇 |
2007年 | 48篇 |
2006年 | 32篇 |
2005年 | 27篇 |
2004年 | 26篇 |
2003年 | 14篇 |
2002年 | 20篇 |
2001年 | 24篇 |
2000年 | 18篇 |
1999年 | 17篇 |
1998年 | 7篇 |
1997年 | 10篇 |
1996年 | 9篇 |
1995年 | 9篇 |
1994年 | 8篇 |
1993年 | 7篇 |
1992年 | 4篇 |
1991年 | 4篇 |
1990年 | 3篇 |
1989年 | 3篇 |
1987年 | 3篇 |
1986年 | 3篇 |
1985年 | 1篇 |
1984年 | 3篇 |
1982年 | 4篇 |
1981年 | 3篇 |
1979年 | 2篇 |
1978年 | 9篇 |
1977年 | 2篇 |
1976年 | 2篇 |
1975年 | 5篇 |
1974年 | 1篇 |
1973年 | 2篇 |
排序方式: 共有780条查询结果,搜索用时 46 毫秒
41.
Abner Cardoso Rodrigues Hilda A. Cerdeira Birajara Soares Machado 《The European physical journal. Special topics》2016,225(1):75-82
In this work, we propose changes in the structure of a neuronal network with the intention to provoke strong synchronization to simulate episodes of epileptic seizure. Starting with a network of Izhikevich neurons we slowly increase the number of connections in selected nodes in a controlled way, to produce (or not) hubs. We study how these structures alter the synchronization on the spike firings interval, on individual neurons as well as on mean values, as a function of the concentration of connections for random and non-random (hubs) distribution. We also analyze how the post-ictal signal varies for the different distributions. We conclude that a network with hubs is more appropriate to represent an epileptic state. 相似文献
42.
Carlos Eduardo Barão Leandro Daniel de Paris João Henrique Dantas Matheus Mendonça Pereira Lucio Cardozo Filho Heizir Ferreira de Castro Gisella Maria Zanin Flavio Faria de Moraes Cleide Mara Faria Soares 《Applied biochemistry and biotechnology》2014,172(1):263-274
The use of lipases in industrial processes can result in products with high levels of purity and at the same time reduce pollutant generation and improve both selectivity and yields. In this work, lipase from Thermomyces lanuginosus was immobilized using two different techniques. The first involves the hydrolysis/polycondensation of a silica precursor (tetramethoxysilane (TMOS)) at neutral pH and ambient temperature, and the second one uses tetraethoxysilane (TEOS) as the silica precursor, involving the hydrolysis and polycondensation of the alkoxide in appropriate solvents. After immobilization, the enzymatic preparations were dried using the aerogel and xerogel techniques and then characterized in terms of their hydrolytic activities using a titrimetric method with olive oil and by the formation of 2-phenylethyl acetate in a transesterification reaction. The morphological properties of the materials were characterized using scanning electron microscopy, measurements of the surface area and pore size and volume, thermogravimetric analysis, and exploratory differential calorimetry. The results of the work indicate that the use of different silica precursors (TEOS or TMOS) and different drying techniques (aerogel or xerogel) can significantly affect the properties of the resulting biocatalyst. Drying with supercritical CO2 provided higher enzymatic activities and pore sizes and was therefore preferable to drying, using the xerogel technique. Thermogravimetric analysis and differential scanning calorimetry analyses revealed differences in behavior between the two biocatalyst preparations due to the compounds present. 相似文献
43.
Rosane Bassi Soares Denis Honorato Costa Walter Miyakawa Maria Goretti Temoteo Delgado Aguinaldo Silva Garcez Tania Mateus Yoshimura Martha Simões Ribeiro Silvia Cristina Nunez 《Photochemistry and photobiology》2020,96(3):618-624
Ventilator-associated pneumonia (VAP) is an infection that arises after endotracheal intubation affecting patients under intensive care. The presence of the endotracheal tube (ETT) is a risk factor since it is colonized by multispecies biofilm. Antimicrobial photodynamic therapy (aPDT) could be a strategy to decontaminate ETTs. We verify if methylene blue (MB) associated with external illumination of the ETT could be an alternative to destroy biofilm. We performed an in vitro and ex vivo study. In vitro study was performed with P. aeruginosa biofilm grew over ETT for 7 days. After treatment, the surviving cells were cultured for 3 days and the biofilm was analyzed by crystal violet absorbance. Ex vivo study employed ETT obtained from extubated patients. aPDT was performed with MB (100 µm ) and red LED (λ = 640±20 nm). We quantified the biofilm thickness and used scanning electron microscopy and fluorescence technique to verify morphological and functional changes after aPDT. Our results showed that bacteria remain susceptible to aPDT after sequential treatments. We also attested that aPDT can reduce biofilm thickness, disrupt biofilm attachment from ETT surface and kill microbial cells. These data suggest that aPDT should be investigated to decrease VAP incidence via ETT decontamination. 相似文献
44.
Ana Ediléia Barbosa Pereira Leal Ana Paula de Oliveira Raira Feitosa dos Santos Juliana Mikaelly Dias Soares Erica Martins de Lavor Michelle Cruz Pontes 《Natural product research》2020,34(7):995-1001
AbstractEthanol extracts of different parts of Passiflora cincinnata were obtained by maceration. The total phenolic and flavonoid contents were evaluated. The antioxidant activities were determined by β-carotene-linoleic acid bleaching test, 2,2-diphenyl-1-picrylhydrazil (DPPH), and 2,2’-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical scavenging. The crude ethanol stem extract showed the highest amount of total polyphenols (45.53?mg gallic acid equivalent/g) while the highest total flavonoid contents (1.42?mg of quercetin equivalent/g) were observed in the leaf extract. The lowest IC50 (25.65?μg/ml) by the DPPH method was observed for the stem extract. The ABTS method showed a significant antioxidant activity for all investigated extracts. The secondary metabolite composition of ethanol extracts was assessed by HPLC-DAD-MS/MS analysis, leading to the identification of fourteen secondary metabolites in P. cincinnata extracts. These results showed the potentiality of this species as a source of phenolic compounds and antioxidants. 相似文献
45.
A newly-developed energy-based model for cavitation in rubber particles provides a quantitative basis for understanding the factors controlling toughness in rubber-modified plastics. Cavitation of the rubber is the initial step in the toughening mechanism, and is shown to accelerate yielding of the matrix, either by the formation of dilatation bands or by multiple crazing. Cavitation is thus a strain-softening effect. However, in some cases the cavitated rubber forms fibrils which become highly stretched as local strains increase, and thus begin to carry a significant fraction of the applied stress. The resulting strain-hardening ensures that yielding is not limited to a small deformation zone at a crack tip, but spreads outwards. 相似文献
46.
Thaís Silva da Rocha Alessandro de Lima Jurandy do Nascimento Silva Geni Rodrigues Sampaio Rosana Aparecida Manlio Soares Freitas Renan Danielski Adriano Costa de Camargo Fereidoon Shahidi Elizabeth Aparecida Ferraz da Silva Torres 《Molecules (Basel, Switzerland)》2022,27(3)
Jua (juá in Portuguese) is an underexplored fruit from Brazil’s northeast. This fruit is rich in antioxidant substances. However, there is a dearth of information about jua’s bioactive potential. The present study evaluated two extraction methods (continuous agitation and ultrasound-assisted extraction—UAE) and employed three different solvents (water, ethanol, and acetone) to efficiently recover soluble phenolic compounds. Aqueous extracts obtained by UAE showed the highest total phenolic content (TPC) and antiradical activity. Besides being an eco-friendly procedure, extraction and/or solubility in an aqueous medium is also important for food application. Ellagic acids were the predominant phenolics (80%) found in aqueous jua pulp extract obtained by UAE, as determined by HPLC, while its TPC was 405.8 gallic acid equivalent per gram of fruit. This extract also exhibited a higher scavenging activity towards peroxyl radicals when compared to that of several other fruits from the literature, including grape, strawberry, cranberry, and walnuts, which are known references in terms of antioxidants. This is the first report that demonstrates jua pulp’s potential as an alternative source of ellagic acid and other phenolic acids and flavonoids. Therefore, the outcome of this study provides new information that can be useful for functional food and nutraceutical industries. 相似文献
47.
A generic mathematical model for analyzing the effect of ideal and non-ideal reactor residence time distributions on the size distribution of polymer particles produced with heterogeneous Ziegler-Natta and supported metallocene catalysts was developed. It was shown that the residence time distribution in polymerization reactors can have a significant effect on the size distribution of polymer particles and this can lead to imperfect replication of the catalyst particle size distribution. 相似文献
48.
In this study, a suitable method is reported to produce reinforced antibacterial paper packaging using the antimicrobial triclosan (TC) and organically modified montmorillonite (OMMT) as “model” compounds. Direct incorporation of TC at a concentration of 1 wt% and OMMT at concentrations of 1, 4, 7, and 10 wt% into papers was performed via coating process, and the resulting materials were characterized by in vitro antimicrobial assays, thermogravimetric analysis, scanning electron microscopy, mechanical tests, and water vapor transmission rate determinations. It was demonstrated that the presence of 1% TC in the coated papers exhibited inhibitory effects against Staphylococcus aureus and Escherichia coli. It was also pointed out that increases of approximately 30% in the tensile strength of commercial paper are obtained by using the OMMT at a concentration of 1 wt%. Water barrier property and thermal stability of paper were also enhanced because of the coating process and the incorporation of OMMT. The results from this study demonstrate that OMMT has a great potential to be incorporated into coating formulations to obtain antibacterial‐coated papers with improved properties for various packaging applications. Copyright © 2011 John Wiley & Sons, Ltd. 相似文献
49.
Marie‐Claire Giel Christopher J. Smedley Emily R. R. Mackie Taijie Guo Jiajia Dong Tatiana P. Soares da Costa John E. Moses 《Angewandte Chemie (International ed. in English)》2020,59(3):1181-1186
The boom in growth of 1,4‐disubstituted triazole products, in particular, since the early 2000’s, can be largely attributed to the birth of click chemistry and the discovery of the CuI‐catalyzed azide–alkyne cycloaddition (CuAAC). Yet the synthesis of relatively simple, albeit important, 1‐substituted‐1,2,3‐triazoles has been surprisingly more challenging. Reported here is a straightforward and scalable click‐inspired protocol for the synthesis of 1‐substituted‐1,2,3‐triazoles from organic azides and the bench stable acetylene surrogate ethenesulfonyl fluoride (ESF). The new transformation tolerates a wide selection of substrates and proceeds smoothly under metal‐free conditions to give the products in excellent yield. Under controlled acidic conditions, the 1‐substituted‐1,2,3‐triazole products undergo a Michael addition reaction with a second equivalent of ESF to give the unprecedented 1‐substituted triazolium sulfonyl fluoride salts. 相似文献
50.
M. Peres A. Cruz S. Pereira M.R. Correia M.J. Soares A. Neves M.C. Carmo T. Monteiro A.S. Pereira M.A. Martins T. Trindade E. Alves S.S. Nobre R.A. Sá Ferreira 《Applied Physics A: Materials Science & Processing》2007,88(1):129-133
Synthetic ZnO nanocrystals have been intentionally doped with Eu3+ ions. Structural analysis performed on the nanocrystals showed wurtzite-ZnO as the only phase present in the samples. Photoluminescence
in emission and excitation modes allows the assignment of the intra-4f6 transitions for the Eu3+ ions. From the analysis of the optical data we are able to demonstrate that multiple Eu-related optical centres are present
in the studied samples. Oxygen vacancies are likely candidates to be responsible for the ion accommodation in the ZnO lattice
and from the photoluminescence excitation data we tentatively assign a trap level at ∼200 meV below the conduction band to
this intrinsic defect.
PACS 78.66.Hf; 78.67.-n; 82.80.Yc 相似文献