Iphiona mucronata (Forssk.) Asch. & Schweinf. A Comprehensive Phytochemical Study via UPLC-Q-TOF-MS in the Context of the Embryo- and Cytotoxicity Profiles

Iphiona mucronata (Family Asteraceae) is widely distributed in the Eastern desert of Egypt. It is a promising plant material for phytochemical analysis and pharmacologic studies, and so far, its specific metabolites and biological activity have not yet been thoroughly investigated. Herein, we report on the detailed phytochemical study using UPLC-Q-TOF-MS approach. This analysis allowed the putative annotation of 48 metabolites belonging to various phytochemical classes, including mostly sesquiterpenes, flavonoids, and phenolic acids. Further, zebrafish embryotoxicity has been carried out, where 100 µg/mL extract incubated for 72 h resulted in a slow touch response of the 10 examined larvae, which might be taken as a sign of a disturbed peripheral nervous system. Results of in vitro testing indicate moderate cytotoxicity towards VERO, FaDu, and HeLa cells with CC₅₀ values between 91.6 and 101.7 µg/mL. However, selective antineoplastic activity in RKO cells with CC₅₀ of 54.5 µg/mL was observed. To the best of our knowledge, this is the first comprehensive profile of I. mucronata secondary metabolites that provides chemical-based evidence for its biological effects. A further investigation should be carried out to precisely define the underlying mechanisms of toxicity.     

On formations like ℸℏ

Gomel. Translated fromSibirskiî Matematicheskiî Zhurnal, Vol. 34, No. 5, pp.181–187, September–October, 1993.     

On the structure and growth rate of unstable modes to the Rossby‐Haurwitz wave

The normal mode instability study of a steady Rossby‐Haurwitz wave is considered both theoretically and numerically. This wave is exact solution of the nonlinear barotropic vorticity equation describing the dynamics of an ideal fluid on a rotating sphere, as well as the large‐scale barotropic dynamics of the atmosphere. In this connection, the stability of the Rossby‐Haurwitz wave is of considerable mathematical and meteorological interest. The structure of the spectrum of the linearized operator in case of an ideal fluid is studied. A conservation law for perturbations to the Rossby‐Haurwitz wave is obtained and used to get a necessary condition for its exponential instability. The maximum growth rate of unstable modes is estimated. The orthogonality of the amplitude of a non‐neutral or non‐stationary mode to the Rossby‐Haurwitz wave is shown in two different inner products. The analytical results obtained are used to test and discuss the accuracy of a numerical spectral method used for the normal mode stability study of arbitrary flow on a sphere. The comparison of the numerical and theoretical results shows that the numerical instability study method works well in case of such smooth solutions as the zonal flows and Rossby‐Haurwitz waves. © 2004 Wiley Periodicals, Inc. Numer Methods Partial Differential Eq, 2005     

The Structure of Finite Non-Nilpotent Groups in Which Every 2-Maximal Subgroup Permutes with all 3-Maximal Subgroups

The structure of finite non-nilpotent groups in which every 2-maximal subgroup permutes with every 3-maximal subgroup is described.     

On sufficient conditions for global asymptotic stability of the barotropic fluid on a sphere

Summary Sufficient conditions are obtained for the global asymptotic stability of solutions to the vorticity equation for a forced barotropic viscous fluid on a rotating sphere. The Sundstr?m's requirements to the smoothness of the basic solution are weakened here, which makes it possible to apply these conditions to a wider class of the solutions, for example, modons, having continuous derivatives up to the second order only. The author of this paper has agreed to not receive the proofs for correction.     

Computing the aircraft aerodynamic coefficients in the presence of physicochemical reactions

The aerodynamic equivalence method, previously developed on the basis of the method of lines and the grid method for numerical integration of the equations of gas dynamics around smooth bodies, is generalized in application to aircraft with an arbitrary cross section in the presence of equilibrium physicochemical reactions. Numerical results for traditional aerodynamic blunt cone shapes are presented for various Mach numbers, angles of attack, and flight altitudes. Different methods are compared by accuracy, simplicity of algorithms, and speed of their computer implementation. The effectiveness of the method is demonstrated in application to the aerodynamic characteristics of bodies with a square cross section.Translated from Vychislitel'naya i Prikladnaya Matematika, No. 59, pp. 43–51, 1986.