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71.
The acoustic structure of diplophonia was investigated spectrographically and in terms of perturbation measures, while the perception of diplophonia among other voice qualities was confirmed auditorily by trained listeners. Recordings of pathological voices were presented to listeners for systematic evaluation, and narrowband spectrography was used to quantify the subharmonics within each sample. Subharmonics strongly correlated with the perception of diplophonia, but occurrence was mostly intermittent, and structure was highly variable between samples. Uniquely among voice qualities identified perceptually, diplophonia was found to correlate positively with the number of subharmonics (irrespective of percentage of occurrence) and with perturbation parameters measured separately. Exceptions to these group results indicated that diplophonia was perceived sometimes in the absence of subharmonic structure, and subharmonic structure was observed without a commensurate perception of diplophonia. In light of these data, a less deterministic relation between diplophonia and subharmonic structure is proposed. 相似文献
72.
E. Cavalli E. Zannoni A. Belletti V. Carozzo A. Toncelli M. Tonelli M. Bettinelli 《Applied physics. B, Lasers and optics》1999,68(4):677-681
3 Sc2Ge3O12 (CaSGG) single crystals with the garnet structure have been grown by means of the flux growth technique. The doping with
Nd3+ and Mg2+ (as charge compensator) yields samples suitable for optical spectroscopy experiments. The absorption and emission properties
have been measured at temperatures ranging from 10 to 298 K. The emission spectra give evidence of the presence of non-equivalent
Nd3+ sites. The decay time of the 1.06-μm emission band has been measured as a function of temperature and incident power. The
intensities of the 298 K absorption transitions have been analyzed by means of the Judd–Ofelt theory. The radiative lifetimes,
the branching ratios (β), and the spontaneous emission probabilities have been evaluated for the 4F3/2 excited state using the calculated intensity parameters. The stimulated-emission cross sections and the branching ratios
have been estimated from the experimental data for the most important laser transitions indicating that this crystal can be
considered an interesting material for solid-state laser applications.
Received: 2 June 1998 / Revised version: 28 October 1998 / Published online: 24 February 1999 相似文献
73.
74.
Jacopo Sgrignani Claudia Bonaccini Giovanni Grazioso Matteo Chioccioli Andrea Cavalli Paola Gratteri 《Journal of computational chemistry》2009,30(15):2443-2454
A combined quantum mechanical (QM)‐polarized docking and molecular dynamics approach to study the binding mode and to predict the binding affinity of ligands acting at the α4β2‐nAChR is presented. The results obtained in this study indicate that the quantum mechanical/molecular mechanics docking protocol well describes the charge‐driven interactions occurring in the binding of nicotinic agonists, and it is able to represent the polarization effects on the ligand exerted by the surrounding atoms of the receptor at the binding site. This makes it possible to properly score agonists of α4β2‐nAChR and to reproduce the experimental binding affinity data with good accuracy, within a mean error of 2.2 kcal/mol. Moreover, applying the QM‐polarized docking to an ensemble of nAChR conformations obtained from MD simulations enabled us to accurately capture nAChR‐ligand induced‐fit effects. © 2009 Wiley Periodicals, Inc. J Comput Chem, 2009 相似文献
75.
Rachele Stefania Dr. Lorenzo Tei Dr. Alessandro Barge Dr. Simonetta Geninatti Crich Dr. Ibolya Szabo Dr. Claudia Cabella Dr. Giancarlo Cravotto Prof. Silvio Aime Prof. 《Chemistry (Weinheim an der Bergstrasse, Germany)》2009,15(1):76-85
Three new magnetic resonance imaging probes that target glutamine transporters have been synthesized. They consist of a Gd‐DOTA‐monoamide moiety (DOTA=1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraacetic acid) linked through a six carbon atom chain to a vector represented by a glutamine residue bound through α‐carboxylic, γ‐carboxamidic, or α‐amino functionalities. Their uptake by HTC (rat hepatocarcinoma) and healthy rat hepatocytes has shown that the system containing the glutamine vector bound through the α‐carboxylic group displays a markedly higher affinity for tumor cells. The observed behavior is rationalized in terms of the exploitation of an additional glutamine transporter active in hepatic tumor cells. 相似文献
76.
Barbara Chiavarino Dr. Maria Elisa Crestoni Prof. Simonetta Fornarini Prof. Francesco Lanucara Dr. Joel Lemaire Dr. Philippe Maître Prof. Debora Scuderi Dr. 《Chemistry (Weinheim an der Bergstrasse, Germany)》2009,15(33):8185-8195
Anion–π interactions between a π‐acidic aromatic system and an anion are gaining increasing recognition in chemistry and biology. Herein, the binding features of an electron‐deficient aromatic system (1,3,5‐trinitrobenzene (TNB)) and selected anions (OH?, Br?, and I?) are examined in the gas phase by using the combined information derived from collision‐induced dissociation experiments at variable energy, infrared multiple‐photon dissociation spectroscopy, and quantum chemical calculations. We provide spectroscopic evidence for two different structural motifs of anion–arene complexes depending on the nature of the anion. The TNB–OR? complexes (R=H, or alkyl groups which were studied earlier) adopt an anionic σ‐complex structure whereby RO? attacks the aromatic ring with covalent bond formation, and develops a tetrahedral ring carbon bound to H and OR. The halide complexes rather conform to a structure in which the TNB moiety is hardly altered, and the halogen is placed on an unsubstituted carbon atom over the periphery of the ring at a C–X distance that is appreciably longer than a typical covalent bond length. The ensuing structural motif, previously characterized in the solid state and named weak σ interaction, is now confirmed by an IR spectroscopic assay in the gas phase, in which the sampled species are unperturbed by crystal packing or solvation effects. 相似文献
77.
Cavalli A Masetti M Recanatini M Prandi C Guarna A Occhiato EG 《Chemistry (Weinheim an der Bergstrasse, Germany)》2006,12(10):2836-2845
Density functional theory (DFT) has been used to define the energy profiles of the Nazarov reaction involving cyclic systems. The calculations were carried out at the B3LYP/6-311G** level of theory and the solvent (dichloromethane) contribution was estimated by using the recently developed SM5.43R solvation model. DFT calculations were first carried out to determine the energy profiles associated with the electrocyclization reactions of 3-hydroxy- and 3-ethoxypentadienyl cations in which one of the double bonds is embedded in O-heterocyclic and carbocyclic systems. In particular, the effects on the reaction rate of modifications to the substrate, as well as the presence of the heteroatom in the cycle, have been investigated. The torquoselectivity of the electrocyclization reaction was then explored with substituted O-heterocycles to understand the factors that control the stereochemical outcome of the process that preferentially provides 2,5-trans-disubstituted products. These DFT-based results rationally explain most of the experimental observations related to the Nazarov reaction of the substrates herein investigated and could be useful in the rational interpretation, and likely in the prediction, of the outcome of Nazarov reactions involving other cyclic systems. 相似文献
78.
Determination of nitrite, nitrate, and glucose-6-phosphate in muscle tissues and cured meat by IC/MS
The endogenous nitrate concentration in fresh meat and the residual nitrate and nitrite contents after curing are related to food quality and safety. Most ion chromatography (IC) methods suffer from interferences, especially in fresh meat samples, in which the endogenous nitrate content is low, and in cured meat products, in which other nitrogenous compounds can interfere with the separation of inorganic anions. One of the major classes of interfering compounds in fresh meat are sugar phosphates, which originate from glycolysis during the conversion of muscle glycogen to lactic acid. Nitrate can be separated from interfering compounds with a high-capacity anion-exchange column that was manufactured for use with hydroxide eluents (i.e., hydroxide-selective). This column has a different selectivity than traditional IC columns that use carbonate eluents and facilitates the determination of nitrate in both fresh and cured meats. Nitrate was detected by both suppressed conductivity measurement and mass spectrometry (MS). The identifications of nitrate and glucose-6-phosphate were confirmed by MS detection. The described IC/MS method is robust, sensitive to nitrate concentrations as low as 0.10 mg/kg, and can determine sugar phosphates that are useful for monitoring meat freshness. We successfully used this method to determine nitrate in nearly 100 muscle tissues and cured meat samples. 相似文献
79.
Colombo F Benaglia M Orlandi S Usuelli F Celentano G 《The Journal of organic chemistry》2006,71(5):2064-2070
The stereoselective addition of aryl- and alkylacetylene derivatives to imines was studied. The reaction is catalyzed by copper complexes of enantiomerically pure bisimines, readily prepared in very high yields from the commercially available binaphthyl diamine. A very simple experimental procedure allowed to obtain at room temperature optically active propargylamines in high yields and enantioselectivity. Interestingly, bisimine/copper(I) complexes were able to promote the direct, enantioselective, catalytic addition to imines of alkylacetylenes. The effects of catalyst loading and other reaction parameters on the stereochemical outcome of the transformation were investigated. The extremely convenient methodology, the mild reaction conditions, and the possibility of a modular approach for developing new and more efficient bisimine-based chiral ligands make the present methodology very attractive. 相似文献
80.
Hyperthermia (HT) is a therapeutic strategy based on the selective damaging of tumoral cells when heated at temperatures in the range 41-45 degrees C. We are currently investigating the feasibility of Ultrasound (US) imaging to perform a non-invasive, efficient and cost effective temperature monitoring of heated tissues. Commercial US contrast agents (Sonovue, Bracco), consisting in microbubbles of SF(6) coated with a phospholipidic shell, greatly improve the US echo signal from tissues. Further investigations have been performed, consisting in physico-chemical and US-imaging characterization. In conclusion, we demonstrate that Sonovue microbubbles reach their maximal diameter at 40 degrees C, and then a sharp decrease is observed, possible due to the occurrence of gel-sol transition of the phospholipidic shell. At the same temperature the maximal backscattering intensity is predicted and actually experimentally observed. Sonovue, as well as other contrast agents based only on phospholipids, are, therefore, not suitable for use as non-invasive temperature monitoring medium since it is sensitive to temperatures below the hyperthermic range. Although microbubbles are in principle thermally effective, other coating materials should be investigated in order to increase their operative thermal range. 相似文献