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861.
Stuti Bhagat Simona Tyagi Sanjay Singh 《Particle & Particle Systems Characterization》2023,40(11):2300079
The therapeutic success of nanomedicines requires nanomaterials to either adhere to the surface or internalize within the cytoplasm. The endocytosis phenomenon is controlled by the nanomaterial's shape, size, composition, charge, and capping molecules. The membrane potential-based non-specific internalization of therapeutic nanomedicines offers limited benefits than receptor-based specific delivery. Glut receptor-based internalization of glucose molecules is a well-known process in cancerous cells, which is one of the most exploited strategies to target cancer cells using nanoparticles. However, the internalization process of other structurally similar monosaccharides (D-Galactose, Mannose, and D-Fructose) conjugated nanoparticles remains to be unexplored. Herein, D-Glucose, D-Galactose, Mannose, and D-Fructose-coated AuNPs and AgNPs have been synthesized and studied the role of Glut receptors in their internalization in liver cancer cells, and compared them with non-cancerous cells. Results revealed that almost all monosaccharide-coated NPs exhibited high uptake in liver cancer cells than non-cancerous cells. Glut-1 receptor is observed to play a key role in the uptake and inhibition of Glut-1 receptors by genistein lead to a significant decrease in nanoparticle uptake. In conclusion, monosaccharide-conjugated nanoparticles can be used to direct the selective internalization of AuNPs and AgNPs in hepatic cancer cells to realize therapeutic and imaging applications. 相似文献
862.
Esther Amevor Simona Bronco Giambattista Consiglio Silvia Di Benedetto 《Macromolecular Symposia》1995,89(1):443-454
Strictly alternating copolymers between olefins and carbon monoxide are synthesized using cationic palladium catalysts modified by phosphorus or nitrogen ligands. Basic chelate diphosphines as the ligand allow the regioregular copolymerization of aliphatic olefins thus affording, e.g. in the case of propene, poly(1-oxo-2-methyltrimethylene). Steric control of the copolymerization process towards the production of overwhelmingly isotactic copolymers is possible particularly when using atropisomeric ligands. In the case of styrene as the substrate and for all ligands employed the copolymerization process is regioregular. Prevailing syndiotactic structure is obtained with 1,10-phenanthroline or 2,2′-bipyridine as the ligand. Chelate thioether ligands allow the preparation of a completely atactic material. For 4-tert-butylstyrene an isotactic structure became accessible by using chiral bisoxazolidines. The prevailing structure of the copolymers of cyclopentene corresponds to a 1,3-enchainment of the olefin units most probably associated with a prevailing diisotactic structure 相似文献
863.
864.
Preparation and characterization of some nonstoichiometric interpolyelectrolyte complexes (NIPECs) as stable colloidal dispersions by the interaction between poly(sodium 2-acrylamido-2-methylpropanesulfonate) (NaPAMPS) and three strong polycations bearing quaternary ammonium salt centres in the backbone, poly(diallyldimethylammonium chloride) (PDADMAC) and two polycations containing N,N-dimethyl-2-hydroxypropyleneammonium chloride units (PCA5 and PCA5D1), have been followed in this study as a function of the polycation structure and polyelectrolyte concentration. Complex characteristics were followed by polyelectrolyte titration, turbidity and quasi-ellastic light scattering. Almost monodisperse NIPECs nanoparticles with a good storage stability were prepared when total concentration of polyelectrolyte was varied in the range 0.85-6.35 mmol/L, at a ratio between charges (n−/n+) of 0.7. NIPECs as a new kind of flocculants were used to flocculate a stable monodisperse silica suspension. The main advantage of NIPECs as flocculants is the broad flocculation window, which is a very important aspect for industrial applications. 相似文献
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866.