Investigation of groundwater flow with the aid of indium—EDTA-complex using neutron activation for the determination of the tracer

Indium-EDTA-tracer detected in water samples by neutron activation analysis was used in a multitracer karst experiment carried out in the catchment area of Ljubljanica springs (Yugoslavia) in 1975. For this purpose it was tried, to develop the detection procedure in such a manner, that the samples could be processed with reduced labour demand and reduced interferences by water ingredients. This was attained by liberating the indium from the EDTA-complex and subsequent coprecipitation on bismuth-hydroxide which yields no interfering γ-emitters under irradiation with reactor neutrons. Flow parameters in the Ljubljanica karst system were measured and are presented.     

Liposome delivered and polymeric metal complexes as potential sensitizers for the photodynamic therapy of cancer

Different possibilities of macromolecular metal complexes as photosensitizers (PS) for their potential use in the photodynamic therapy of cancer are described. The prepared metal porphyrazin derivatives (metals: Zn(II), Si(IV)(X)₂) exhibit long wavelength absorption and high singlet oxygen quantum yields under irradiation. One possibility is the incorporation of the PSs in liposomal vesicles giving hydrophobic conjugates with low densitiy proteins in the serum after injection. Good tumor accumulation and photodynamic activities are observed. Increased tumor uptake is also known for Pcs covalently connected via the ligand to poly(ethylene glycol monomethyl ether). New compounds contain the hydrophilic polymer at axial substituents of Si(X)₂Pc and Si(X)₂Nc. Some newly synthesized compounds with only one functional group exhibit the possibility of coupling to macromolecules like e.g. monoclonal antibodies.