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81.
A series of new enantiomerically pure and racemic 1,3-dioxolanes 1-8 was synthesized in good yields and short reaction times by the reaction of salicylaldehyde with commercially available diols using a catalytic amount of Mont K10. Elemental analysis and spectroscopic characterization established the structure of all the newly synthesized compounds. These compounds were tested for their possible antibacterial and antifungal activity. Biological screening showed that all the tested compounds, except 1, show excellent antifungal activity against C. albicans, while most of the compounds have also shown significant antibacterial activity against S. aureus, S. epidermidis, E. faecalis and P. aeruginosa. 相似文献
82.
A comprehensive library of N- or 1-substituted indoles was formed by conjugate additions of indoline with Michael acceptors followed by an oxidation step. Using N-substituted indoles as key Michael donors, the synthesis of 1,3-disubstituted indoles was also accomplished. 相似文献
83.
Ozug J Wudyka S Gunay NS Beccati D Lansing J Wang J Capila I Shriver Z Kaundinya GV 《Analytical and bioanalytical chemistry》2012,403(9):2733-2744
Low-molecular-weight heparins (LMWHs) are produced from heparin by various depolymerization strategies, which result in a reduction of the average molecular weight of the polysaccharide chains, a reduction of the anti-factor IIa activity (and a concomitant increase in the anti-factor Xa/anti-factor IIa ratio), and introduction of process-related structural signatures. Numerous techniques have been developed to characterize LMWHs and to measure the type and extent of structural modifications that are introduced as a function of the depolymerization process. We present here an analysis of the tetrasaccharide pool of enoxaparin sodium, a LMWH produced by chemical β-elimination of heparin benzyl ester. We identify the predominant sequences present within the tetrasaccharide pool and demonstrate that this pool provides a sensitive, specific readout of the physicochemical process conditions used to generate enoxaparin sodium. 相似文献
84.
Eda Yücel Fikri Karaesmen F. Sibel Salman Metin Türkay 《European Journal of Operational Research》2009,199(3):759-768
The problem of product assortment and inventory planning under customer-driven demand substitution is analyzed and a mathematical model for this problem is provided in this paper. Realistic issues in a retail context such as supplier selection, shelf space constraints, and poor quality procurement are also taken into account. The performance of three modified models, one that neglects customers’ substitution behavior, another that excludes supplier selection decision, and one that ignores shelf space limitations, are analyzed separately with computational experiments. The results of the analysis demonstrate that neglecting customer-driven substitution or excluding supplier selection or ignoring shelf space limitations may lead to significantly inefficient assortments. The effects of demand variability and substitution cost on optimal assortment and supplier selection decisions as well as on the optimal revenue are also investigated. The main contribution of this paper is the development of a practical and flexible model to aid retailers in finding optimal assortments to maximize the expected profit. 相似文献
85.
Sibel Morkoç Karadeniz Tuba Klnç Burcu Bozkurt rak Tuba Irmak Sakaolu ar rak Mehmet Erturul Ali Ercan Ekinci 《光谱学与光谱分析》2016,36(6):1998-2000
In this Study, Cadmium Oxide (CdO) nanostructures were synthesized by using Chemical Bath Deposition Technique. The synthesized process was carried out at room temperature. The structural and optical properties of nanostructures was characterized by XRD, SEM and UV-Vis techniques. As a result, the CdO nanostructures are oriented along (111) plane of cubic crystal structure. The morphology of CdO nanostructures showed interconnected prism-like and cauliflower-type cluster nanostructure. The UV results of this structures with high absorbtion coefficient are observed to be in accordance with the CdO nanoparticles. 相似文献
86.
Sibel Şahin 《Complex Analysis and Operator Theory》2016,10(2):295-309
We study Poletsky–Stessin Hardy spaces on complex ellipsoids in \(\mathbb {C}^{n}\). Different from one variable case, classical Hardy spaces are strictly contained in Poletsky–Stessin Hardy spaces on complex ellipsoids so boundary values are not automatically obtained in this case. We have showed that functions belonging to Poletsky–Stessin Hardy spaces have boundary values and they can be approached through admissible approach regions in the complex ellipsoid case. Moreover, we have obtained that polynomials are dense in these spaces. We also considered the composition operators acting on Poletsky–Stessin Hardy spaces on complex ellipsoids and gave conditions for their boundedness and compactness. 相似文献
87.
Synthesis of Some Novel Norbornene‐Fused Pyridazines as Potent Inhibitors of Carbonic Anhydrase and Acetylcholinesterase 下载免费PDF全文
Ramazan Kocak Esra Turan Akın Pınar Kalın Oktay Talaz Nurullah Saracoglu Arif Dastan Ilhami Gülcin Serdar Durdagi 《Journal of heterocyclic chemistry》2016,53(6):2049-2056
The reaction of benzocyclic norbornene derivatives with tetrazines provided the 1,3‐dihydropyridazine derivatives as a single product. The dihydropyridazine derivatives have been dehydrogenated with phenyliodine bis(trifluoroacetate) to yield the corresponding pyridazines in a high yield. Two stable diazines, primary product of corresponding 1,4‐dihydropyridazine, were also isolated. Structures were then determined by 1H‐NMR, and 13C‐NMR beside to elemental analyses. The novel pyridazine derivatives ( 8 , 9 ) efficiently inhibited the cytosolic human carbonic anhydrase isoenzymes I and II (hCA I and II). In addition, these novel pyridazine derivatives ( 8 , 9 ) were evaluated for their in vitro acetylcholinesterase inhibitory activity. Ligand–receptor interactions are tested using molecular docking simulations. Obtained docking scores are in good agreement with in vitro results. 相似文献
88.
89.
Voltammetric and liquid chromatographic (LC) methods have been developed for the simultaneous determination of amlodipine besylate (AML) and rosuvastatin calcium (ROS) for the first time. Detailed electrochemical behavior and simultaneous voltammetric determination of AML and ROS were investigated in detail using glassy carbon electrode (GCE). High-performance liquid chromatography (HPLC) and ultra-performance liquid chromatography (UPLC) were also developed for the comparison. Voltammetric method exhibited linear dynamic responses for the simultaneous assay of AML and ROS in the concentration range between 0.006 and 2.85 μg/mL and between 0.01 and 5.00 μg/mL, with detection limits of 0.001 and 0.003 μg/mL, respectively. On the other hand, LC methods presented a wider linearity range than that of the SWV method between 0.5 and 100 μg/mL with the detection limits of 0.011 and 0.027 μg/mL for AML and 0.034 and 0.042 μg/mL for ROS by UPLC and HPLC techniques, respectively. 相似文献
90.
Determination of chromatographic dissociation constants of some carbapenem group antibiotics and quantification of these compounds in human urine 下载免费PDF全文
Ebru Çubuk Demiralay Duygu Koç Y. Doğan Daldal Güleren Alsancak Sibel A. Ozkan 《Biomedical chromatography : BMC》2014,28(5):660-666
The dissociation constant values (sspKa) of some carbapenem group drugs (ertapenem, meropenem, doripenem) in different percentages of methanol–water binary mixtures (18, 20 and 22%, v/v) were determined from the mobile phase pH dependence of their retention factor. Evaluation of these data was performed using the NLREG program. From calculated pKa values, the aqueous pKa values of these subtances were calculated by different approaches. Moreover, the correlation established between retention factor and the pH of the water–methanol mobile phase was used to determine the optimum separation conditions. In order to validate the optimized conditions, these drugs were studied in human urine. The chromatographic separation was realized using a Gemini NX C18 column (250 × 4.6 mm i.d., 5 µm particles) and UV detector set at 220 and 295 nm. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献