A quantitative structure-activity relationship study of antifungal analogues of 3,4-substituted 5-((1H-1, 2, 4-triazol-1-yl)methyl)-4H-1,2,4-triazole

A series of 5-((1H-1, 2, 4-triazol-1-yl)methyl)-4H-1,2,4-triazole derivatives were prepared and evaluated for their antifungal activities. Quantitative structure–activity relationship studies were performed on these compounds using physicochemical parameters as independent parameters and antifungal activity as a dependent parameter, where antifungal activity correlated best (correlation coefficient r > 0.8) with physicochemical parameters (Hammett’s constants σ _p , F) and van der Waals volume V ₁. Results are interpreted on the basis of multiple regression and cross-validation methodology. Furthermore, the domain of applicability which indicates the area of reliable predictions is defined. Electronic supplementary material  The online version of this article (doi:) contains supplementary material, which is available to authorized users. Chemical structures of A1–26 and A39; synthetic procedures; synthesis schemes; mps, yields, ¹H NMR; elemental analyses of compounds and single crystal X-ray diffraction of compounds.     

New double Wronskian solutions of the AKNS equation

Soliton solutions, rational solutions, Matveev solutions, complexitons and interaction solutions of the AKNS equation are derived through a matrix method for constructing double Wronskian entries. The latter three solutions are novel. Moreover, rational solutions of the nonlinear Schrodinger equation are obtained by reduction.     

A DR-WFOI fusion system for the real-time molecular imaging in vivo

Digital radiography (DR) and whole-body fluorescent optical imaging (WFOI) have been widely applied in the field of molecular imaging, with the advantages in tissues and functional imaging. The integration of them contributes to the development and discovery of medicine. We introduce an equipment, performance of which is better than that of another molecular imaging system manufactured by Kodak Corp. It can take real-time small animal imaging in vivo, with lower cost and shorter development cycle on the LabVIEW platform. At last, a paradigm experiment on a nude mouse with green fluorescent protein (GFP) transgenic tumor is given to present a real-time DR-WFOI fusion simultaneous image.     

Intracavity frequency-doubled green vertical external cavity surface emitting laser

An intracavity frequency-doubled vertical external cavity surface emitting laser (VECSEL) with green light is demonstrated. The fundamental frequency laser cavity consists of a distributed Bragg reflector (DBR) of the gain chip and an external mirror. A 12-mW frequency-doubled output has been reached at 540 nm with a nonlinear crystal LBO when the fundamental frequency output is 44 mW at 1080 nm. The frequency doubling efficiency is about 30%.     

汽轮机调节阀内流动特性的试验研究

介绍了最常用的G-I型调节阀内的动态压力测量方法及其各关键部位的流动特性,尤其是引起不稳定流动的主要因素即气流的压力脉动特性。测试结果表明,调节阀处于不稳定工作状态即阀杆振动工况取决于脉动压力与阀杆固频率是否同频,并非其脉动压力值大小;调整阀杆固有频率是消除调节阀振动最简便和有效的方法。     

Solid-phase synthesis of "mixed" peptidomimetics using Fmoc-protected aza-beta3-amino acids and alpha-amino acids

[structure: see text] A solid-phase fluorenylmethyloxycarbonyl (Fmoc)-based synthesis strategy is described for "mixed" aza-beta3-peptides as well as a convenient general approach for their required building blocks, the aza-beta3-amino acid residues (aza-beta3-aa). These monomers allow the synthesis of relatively large quantities of pure mixed aza-beta3-peptides. The required Fmoc-substituted aza-beta3-amino acids are accessible by convenient synthesis, and a number of monomers including those containing side chains with functional groups have been synthesized. The method was applied toward the solid-phase synthesis of aza-beta3-peptide mimetics of a biologically active histone H4 sequence.     

The Ru(II)-supported heptatungstates [HXW7O28Ru(dmso)3]6-(X=P, As)

The ruthenium(II)-supported heteropolyanions [HXW7O28Ru(dmso)3]6-(X=P, 1; As, 2) are composed of a Ru(dmso)3 group attached to an unprecedented heptatungstate fragment via two Ru-O-W bonds and one Ru-O-X bond, which represents a fundamentally novel mode of Ru-coordination to a polyoxoanion framework. Multinuclear 183W, 31P, 13C, and 1H NMR studies indicate high stability of 1 and 2 in solution.