Hydrogen Effect on Coke Removal and Catalytic Performance in Pre-Carburization and Methane Dehydro-Aromatization Reaction on Mo/HZSM-5

1. Introduction As an effective utilization of methane, the methane dehydro-aromatization was focused in the last decade [1-28]. Over the Mo/HZSM-5 bi- functional catalyst at high reaction temperature, methane can be converted into light aromatics (ben- zene and naphthalene) and hydrogen. Mo active species can activate the C—H bond of methane; and HZSM-5 supplies the acid sites for the oligomeriza- tion and cyclization of hydrocarbons to form aromat- ics, and suppresses the deeper condens…     

Design of peptide–dendrimer conjugates with tumor homing and antitumor effects

Development of drug delivery systems for cancer therapy is a crucial issue. Previously, some peptides were designed as tumor homing cell-penetrating peptides with antitumor activities. In this study, dual function dendrimers with tumor targeting activities and antitumor effects were designed using the tumor targeting CPP44 peptide for acute myelogenous leukemia (AML) and the antitumor p16^INK4a peptide. Two types of peptide–dendrimer conjugates were synthesized. One was a CPP44-linked p16^INK4a peptide-conjugated dendrimer (tandem linked dendrimer) and the other was a dendrimer conjugated with separate CPP44 and p16^INK4a peptides (parallel linked dendrimer). In addition, a peptide cathepsin B substrate was linked to the antitumor p16^INK4a peptide to release it from the carriers. These peptide–dendrimer conjugates produced more effective antitumor effects than a CPP44-linked p16^INK4a peptide. The parallel linked dendrimer showed less association with AML cells than the tandem linked dendrimer, but had greater antitumor effects. This suggested that both cellular uptake and antitumor peptide cleavage affected the antitumor activities of dual functional peptide-conjugated dendrimers.     

Uncertainty estimation in Co gamma-ray dosimetry at JAERI involving a two-way dose intercomparison study with NPL in the dose range 1–50 kGy

The uncertainties in ⁶⁰Co gamma-ray dosimetry at JAERI have been estimated by reviewing irradiation and calibration procedures. The uncertainty in dose delivered by the JAERI calibration system has been estimated to be 2.2% (2σ) and the uncertainty in dose measurement using JAERI alanine/ESR transfer dosimeters has been estimated to be 3.4% (2σ). A two-way dose intercomparison study between NPL and JAERI employing alanine-PS, alanine-paraffin, and dichromate dosimeters as transfer dosimeters was performed to confirm the estimated uncertainty over the dose range 1–50 kGy. Dose intercomparison results using both alanine and dichromate dosimeters show agreement within about 2%, which gives confidence in the estimated uncertainty in ⁶⁰Co gamma-ray dosimetry at JAERI.     

Excellent Redox Properties of Poly(thienylphenylamine)s

Triphenylamines with thienyl groups are electro‐oxidatively polymerized to yield the corresponding branched polymers on an electrode. The resulting polymers show significantly better redox properties, such as redox activity, catalytic activity, and conductivity when compared with for example the linear polymeric analog. The good properties of the branched polymers are based on the higher electronic conductivity (2–6 S/cm), since the branching provides multiple routes for charge carriers. The redox‐active polymers show high capacity (ca. 40 mC/cm²) and catalytic activity for the electron transfer of ferrocene on the electrode.     

Alternative molecularly imprinted polymeric membranes from a tetrapeptide residue consisting of D- or L-amino acids

Alternative molecularly imprinted polymeric membranes were prepared from a polystyrene resin bearing tetrapeptides consisting of D -amino acids or L-amino acids. The membrane prepared from a DLDE derivative (H-Asp(OcHex)-Leu-Asp(OcHex)-Glu(OBzl) CH₂ ) consisting of D -amino acids and imprinted by Boc-D -Trp recognizes the D-isomer in preference to the corresponding L -isomer and vice versa. The amino acid preferentially adsorbed by the membrane was selectively permeated by applying electrodialysis.