含腔电大尺寸导体目标电磁散射的一体化数值模拟

应用等效原理，通过引入口面上等效磁流将含腔导电目标电磁散射简化为腔内、外两个等效 问题. 腔内问题分段求解并应用级联法获得口面等效导纳矩阵；腔内外的耦合关系应用近似 边界元方法描述并由此获得口面等效磁流；最后，这一具有混合源的腔体内外一体化散射问 题则应用所提出的广义混合场积分方程方法建立电磁模型，并用多层快速多极子方法实现高 效数值求解. 实例计算结果与测试结果具有很好的一致性. 关键词： 含腔目标 电磁散射 混合场积分方程 数值分析     

蒙特卡罗计算机模拟应用一例

通过圆周率的计算，说明蒙特卡罗计算机模拟方法的应用过程     

C60醛类衍生物非线性光学特性研究

研究了加合不同取代基团的C60醛类衍生物的光学非线性性质。利用简并四波混频（DFMW）方法获得了C60醛类各衍生物的三阶光学非线性超级化率γ^(3)及相应的三阶光学非线性系数χ^(3)值。同时也研究了它们各自的光限幅特性。结果表明：不同的取代基对C60醛类衍生物三阶光学非线性及光限幅特性的影响不同。     

Grüneisen parameter for HCP iron at extreme compression

The Thomas–Fermi approximation gives the Grüneisen parameter γ=γ_∞=1/2 for all materials at extreme compression (P→∞ or V→0). After re-analyzing the existing experimental data of volume dependence of Grüneisen parameter γ of hexagonal close-packed (HCP) iron, we find that γ=1/2+a(V/V ₀)^1/3+b(V/V ₀) ⁿ , where a, b and n are constants. Based on this new form of γ, the second Grüneisen parameter q, the Debye temperature θ_D and the shear sound velocity v _s of HCP iron are discussed in the present work. It is found that the zero pressure second Grüneisen parameter q ₀=0.654, which is consistent with the previously determined value of HCP iron for Earth's core physics from Dubrovinsky et al. The calculations for the Debye temperature and the shear sound velocity are also found to be in good agreement with the experimental data.     

Energy transfer and mid-infrared luminescence properties of Tm3+ /Dy3+ codoped chalcohalide glasses

A series of chalcohalide glasses based on the composition 0.9 (Ge25 Ga5 S70)-0.1CsI doped with the different Tm3+ / Dy3+ ions ratio were synthesized by melt-quenching technique. The absorption spectra, and mid-infrared fluorescence of different glass samples under 800 nm laser excitation were measured. The results prove that, Tm3+ is an efficient sensitizer, which can enhance the Dy3+ : 2.9 microm fluorescence intensity significantly. A decrease in the intensity of 1.8 microm fluorescence and lifetimes of the Tm3+ : (3)F4 level occurred with increasing the concentration of Dy3+ ions from 0 to 1 Wt% where Tm3+ concentration was fixed to 0.5 Wt%. Also a wide spectral overlap between Tm+ : 1.8 microm emission and the absorption of Dy3+ : 6 H(15/2) --> (6)H(11/2) showed that the effective energy transfer between the two rare-earth ions was mainly attributed to the resonance energy from Tm3+: (3)F4 to Dy(3)+ : (6)H(11/2) level.     

Harmonic Mode-Locked Er-Doped Fiber Laser Based on a Microfiber-Based PbS Nanoparticle Saturable Absorber

Lead sulfide (PbS) is a nanomaterial with excellent optical and chemical properties, such as a narrow bandgap (0.37 eV), high thermal damage threshold, and high stability. Obviously, it is appropriate as a saturable absorber (SA) device for ultrafast photonics. However, PbS nanoparticles (NPs) as the SA of ultrashort harmonic mode-locked pulse still haven't been demonstrated at present. In this paper, the PbS NPs are made into an SA-device-based microfiber by optical deposition method and connected in an integrated Erbium-doped fiber laser. And both characteristics and nonlinear optical properties of PbS NPs have been systemically investigated. A fundamental frequency mode-locked pulsed laser is proposed, whose central wavelength is 1560 nm, and the pulse width is 1 ps. In addition, high repetition rate operations are achieved, with a maximum repetition rate of 833 MHz. This is the first time that PbS NPs are used to generate 96th-order harmonic mode-locking, and the corresponding pulse duration is 987 fs. It is demonstrated that PbS NPs are a kind of SA photonic material with excellent performance. It can improve the communication capacity by applying fiber communication, and it has potential application value even in material processing and optical comb.     

A Supercharged Fluorescent Protein as a Versatile Probe for Homogeneous DNA Detection and Methylation Analysis

Supercharged proteins are a new class of functional proteins with exceptional stability and potent ability to deliver bio‐macromolecules into cells. As a proof‐of‐principle, a novel application of supercharged proteins as a versatile biosensing platform for nucleic acid detection and epigenetics analysis is presented. Taking supercharged green fluorescent protein (ScGFP) as the signal reporter, a simple turn‐on homogenous method for DNA detection has been developed based on the polyionic nanoscale complex of ScGFP/DNA and toehold strand displacement. This assay shows high sensitivity and potent ability to detect single‐base mismatch. Furthermore, combined with bisulfite conversion, this ScGFP‐based assay was further applied to analyze site‐specific DNA methylation status of genomic DNA extracted from real human colon carcinoma tissue sample with ultrahigh sensitivity (4 amol methylated DNA).     

Responsive Exosome Nano‐bioconjugates for Synergistic Cancer Therapy

Exosomes hold great potential in therapeutic development. However, native exosomes usually induce insufficient effects in vivo and simply act as drug delivery vehicles. Herein, we synthesize responsive exosome nano‐bioconjugates for cancer therapy. Azide‐modified exosomes derived from M1 macrophages are conjugated with dibenzocyclooctyne‐modified antibodies of CD47 and SIRPα (aCD47 and aSIRPα) through pH‐sensitive linkers. After systemic administration, the nano‐bioconjugates can actively target tumors through the specific recognition between aCD47 and CD47 on the tumor cell surface. In the acidic tumor microenvironment, the benzoic‐imine bonds of the nano‐bioconjugates are cleaved to release aSIRPα and aCD47 that can, respectively, block SIRPα on macrophages and CD47, leading to abolished “don't eat me” signaling and improved phagocytosis of macrophages. Meanwhile, the native M1 exosomes effectively reprogram the macrophages from pro‐tumoral M2 to anti‐tumoral M1.     

Discovery of Novel Non-Oxime Reactivators Showing In Vivo Antidotal Efficiency for Sarin Poisoned Mice

A family of novel efficient non-oxime compounds exhibited promising reactivation efficacy for VX and sarin inhibited human acetylcholinesterase was discovered. It was found that aromatic groups coupled to Mannich phenols and the introduction of imidazole to the ortho position of phenols would dramatically enhance reactivation efficiency. Moreover, the in vivo experiment was conducted, and the results demonstrated that Mannich phenol L10R1 (30 mg/kg, ip) could afford 100% 48 h survival for mice of 2*LD₅₀ sarin exposure, which is promising for the development of non-oxime reactivators with central efficiency.