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排序方式: 共有239条查询结果,搜索用时 15 毫秒
51.
Shota OKUNO Toshihiro YAMASHITA Kengo SHIRADO Kenta KAWAMITSU Kaede YAMABE Yutaro ONISHI Taichi OGAMI Hiroto KAYASHIMA 《Physical Therapy Research》2021,24(3):225
Objective: The study aimed to demonstrate the significance of early postoperative physical therapy interventions on clinical outcomes by determining the influence of the distance walked under the supervision of a physical therapist in the early postoperative period after liver cancer. Methods: All consecutive patients who underwent surgery for liver cancer between April 2018 and March 2020 were eligible for enrollment in the study. The total walking distance during physical therapy till the third postoperative day was examined. The clinical outcomes comprised duration of postoperative hospital stay, time to independent walking, and occurrence of postoperative complications. For data analysis, the patients were divided into two groups: those who walked more than the median total distance (the long-distance group) and those who walked less than the median distance (the short-distance group). We used propensity score matching to match the background characteristics between the groups. Results: Of the 65 patients who were eligible, 14 patients were included in the two groups each, after matching. The long-distance walking group had a significantly shorter hospital stay (9.0 days vs. 11.0 days, p=0.008) and a shorter time to independent walking (3.5 days vs. 7.5 days, p=0.019) than the short-distance walking group. There were no significant differences in postoperative complications between the two groups (7.1% vs. 42.8%, p=0.08). Conclusion: In the early postoperative period after liver cancer surgery, increasing the walking distance under the supervision of a physical therapist is important for improving clinical outcomes. Further prospective studies are needed to confirm the findings of this study. 相似文献
52.
Yutaka Inoue Takashi Yamazoe Shota Watanabe Isamu Murata Ikuo Kanamoto 《Journal of inclusion phenomena and macrocyclic chemistry》2014,78(1-4):457-464
In this study, investigations were performed in regard to the possibility of complexation of actarit (ACT) with β-cyclodextrin (β-CD) for improving the solubility and dissolution rate. Complexes of β-CD and ACT (ACT/β-CD molar ratio = 1/1) were prepared using the cogrinding method. Formation of an ACT/β-CD inclusion complex by cogrinding was confirmed using powder X-ray diffraction measurement. The powder X-ray diffraction of the ground mixture (ACT/β-CD = 1/1) showed a halo pattern. The diffraction pattern of the ground mixture after storage at RH 82 %, 40 °C exhibited new diffraction peaks at 2θ = 11.6º and 17.8º, and differed from those of ACT and β-CD crystals. In vitro studies showed that the solubility and dissolution rate of ACT were significantly improved by complexation with β-CD with respect to the drug alone. In 1H-NMR measurement, changes in chemical shift (1H) suggested that the drug phenyl moiety was included in the cavities of β-CD mainly by hydrophobic interaction, and that the primary hydroxy side of β-CD was tightly associated with each drug. The results show clear evidence of intermolecular interaction between β-CD and ACT. 相似文献
53.
Makoto Oba Atsushi Shimabukuro Miyako Ono Mitsunobu Doi Masakazu Tanaka 《Tetrahedron: Asymmetry》2013,24(8):464-467
A method of synthesizing an optically active cyclic methionine analogue, 3-aminotetrahydrothiophene-3-carboxylic acid (At5c), is described. A Bucherer–Bergs reaction of 4,5-dihydro-3(2H)-thiophenone and the subsequent alkaline hydrolysis of a hydantoin, followed by Cbz protection of the amine, afforded racemic Cbz-At5c (±)-3 in excellent yield. Diastereomeric esters derived from Cbz-At5c (±)-3 and (R)-BINOL could be separated by column chromatography to give both diastereomers with >99% de. X-ray crystallographic analysis revealed the absolute configuration of the synthesized amino acid derived from the less polar diastereomeric ester to be (S). 相似文献
54.
55.
The cyclopropane-containing amino acid, dysibetaine CPa, isolated from Micronesian marine sponge, has been synthesized in 4.53% total yield over 12 steps starting from maleic anhydride to study the biological function in detail, by taking advantage of electron-withdrawing 4-nitrophenyl group. 相似文献
56.
57.
Huseyin Akbulut Shota Ando Shuhei Yamada Takeshi Endo 《Journal of polymer science. Part A, Polymer chemistry》2018,56(22):2522-2530
We report a methodology for the synthesis of Nε-phenoxycarbonyl-protected poly(l -lysine) on the side chain by chain growth polycondensation of Nα,Nε-bis(phenoxycarbonyl)-l -lysine proceeded through the selective elimination of phenol and CO2 from the Nα phenoxycarbonyl moiety at 50 °C in N,N-dimethylacetamide in the presence of a primary amine used as an initiator. After optimization of reaction condition, the addition of acetic acid during polycondensation proved effective for the realization of the predicted molecular weight and narrow dispersity of the corresponding polypeptide by adjusting the feed ratio of monomer to the amine initiator because of the suppression of interchain coupling that occurs between the amino terminus of poly(l -lysine) and the Nε-phenoxycarbonyl group on the polymer side chains. Furthermore, taking advantage of the potentially reactive Nε-phenoxycarbonyl moiety on the side chain, post-polymerization modification was effectively achieved by the nucleophilic reaction of amine compounds including primary, secondary, and aromatic amines through the formation of urea linkage, providing a useful platform for synthesis of selective side chain functionalization of poly(l -lysine) samples. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018 , 56, 2522–2530 相似文献
58.
Yusuke Hotta Tsukasa Kaneko Ryuji Hayashi Akito Yamamoto Shota Morimoto Junya Chiba Takenori Tomohiro 《化学:亚洲杂志》2019,14(3):398-402
We developed a novel diazirine‐based photolabeling agent having a (coumarin‐4‐yl)methyl ester scaffold, which exhibited multiple photochemical properties of crosslinking, fluorogenicity and cleavage. These properties can be kinetically regulated via photoinduced electron transfer between diazirine and coumarin moieties. The C?O bond of (coumarin‐4‐yl)methyl ester can be cleaved via photochemical excitation of coumarin moiety, that function has been initially quenched by the diazirine moiety. Upon diazirine photolysis with 365‐nm light, interacting protein was stably captured with photoactivatable ligand probe. Then, the unlocked cleavage function was activated with 313 nm light, and the reaction was accelerated in a weakly‐basic solution. The crosslinked protein could be selectively isolated with attachment of a small coumarin tag on the surface. This multi‐functional labeling agent has a great potential to facilitate LC‐MS/MS‐based protein identification. 相似文献
59.
Guanglin Huang Shota Hasegawa Dr. Yoshifumi Hashikawa Dr. Yuki Ide Prof. Dr. Takashi Hirose Prof. Dr. Yasujiro Murata 《Chemistry (Weinheim an der Bergstrasse, Germany)》2022,28(2):e202103836
An H2O2 molecule was isolated inside hydroxylated open-cage fullerene derivatives by mixing an H2O2 solution with a precursor molecule followed by reduction of one of carbonyl groups on its orifice. Depending on the reduction site, two structural isomers for H2O2@open-fullerenes were obtained. A high encapsulation ratio of 81 % was attained at low temperature. The structures of the peroxosolvate complexes thus obtained were studied by 1H NMR spectroscopy, X-ray analysis, and DFT calculations, showing strong hydrogen bonding between the encapsulated H2O2 and the hydroxy group located at the center of the orifice. This OH group was found to act as a kinetic stopper, and the formation of the hydrogen bonding caused thermodynamic stabilization of the H2O2 molecule, both of which prevent its escape from the cage. One of the peroxosolvates was isolated by HPLC, affording H2O2@open-fullerene with 100 % encapsulation ratio, likely due to the intramolecular hydrogen-bonding interaction. 相似文献
60.
We consider nonparametric Bayesian estimation of the drift coefficient of a multidimensional stochastic differential equation from discrete-time observations on the solution of this equation. Under suitable regularity conditions, we establish posterior consistency in this context. 相似文献