Synthesis of pyrimidine derivatives using N-bis(methylthio)methylenecyanamide

N-Bis(methylthio)methylenecyanamide ( 1 ) was allowed to react with active methylene compounds (methyl cyanoacetate, dimethyl malonate, ethyl acetoacetate, ethyl phenylacetate) in the presence of potassium carbonate or potassium hydroxide in dimethyl sulfoxide followed by the treatment using appropriate a base or an acid to give the corresponding 6-methylthiouracil derivatives in 15–80% yields. These uracil derivatives are found to be useful intermediates for the synthesis of 6-aminouracils and fused pyrimidine derivatives.     

Orientation control of perovskite thin films on glass substrates by the application of a seed layer prepared from oxide nanosheets

Orientation control of perovskite compounds was investigated by the application of a seed layer prepared from oxide nanosheets. An aqueous suspension of oxide nanosheets was prepared by the exfoliation of a layered compound of KCa₂Nb₃O₁₀ oxide grains. A seed layer composed of (TBA)Ca₂Nb₃O₁₀ nanosheets (TBA = tetrabutylammonium) was formed on a glass substrate by simply dip coating it in the suspension. Two kinds of perovskite compounds, LaNiO₃ (LNO) and Pb(Zr,Ti)O₃ (PZT) with a preferred orientation of (00l) were successfully grown on this seeded glass substrate. In this study, the relation between lattice mismatch and electrical properties is investigated. A large, oriented PZT film with a size of 5 ×4 cm shows an improved P-E hysteresis behavior by use of this orientation control.     

Catalytic asymmetric desymmetrization of cyclic meso-1,3- and 1,4-diols by a phosphinite derivative of quinidine

Asymmetric monobenzoylation reactions of cyclic meso-1,3- and 1,4-diols were catalyzed by a phosphinite derivative of quinidine to afford the corresponding monobenzoylated diol with good yield and enantioselectivity. [reaction: see text]     

Photoinduced electron-transfer systems consisting of electron-donating pyrenes or anthracenes and benzimidazolines for reductive transformation of carbonyl compounds

Photoinduced electron-transfer reactions of several ketone substrates were studied to evaluate the utilities of 1,6-bis(dimethylamino)pyrene (BDMAP), 1,6-dimethoxypyrene (DMP), 9,10-bis(dimethylamino)anthracene (BDMAA), and 9,10-dimethoxyanthracene (DMA) as electron-donating sensitizers cooperating with 2-aryl-1,3-dimethylbenzimidazolines. BDMAP and DMP generally led higher conversion of ketones and better yield of reduction products compared to BDMAA and DMA.     

Synthesis and physiological activity of novel tocopheryl glycosides

Vitamin E glycosides were synthesized and enzymatic hydrolysis was examined for use as potential pro-drugs, however, the glycoside bond was found to be stable. On the other hand, among the glycosides synthesized, dl-alpha-tocopherylglucoside (6b) and dl-alpha-tocopherylmannoside (6c) showed strong inhibitory action on histamine release from mast cells. In addition, 6c also showed a suppressive action on IgE antibody formation. Thus, tocopheryl glycoside showed new properties compared to tocopherol (vitamin E). In particular, 6c was shown to be a novel lead compound with excellent manifold anti-allergic activity and anti-inflammatory activity.     

13CNMR-Untersuchung der Taktizit?t von Poly-(RS)tert-butyloxiran, das durch Polymerisation mit tert-C4H9OK erhalten wurde

Ohne Zusammenfassung     

Isolation of xylose reductase gene ofPichia stipitis and its expression inSaccharomyces cerevisiae

Applied Biochemistry and Biotechnology - A NADPH/NADH-dependent xylose reductase gene was isolated from the xylose-assimilating yeast,Pichia stipitis. DNA sequence analysis showed that the gene...     

Diethyl phosphorocyanidated (DEPC). A novel reagent for the classical Strecker's α-amino nitrile synthesis

Diethyl phosphorocyanidate (DEPC) can be efficiently used for the synthesis of α-amino nitriles from carbonyl compounds and amines. The reaction may be called a modified Strecker synthesis.