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991.
Shokichi Tsukamoto Masahiro Takeuchi Takeharu Kawaguchi Emi Togasaki Atsuko Yamazaki Yasumasa Sugita Tomoya Muto Shio Sakai Yusuke Takeda Chikako Ohwada Emiko Sakaida Naomi Shimizu Keigo Nishii Meizi Jiang Koutaro Yokote Hideaki Bujo Chiaki Nakaseko 《Experimental & molecular medicine》2014,46(4):e89
LR11, also known as SorLA or SORL1, is a type-I membrane protein from which a large extracellular part, soluble LR11 (sLR11), is released by proteolytic shedding on cleavage with a disintegrin and metalloproteinase 17 (ADAM17). A shedding mechanism is presumed to have a key role in the functions of LR11, but the evidence for this has not yet been demonstrated. Tetraspanin CD9 has been recently shown to regulate the ADAM17-mediated shedding of tumor necrosis factor-α and intercellular adhesion molecule-1 on the cell surface. Here, we investigated the role of CD9 on the shedding of LR11 in leukocytes. LR11 was not expressed in THP-1 monocytes, but it was expressed and released in phorbol 12-myristate 13-acetate (PMA)-induced THP-1 macrophages (PMA/THP-1). Confocal microscopy showed colocalization of LR11 and CD9 proteins on the cell surface of PMA/THP-1. Ectopic neo-expression of CD9 in CCRF-SB cells, which are LR11-positive and CD9-negative, reduced the amount of sLR11 released from the cells. In contrast, incubation of LR11-transfected THP-1 cells with neutralizing anti-CD9 monoclonal antibodies increased the amount of sLR11 released from the cells. Likewise, the PMA-stimulated release of sLR11 increased in THP-1 cells transfected with CD9-targeted shRNAs, which was negated by treatment with the metalloproteinase inhibitor GM6001. These results suggest that the tetraspanin CD9 modulates the ADAM17-mediated shedding of LR11 in various leukemia cell lines and that the association between LR11 and CD9 on the cell surface has an important role in the ADAM17-mediated shedding mechanism. 相似文献
992.
Dr. Akitaka Ito Akihiro Shimizu Noriaki Kishida Yusuke Kawanaka Dr. Daisuke Kosumi Prof. Dr. Hideki Hashimoto Prof. Dr. Yoshio Teki 《Angewandte Chemie (International ed. in English)》2014,53(26):6715-6719
The excited‐state dynamics of pentacene derivatives with stable radical substituents were evaluated in detail through transient absorption measurements. The derivatives showed ultrafast formation of triplet excited state(s) in the pentacene moiety from a photoexcited singlet state through the contributions of enhanced intersystem crossing and singlet fission. Detailed kinetic analyses for the transient absorption data were conducted to quantify the excited‐state characteristics of the derivatives. 相似文献
993.
Zhikuan Zhou Dr. Yi Chang Dr. Soji Shimizu Dr. John Mack Christian Schütt Prof. Rainer Herges Prof. Zhen Shen Prof. Nagao Kobayashi 《Angewandte Chemie (International ed. in English)》2014,53(25):6563-6567
Two stable core‐modified rubyrins bearing one and two dithienylethene (DTE) units ( 1 and 2 ) have been synthesized. With one “closed‐form” DTE unit, 1 shows aromaticity associated with its conjugated circuit of 26 π‐electrons. In contrast, rubyrin 2 containing one “open‐form” DTE unit has nonaromatic properties. 相似文献
994.
Introduction of an Ionic Liquid into the Micropores of a Metal–Organic Framework and Its Anomalous Phase Behavior
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Kazuyuki Fujie Dr. Teppei Yamada Prof. Ryuichi Ikeda Prof. Hiroshi Kitagawa 《Angewandte Chemie (International ed. in English)》2014,53(42):11302-11305
Controlling the dynamics of ionic liquids (ILs) is a significant issue for widespread use. Metal–organic frameworks (MOFs) are ideal host materials for ILs because of their small micropores and tunable host–guest interactions. Herein, we demonstrate the first example of an IL incorporated within the micropores of a MOF. The system studied consisted of EMI‐TFSA (1‐ethyl‐3‐methylimidazolium bis(trifluoromethylsulfonyl)amide) and ZIF‐8 (composed of Zn(MeIM)2; H(MeIM)=2‐methylimidazole) as the IL and MOF, respectively. Construction of the EMI‐TFSA in ZIF‐8 was confirmed by X‐ray powder diffraction, nitrogen gas adsorption, and infrared absorption spectroscopy. Differential scanning calorimetry and solid‐state NMR measurements showed that the EMI‐TFSA inside the micropores demonstrated no freezing transition down to 123 K, whereas bulk EMI‐TFSA froze at 231 K. Such anomalous phase behavior originates from the nanosize effect of the MOF on the IL. This result provides a novel strategy for stabilizing the liquid phase of the ILs down to a lower temperature region. 相似文献
995.
Topotactic Conversion of β‐Helix‐Layered Silicate into AST‐Type Zeolite through Successive Interlayer Modifications
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Yusuke Asakura Ryosuke Takayama Dr. Toshimichi Shibue Prof. Dr. Kazuyuki Kuroda 《Chemistry (Weinheim an der Bergstrasse, Germany)》2014,20(7):1893-1900
AST‐type zeolite with a plate morphology can be synthesized by topotactic conversion of a layered silicate (β‐helix‐layered silicate; HLS) by using N,N‐dimethylpropionamide (DPA) to control the layer stacking of silicate layers and the subsequent interlayer condensation. Treatment of HLS twice with 1) hydrochloric acid/ethanol and 2) dimethylsulfoxide (DMSO) are needed to remove interlayer hydrated Na ions and tetramethylammonium (TMA) ions in intralayer cup‐like cavities (intracavity TMA ions), both of which are introduced during the preparation of HLS. The utilization of an amide molecule is effective for the control of the stacking sequence of silicate layers. This method could be applicable to various layered silicates that cannot be topotactically converted into three‐dimensional networks by simple interlayer condensation by judicious choice of amide molecules. 相似文献
996.
Vinyloxydichloroboranes (1) are scarcely found in literature2 probably because of certain unstable properties. We have found that some vinyloxyamino-chloroboranes (2), which can be prepared by formal substitution of one chlorine atom of 1 with a diethylamino group, are isolable stable compounds. 相似文献
997.
Various 2-substituted 1,4-dihydro-4,4,6-trimethyl-1-phenylpyrimidines and 1,6-dihydro-4,6,6-trimethylpyrimidines were synthesized independently. For these dihydropyrimidines, the physical data such as the uv, ir, and nmr spectra and the oxidation potential were compared. 2-Dimethylamino substituted dihydropyrimidine showed the lowest oxidation potential, which expected the similar reducing ability as dihydropyridines. 相似文献
998.
999.
Several quaternary ammonium bromides possessing long alkyl chains and their mixtures were found to be bromide ion conductors. The ionic conductivities of quaternary ammonium bromides themselves were lower than 10?9 S cm?1 at a room temperature. On the other hand, the eutectic mixtures of the quaternary ammonium bromides showed large increase of ionic conductivity. The best bromide ion conductors were found for the eutectic of Q5, Q7, Q8, and Q12: 4×10?8 S cm?1 at 30°C, and 6.3×10?6 S cm?1 at 50°C. Addition of asymmetric quarternary ammonium bromides had a negative effect on the ionic conductivity. These results were explained by a space filling factor in the solid. 相似文献
1000.