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871.
872.
Junyoung Seo Jae Do Yoo Minseong Kim Gayong Shim Yu-Kyoung Oh Rang-Woon Park Byungheon Lee In-San Kim Soyoun Kim 《Experimental & molecular medicine》2021,53(10):1592
Fibrin, one of the components of the extracellular matrix (ECM), acts as a transport barrier within the core of tumors by constricting the blood vessels and forming clots, leading to poor intratumoral distribution of anticancer drugs. Our group previously developed a microplasmin-based thrombolytic ferritin nanocage that efficiently targets and dissolves clots without causing systemic fibrinolysis or disrupting hemostatic clots. We hypothesized that the thrombolytic nanocage-mediated degradation of fibrin clots in the tumor ECM can lead to enhanced intratumoral drug delivery, especially for nanosized anticancer drugs. Fibrin clot deposition worsens after surgery and chemotherapy, further hindering drug delivery. Moreover, the risk of venous thromboembolism (VTE) also increases. Here, we used thrombolytic nanocages with multivalent clot-targeting peptides and fibrin degradation enzymes, such as microplasmin, to dissolve fibrin in the tumor microenvironment and named them fibrinolytic nanocages (FNCs). These FNCs target tumor clots specifically and effectively. FNCs efficiently dissolve fibrin clots inside of the tumor vessels, suggesting that they can mitigate the risk of VTE in cancer patients. Coadministration of FNC and doxorubicin led to improved chemotherapeutic activity in a syngeneic mouse melanoma model. Furthermore, the FNCs increased the distribution of Doxil/doxorubicin nanoparticles within mouse tumors. These results suggest that fibrinolytic cotherapy might help improve the therapeutic efficacy of anticancer nanomedicines. Thus, microplasmin-based fibrinolytic nanocages are promising candidates for this strategy due to their hemostatic safety and ability to home in on the tumor.Subject terms: Drug development, Drug delivery 相似文献
873.
874.
DooSung Lee MyungSeob Shim SungWan Kim Hyunjung Lee Insun Park Taihyun Chang 《Macromolecular rapid communications》2001,22(8):587-592
The BAB‐type triblock copolymers composed of a central poly(ethylene oxide) (PEO, M̄nPEO = 1 000) block and two poly[(D ,L ‐lactic acid)‐co‐(glycolic acid)] end blocks with molecular weights between 900 and 1 600 exhibited an interesting phase transition behavior. The copolymer aqueous solution can form micelles with PLGA loops in the core and a PEO shell and groups of micelles because of bridging between micelles caused by the PLGA blocks with raising temperature. A possible micellar gelation mechanism was suggested. 相似文献
875.
Dong Seok Kim Sang Chul Shim 《Journal of polymer science. Part A, Polymer chemistry》1999,37(15):2933-2940
Poly(silylenevinylene(bi)phenylenevinylene)s were synthesized by chloroplatinic acid-catalyzed hydrosilylation polymerization between α,ω-diethynylarenes and methylphenylsilane or diphenylsilane. The polymer structure was dependent on the substituent size of silane reagent. Poly(silylenevinylenephenylenevinylene)s showed fluorescence emission in the blue region. Optical and thermal properties of the polymers were extensively investigated. © 1999 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 37: 2933–2940, 1999 相似文献
876.
Dong Seok Kim Edwin Kroke Ralf Riedel Andreas O. Gabriel Sang Chul Shim 《应用有机金属化学》1999,13(7):495-499
Pyridine‐catalyzed reactions of methyldichlorosilane with bis(trimethylsilyl)carbodiimide afford a dichlorosilane‐derived anhydrous sol–gel material. Both trimethylchlorosilane formation and Si–H disproportionation act as crosslinking mechanisms. The dried gels form amorphous or crystalline materials, depending on the sample history. The xerogels gave Si/C/N ceramics when pyrolyzed at 1200 °C. Copyright © 1999 John Wiley & Sons, Ltd. 相似文献
877.
Akkinepally Bhargav Reddy I. Neelakanta Rao H. Jeevan Rao P. Srinivasa Shim Jaesool 《Journal of Solid State Electrochemistry》2023,27(4):955-967
Journal of Solid State Electrochemistry - The rational design of low-cost electrode materials with superior redox activity and high electrochemical conductivity has attracted extensive interest for... 相似文献
878.
J.B. Shim N. Yoshimoto M. Yoshizawa D.H. Yoon 《Crystal Research and Technology》2001,36(11):1209-1214
Erbium (Er3+) doped LiNbO3 single crystal thin films have been grown LiNbO3 (001) substrate by the liquid phase epitaxy method. The crystallinity was determined by high‐resolution X‐ray diffraction. The lattice mismatch between Er3+ doped LiNbO3 films and LiNbO3 (001) substrate was investigated by X‐ray rocking curve analysis. Also we studied the structural characteristics of Er3+ doped LiNbO3 films and surface morphology dependent on the film thickness. 相似文献
879.
H.Y. Byun I.J. Chung Y.-S. Suh H.K. Shim D.Y. Kim C.Y. Kim 《Macromolecular Symposia》2003,192(1):151-160
A blend of a newly synthesized polyfluorene(PDHBF) and polyvinylcarbazole(PVK) exhibits a photoluminescence(PL) emission spectrum of PDHBF without an increase in the PL intensity on photoexcitation at 340 nm, the UV-visible absorption maximum of PVK, despite of a substantial spectrum overlap. However, the indirect photoexcitation of the blend suppresses the secondary emission of the PL with the maximum at 520 nm. The chromophores generating the secondary emission are formed when the chromophores are photoexcited above the critical energy level of an excited state. The chromophores formed by the energy transfer have energy lower than the critical energy and fail to form the excimers. A low temperature PL study of the blend in a cryogenic chamber proves that the energy transfer in the system takes place mainly between the excimers of PVK generated by the partially eclipsed dimeric states of two carbazole units and the fluorophores of PDHBF. 相似文献
880.
Prof. Dr. Sunghun Jung Dr. Joon Kyo Seo Dr. Il-Chan Jang Dr. Jihun Kim Prof. Dr. Jae-Hyun Shim Dr. Jung-Je Woo 《Chemphyschem》2023,24(21):e202300438
We defined four major deterioration factors (electrolyte loss (EL), lithium loss (LL), lithium precipitation (LP), and compound deterioration (CD)). Then, we derived eleven key performance indicators (KPIs) for comparative analysis. After that, we fabricated three deteriorated cells for each of three deterioration factors (EL, LL, and LP) and one cell with CD (for verification) with four individual (dis)charging experiment manuals. The two major contributions of this study are the performance of 1) trend analysis to determine a suitable diagnostic metric by inspecting the eleven KPIs and 2) comparison analysis of and to verify the effectiveness of utilizing as a real-time deterioration diagnostic factor using a concept of model-in-the-loop simulation. The results show that 1) has the most conspicuous trendline tendency among the eleven comparison targets for all four major deterioration factors, and 2) the angle difference between the two trends of and lies within a minimum of 9° and a maximum of 43° (with a sscale on the x-axis and a scale on the y-axis for a clear trend line analysis). From this, we can conclude that the trendline-based real-time deterioration analysis employing may be practically applicable to a limited extent. 相似文献