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961.
为了寻找高效、低毒的抗肿瘤药物,基于分子杂交的策略,将苯并[b]氮杂?结构引入查尔酮母体结构中,设计了12个未见文献报道的苯并[b]氮杂?-查尔酮杂合物(7a~7l)。并以苯胺为原料,经N-烷基化、羰基化、水解、环化和Claisen-Schmidt缩合反应合成了7a~7l,其结构经1HNMR, 13CNMR和HR-MS(ESI)表征。采用MTT法评估了目标化合物对人胃癌细胞(HGC-27)、人肝癌细胞(HepG2)、人非小细胞肺癌细胞(A549)和人正常胃粘膜上皮细胞(GES-1)的抗增殖活性,并进一步采用流式细胞术和蛋白印迹法实验在细胞和蛋白水平上探究了活性最优化合物的抗肿瘤机制。结果表明:目标化合物对HGC-27细胞表现出较高的抗增殖活性,其中化合物7d对HGC-27细胞的抗增殖活性最强(IC50=0.78 μmol•L-1),优于阳性对照顺铂(IC50=7.38 μmol•L-1),同时其对人正常细胞GES-1的毒性较低(IC50=22.77 μmol•L-1, SI=29.19),弱于阳性对照顺铂(IC50=9.51 μmol•L-1, SI=1.29)。抗肿瘤机制研究表明:化合物7d能够将癌细胞HGC-27的细胞周期阻滞在G2/M期,并通过增加促凋亡蛋白Bax和降低抗凋亡蛋白Bcl-2的表达来诱导HGC-27细胞的凋亡。
相似文献
962.
Daozhong Hu Lai Chen Jun Tian Yuefeng Su Ning Li Gang Chen Yulu Hu Yueshan Dou Shi Chen Feng Wu 《中国化学》2021,39(1):165-173
Lithium plating on graphite anode is triggered by harsh conditions of fast charge and low temperature, which significantly accelerates SOH (state of health) degradation and may cause safety issues of lithium ion batteries (LIBs). This paper has reviewed recent research progress of lithium plating on graphite anode. Firstly, we summarize the forming mechanisms of Li plating with corresponding influence factors, the detecting methods and hazard of Li plating. Then, approaches to suppress Li plating are discussed, including anode surface modification, electrolyte composition optimization and development of optimal charge strategies. Finally, we conclude and propose the remaining challenges and prospects in terms of mechanism research, detecting approaches, and suppressing methods of Li plating. This review highlights the development of Li plating research and plays a guiding rule of further study on Li plating in LIBs. 相似文献
963.
964.
965.
Hui Shi Ziheng Wang Dr. Qin Ouyang Prof. Jianwei Hao Dr. Xianbo Huang 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(30):8030-8039
Retaining nitrogen for polyacrylonitrile (PAN) based carbon anode is a cost-effective way to make full use of the advantages of PAN for sodium-ion batteries (SIBs). Here, a simple strategy has been successfully adopted to retain N atoms in situ and increase production yield of a novel composite PAZ by mixing 3 wt % of zinc borate (ZB) with poly (acrylonitrile-co-itaconic acid) (PANIA). Among the prepared carbonised fibre (CF) samples, PAZ-CF-700 maintains the highest N content, retaining 90 % of the original N from PANIA. It represents the highest capacity storage contribution (80.55 %) and the lowest impedance Rct (117 Ω). Consequently, the specific capacity increases from 60 mAh g−1 of PANIA-CF-700 to 190 mAh g−1 of PAZ-CF-700 at a current density of 100 mA g−1. At the same time, PAZ-CF-700 exhibits a good rate performance and excellent long-term cycling stability with a specific capacity of 94 mAh g−1 after 4000 cycles at 1.6 A g−1. 相似文献
966.
Wen-Jie Shi Dan Liu Xin Li Dr. Sha Bai Prof. Yao-Yu Wang Prof. Dr. Ying-Feng Han 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(29):7853-7861
The incorporation of functional groups into the cavity of discrete supramolecular coordination cages (SCCs) will bring unique functions and applications. Here, three dicarboxylate ligands (H2 L1 Cl, H2 L2 Cl and H2 L3 Cl) containing N-heterocyclic carbene (NHC) precursors as linkers were introduced to construct SCCs by combining with two C3-symmertic (CpZr)3(μ3-O)(μ2-OH)3 clusters as three-connect vertices, resulted in a series of rugby-like V2E3 (V=vertex, E=edge) type homoleptic cages ( SCC-1 , SCC-2 and SCC-3 ). However, V4E6-type tetrahedral cages ( SCC-4 and SCC-5 ), incorporating six Au-NHC moieties, were obtained when the corresponding NHC-gold(I) functionalized ligands (H2 L1 Au, H2 L2 Au) were applied. For the first time, we present a trackable CpZr-involved cage to cage conversion to generate a heteroleptic V2E3 cage ( SCC-6 ) from two homoleptic cages ( SCC-2 and SCC-5 ) with different geometries of V2E3 and V4E6. The heteroleptic assembly SCC-6 can also be formed upon a subcomponent displacement strategy. The structural transformation and reassembly processes were detected and monitored by 1H NMR spectroscopy and electrospray-ionization mass spectrometry. The formation of heteroleptic assembly was further supported by single crystal X-ray diffraction analysis. Moreover, homoleptic cage SCC-2 possesses a trigonal bipyramidal cationic cavity allowing the encapsulation of a series of sulfonate anionic guests. 相似文献
967.
Shilin Jiang Dr. Jianhui Lan Dr. Lin Wang Dr. Yalan Liu Yuke Zhong Yichuan Liu Dr. Liyong L.-Y. Yuan Dr. Lirong Zheng Prof. Zhifang Chai Prof. Weiqun Shi 《Chemistry (Weinheim an der Bergstrasse, Germany)》2021,27(45):11721-11729
Molten salt electrolysis is a vital technique to produce high-purity lanthanide metals and alloys. However, the coordination environments of lanthanides in molten salts, which heavily affect the related redox potential and electrochemical properties, have not been well elucidated. Here, the competitive coordination of chloride and fluoride anions towards lanthanide cations (La3+ and Nd3+) is explored in molten LiCl-KCl-LiF-LnCl3 salts using electrochemical, spectroscopic, and computational approaches. Electrochemical analyses show that significant negative shifts in the reduction potential of Ln3+ occur when F− concentration increases, indicating that the F− anions interact with Ln3+ via substituting the coordinated Cl− anions, and confirm [LnClxFy]3−x−y (ymax=3) complexes are prevailing in molten salts. Spectroscopic and computational results on solution structures further reveal the competition between Cl− and F− anions, which leads to the formation of four distinct Ln(III) species: [LnCl6]3−, [LnCl5F]3−, [LnCl4F2]3− and [LnCl4F3]4−. Among them, the seven-coordinated [LnCl4F3]4− complex possesses a low-symmetry structure evidenced by the pattern change of Raman spectra. After comparing the polarizing power (Z/r) among different metal cations, it was concluded that Ln−F interaction is weaker than that between transition metal and F− ions. 相似文献
968.
Zhao Tianqi Luo Tianzi Fang Bo Shi Lijiang Jin Yongxing Zhou Pengwei Yao Dong Li Chenxia Jing Xufeng Hong Zhi 《Journal of Russian Laser Research》2021,42(5):586-597
Journal of Russian Laser Research - The zero-refractive-index metamaterials have excellent electromagnetic properties, which provide new ideas and methods to realize the control of electromagnetic... 相似文献
969.
First-principles study of the co-effect of carbon doping and oxygen vacancies in ZnO photocatalyst 下载免费PDF全文
Although tuning band structure of optoelectronic semiconductor-based materials by means of doping single defect is an important approach for potential photocatalysis application,C-doping or oxygen vacancy(Vo)as a single defect in ZnO still has limitations for photocatalytic activity.Meanwhile,the influence of co-existence of various defects in ZnO still lacks sufficient studies.Therefore,we investigate the photocatalytic properties of ZnOx C0.0625(x=0.9375,0.875,0.8125),confirming that the co-effect of various defects has a greater enhancement for photocatalytic activity driven by visible-light than the single defect in ZnO.To clarify the underlying mechanism of co-existence of various defects in ZnO,we perform systematically the electronic properties calculations using density functional theory.It is found that the coeffect of C-doping and Vo in ZnO can achieve a more controllable band gap than doping solely in ZnO.Moreover,the impact of the effective masses of ZnOxC0.0625(x=0.9375,0.875,0.8125)is also taken into account.In comparison with heavy Vo concentrations,the light Vo concentration(x=0.875)as the optimal component together with C-doping in ZnO,can significantly improve the visible-light absorption and benefit photocatalytic activity. 相似文献
970.
The chiral phase transition and equation of state are studied within a novel self-consistent mean-field approximation of the two-flavor Nambu-Jona-Lasinio model. In this newly developed model, modifications to the chemical μ and chiral chemical \begin{document}$\mu_5$\end{document} ![]()
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potentials are naturally included by introducing vector and axial-vector channels from Fierz-transformed Lagrangian to the standard Lagrangian. In the proper-time scheme, the chiral phase transition is a crossover in the \begin{document}$T-\mu$\end{document} ![]()
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plane. However, when \begin{document}$\mu_5$\end{document} ![]()
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is incorporated, our study demonstrates that a first order phase transition may emerge. Furthermore, the chiral imbalance will soften the equation of state of quark matter. The mass-radius relationship and tidal deformability of quark stars are calculated. The maximum mass and radius decrease as \begin{document}$\mu_5$\end{document} ![]()
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increases. Our study also indicates that the vector and axial-vector channels exhibit an opposite influence on the equation of state. 相似文献