Actinolactomycin,a New 2-Oxonanonoidal Antitumor Antibiotic Produced by Streptomyces flavoretus 18522,and its Inhibitory Effect on the Proliferation of Human Cancer Cells

In the course of our screening for new anticancer agents from microbial resources usingmammalian cancer tsFT210 cells1-3, we found that the fermentation broth of anactinomycete strain 18522 significantly inhibited the cell cycle of tsFT210 cells at theG0/G1 phase. From the fermentation broth of this strain, we have now isolated a new2-oxonanonoidal anitumor antibiotic, named actinolactomycin 1, through a bioassay-guided separation procedure. In this communication, the isolation, structure de…     

有机试剂结构与性质的研究 Ⅺ 吡啶偶氮衍生物结构与吸收光谱的研究

本文应用PPP-SCF-MO法研究了吡啶偶氮苯衍生物结构与吸收光谱的关系。本文认为吡啶偶氮苯波长最长的吸收峰为分子內荷移光谱。本文还研究了取代基对吸收光谱的影响,得到了λ_(最大)与“净电荷”Q的线性方程。     

Structural Revision of Isovalertatins D03 and D23 Isolated from the Culture Filtrate of Streptomyces luteogriseus

In a program of sequentially investigating the chemical constituents of the complex, WC670, extracted from the culture filtrate of Streptomyces luteogriseus, we found it contains the reported aminooligosaccharides, yiwutadings B-F. But, when verifying their structures, there were several inconsistencies against the corresponding ESI ion trap multistage mass spectra. Our previous paper1 reported the structural revision of yiwutadings F, D and C, and these monomers were re-designated as isov…     

A TDDFT study on the hydrogen-bonding effect on ESIPT mechanism for [2,2′-bipyridyl]-3,3′-diol-(H2O) n (n = 0, 1, 2) clusters: single or double?

The excited-state intramolecular proton transfer (ESIPT) mechanisms of [2,2′-bipyridyl]-3,3′-diol (BP(OH)₂) in gas are studied by using density functional theory (DFT) and time-dependent density functional theory (TDDFT) methods. The intramolecular hydrogen bond (H-bond) is strengthened in the first excited-state in view of the structural parameters and infrared (IR) vibrational frequencies. The enhanced intramolecular H-bond is favourable for ESIPT process. The effect of the extra intermolecular H-bond between BP(OH)₂ and water on ESIPT is considered. The potential energy surfaces, molecular electrostatic potential, topological analysis, frontier molecular orbitals, absorption and fluorescence spectra are investigated. Our calculated results show that the intermolecular H-bond enhances the intramolecular H-bond, changes the mechanism and decreases the barrier height of ESIPT process.     

基于压电阻抗的结构缺陷评价方法的实验研究

 介绍基于压电动态阻抗的结构健康诊断新技术. 在阐述其基本原理 的基础上，用压电陶瓷作为驱动源产生的动态阻抗信息，从实验的角度定 性评价几种结构缺陷，证实该方法的可行性.     

非完整约束系统几何动力学研究进展:Lagrange理论及其它

近10年来, 非完整力学的发展主要集中在两个相互关联的方向上, 一个是非完整运动规划, 另一个则是非完整约束系统的几何动力学, 这两个研究方向都充分地利用了现代几何学, 如纤维丛理论、辛流形和Poisson流形结构等等.本文主要综述非完整约束系统几何动力学的外附型和内禀型Lagrange理论, 包括非定常力学系统所需要的射丛几何学的基本概念、射丛按约束的直和分解、约束流形上的水平分布、D'Alembert-Lagrange方程与Chaplygin方程的整体描述、以及Riemann-Cartan流形上的非完整力学, 文中对Chetaev条件和d-δ交换关系的几何意义作了深入讨论.除此之外, 简要评述非完整力学的Hamilton理论与赝Poisson结构、Noether对称性和Lie对称性、动量映射与对称约化、Vakonomic动力学等几个非常重要专题的研究进展.      

用硝基磺酚S分光光度法测定蛋白质

1引言用光度法测定蛋白质以其重视性好、灵敏度高而在临床检验和生化实验中得到应用。实验表明,硝基磺酚S在酸性条件下可与蛋白质作用生成蓝色复合物。此方法用于实际人血清样品中蛋白质的测定,结果准确,回收率高,方法简便。2实验方法向钻niL比色管中依次加入2．SInL硝基磺酚s简写回二jlnLEritto。hb＿（R刚缓冲液、6InL无水乙醇及一定体积的牛血清白蛋白（BSA）标准溶液,用去离子水稀释至刻度,摇匀。以相应试剂空白为参比,用Icrn比色M于685run波长处测定溶液的吸光度。3结果与讨论3．互吸收光谱pH3．l时硝基磺酚S的最大吸收…     

Room temperature deformable shape memory composite with fine‐tuned crystallization induced via nanoclay particles

It is known that particular types of semi‐crystalline/elastomer polymer blends exhibit shape memory effects (SME) due to the dispersion of two immiscible phases. In this study, the crystal structure of polylactic acid (PLA)/ thermoplastic polyurethane (TPU) based shape memory polymer (SMP) is altered by incorporating small amounts of montmorillonite (MMT) nanoclay. The results indicate the incorporation of MMT can improve the compatibility of the two different polymers. Moreover, the presence of MMT affects the total crystallinity of the SMP and improves mechanical properties. Lastly, uniaxial stretching deformation can be applied to the SMP at room temperature conditions while maintaining its shape memory properties. With 1 wt % MMT particles, the recovery ratio (Rr) was nearly 95%, which indicated a strong recovery effect. The shape‐fixing ratio (Rf) remained above 95% for all composites due to plastic deformation applied at room temperature. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2017 , 55, 1197–1206     

Statistical and thermodynamic properties of binary self-condensing vinyl polymerization

The thermodynamic properties of a binary self-condensing vinyl polymerization system consisting of monomers and inimers are investigated by the principle of statistical mechanics.In detail,in terms of two types of canonical partition functions constructed from different viewpoints,the equilibrium free energy,the law of mass action and the size distribution of hyperbranched polymers are obtained.As an application,the specific heat,equation of state and isothermal compressibility concerning the polymerization...     

One-dimensional Copper(II) Complex Constructed with Nitrate Counter-anion as Bitopic Connector

The design and synthesis of supramolecular structures has become an area of intense research in recent two decades.By carefully choosing the ions and ligands,frameworks with interesting and desirable properties can be created1-2.Essence of supramolecular chemistry is the self-assembly process of diversified interactions,such as metal-ligand coordination,hydrogen bonding,π-πstacking,etc.In contrast to the well-studied metal ions and ligands,there are relatively few examples about anionic func…