飞机撞击建(构)筑物研究进展

飞机撞击重要建(构)筑物会导致灾难性后果。本文从试验研究、理论分析、数值模拟等3个方面对飞机撞击建(构)筑物的国内外研究现状,相关研究难点、需要注意的问题和研究方向及趋势进行总结,包括:缩比试验的系统和验证,飞机撞击力模型,撞击所致局部破坏计算公式,飞机和建(构)筑物的精细化建模,撞击所致振动特性,撞击荷载和火荷载对结构的耦合毁伤效应,一般模型和精细化模型、解耦和耦合方法以及不同数值模拟程序计算结果的对比分析等方面,以期为后续研究提供参考。     

Synthesis and Structure–Activity Relationship Studies of Benzimidazole-4,7-dione-Based P2X3 Receptor Antagonists as Novel Anti-Nociceptive Agents

P2X3 receptors (P2X3R) are ATP-gated ion channels predominantly expressed in C- and Aδ-fiber primary afferent neurons and have been introduced as a novel therapeutic target for neurological disorders, including neuropathic pain and chronic cough. Because of its localized distribution, antagonism of P2X3R has been thoroughly considered, and the avoidance of issues related to CNS side effects has been proven in clinical trials. In this article, benzimidazole-4,7-dione-based derivatives were introduced as a new chemical entity for the development of P2X3R antagonists. Starting from the discovery of a hit compound from the screening of 8364 random library compounds in the Korea Chemical Bank, which had an IC₅₀ value of 1030 nM, studies of structure–activity and structure–property relationships enabled further optimization toward improving the antagonistic activities as well as the drug’s physicochemical properties, including metabolic stability. As for the results, the final optimized compound 14h was developed with an IC₅₀ value of 375 nM at P2X3R with more than 23-fold selectivity versus P2X2/3R, along with properties of metabolic stability and improved solubility. In neuropathic pain animal models evoked by either nerve ligation or chemotherapeutics in male Sprague-Dawley rats, compound 14h showed anti-nociceptive effects through an increase in the mechanical withdrawal threshold as measured by von Frey filament following intravenous administration.     

卷积神经网络在气体泄漏超声识别中的应用

为了克服现有气体泄漏检测方法的不足,提出一种基于卷积神经网络的气体泄漏超声信号识别方法。在设计卷积神经网络网络结构时,通过多次预训练确定网络层数、卷积核数目和尺寸、全连接层神经元数目。同时,选择Inception模块平衡网络宽度和深度,防止过拟合的同时提高网络对尺度的适应性。通过输气管道泄漏实验平台模拟工况中常见的阀门泄漏和垫片泄漏,利用短时傅里叶变换进行时频图表征,在此基础上,建立二分类模型和不同泄漏类型的三分类模型。结果表明,相比二分类模型,不同泄漏类型的三分类模型识别准确率有所降低,添加Inception模块可以有效提高三分类模型的性能。     

A BODIPY-based highly emissive dye with thiophene-based branch harvesting the light

ABSTRACT

A novel BODIPY-based dye with highly emissive character was configured by Sonogashira coupling and routinely characterized by NMR and MS technology. The emission of dye was investigated in solution/film/solid and shows intensive emission. In solution, the emission peak appeared around 510 nm with little influence by the polar environment. The terthiophene plays an effective antenna effect, harvesting the light and transferring the energy to BODIPY. The pseudo Stoke's shift enlarged to ～170 nm in solution. In film, the emission peak shifted to 563 nm in polycarbonate matrix. And it shifted further to 585 nm in solid due to the highly twisted structure, which avoided closely regular-tight packing. The dye rendered an intense fluorescence, good optothermal stability, and high fluorescence quantum yield (0.55). The solid emission showed highly red emission with Commission Internationale de L'Eclairage (CIE) coordinates of (X = 0.69, Y = 0.31). Thus, the synthesized dye is idea candidate for emitting materials.     

Small angle x—ray scattering study on the conformation of polystyrene in toluene during adding anti—solvent CO2

The conformatiopn of polystyrene in the anti-solvent process of supercritical fluids(compressed CO2 polystyrene toluene)has been studied by small angle x-ray scattering with synchrotron radiation as an x-ray source.Coilto-globule transformation of the polystyrene chain was observed with the increase of the anti-solvent CO2 pressure;i.e.polystrene coiled at a prssure lower than the cloud point pressure(Pc)and turned into a globle with a uniform density at pressures higher than Pc.Fractal behaviour was also found in the chain contraction.and the mass fractal dimension increased with increasing CO2 pressure.     

全连续弱内向映象的不动点指数及多重不动点定理

本文通过研究与全连续弱内向映象相应的Banach空间中凸闭集上常微分方程解的性质，定义了有界凸闭集上局部Lip.全连续弱内向映象的不动点指数并利用它给出了一个弱内向映象的三解定理．     

关于主伪内射模

对于环R．一个右R模被叫做主伪内射模。若每一个从M的主子模到M的单同态可以扩张为M的自同态．主伪内射是主拟内射的推广．在本文中,我们给出了一些主伪内射的性质并讨论什么情况下主伪内射模是主拟内射模的问题．     

块α-对角占优矩阵的讨论

应用矩阵块对角占优理论,讨论了块α-对角占优矩阵之间的蕴含关系,并得到了条件最弱的块严格α1-双对角占优的两个等价表征,并作为应用给出了块H矩阵新的判定准则,最后用数值例子说明结果的有效性.     

具扰动项的L—R型迁移方程的谱问题

本文在Lp（1≤P〈＋∞）空间上,研究了种群细胞增生中一类具扰动项的L—R模型,证明了这类模型相应的迁移算子生成半群的Dyson—Phillips展式的9阶余项R9（t）在L1空间上是弱紧和在Lp（1〈P〈＋∞）空间上是紧的,从而获得了该迁移算子的谱在右半平面上仅由有限个具有限代数重数的离散本征值组成及该迁移方程解的渐近稳定性等结果．