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A rapid gas chromatography-tandem mass spectrometry (GC-MS/MS) analytical method was developed for the simultaneous analysis of 7 estrogenic hormones (17α-estradiol, 17β-estradiol, estrone, mestranol, 17α-ethynylestradiol, levonorgestrel, estriol) and 5 androgenic hormones (testosterone, androsterone, etiocholanolone, dihydrotestosterone, androstenedione) in aqueous matrices. This method is unique in its inclusion of all 12 of these estrogens and androgens and is of particular value due to its very short chromatographic run time of 15 min. The use of isotope dilution for all analytes ensures the accurate quantification, accounting for analytical variabilities that may be introduced during sample processing and instrumental analysis. Direct isotopically labelled analogues were used for 8 of the 12 hormones and satisfactory isotope standards were identified for the remaining 4 hormones. Method detection levels (MDLs) were determined to describe analyte concentrations sufficient to provide a signal with 99% certainty of detection. The established MDLs for most analytes were 1-5 ngL(-1) in a variety of aqueous matrices. However, slightly higher MDLs were observed for etiocholanolone, androstenedione, testosterone, levonorgestrel and dihydrotestosterone in some aqueous matrices. Sample matrices were observed to have only a minor impact on MDLs and the method validation confirmed satisfactory method stability over intra-day and inter-day analyses of surface water and tertiary treated effluent samples. 相似文献
75.
The role of metal ions in Alzheimer's disease etiology is unresolved. For the redox-active metal ions iron and copper, the formation of reactive oxygen species by metal amyloid complexes has been proposed to contribute to Alzheimer's disease neurodegeneration. For copper, reactive oxygen species are generated by copper redox cycling between its 1+ and 2+ oxidation states. Thus, the AβCu(I) complex is potentially a critical reactant associated with Alzheimer's disease etiology. Through competitive chelation, we have measured the affinity of the soluble copper-binding domain of the amyloid-β peptide for Cu(I). The dissociation constants are in the femtomolar range for both wild-type and histidine-to-alanine mutants. These results indicate that Cu(I) binds more tightly to monomeric amyloid-β than Cu(II) does, which leads us to propose that Cu(I) is a relevant in vivo oxidation state. 相似文献
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We present a theoretical analysis of the electronic absorption spectra of tetracene in (4)He droplets based on many-body quantum simulations. Using the path integral ground state approach, we calculate one- and two-body reduced density matrices of the most strongly localized He atoms near the molecule surface and use these to investigate the helium ground-state quantum coherence and correlations when tetracene is in its electronic ground and excited states. We identify a trio of quasi-one-dimensional, strongly localized atoms adsorbed along the long axis of the molecule that show some quantum coherence among themselves but far less with the remaining solvating helium. We evaluate the single-particle natural orbitals of the localized He atoms by diagonalization of the one-body density matrix and use these to construct single- and many-particle solvating helium basis states with which the zero-phonon spectral features of the tetracene-(4)He(N) absorption spectrum are then calculated. The absorption spectrum resulting from the three-body density matrix for the strongly bound trio of helium atoms is in very good agreement with the experimental data, accounting quantitatively for the anomalous splitting of the zero-phonon line [Hartmann, M.; Lindinger, A.; Toennies, J. P.; Vilesov, A. F. Chem. Phys. 1998, 239, 139; Krasnokutski, S.; Rouillé, G.; Huisken, F. Chem. Phys. Lett. 2005, 406, 386]. Our results indicate that the combination of strong localization and the quasi-one-dimensional nature of trios of helium atoms adsorbed along the long axis of tetracene leads to a quantum coherent, yet highly correlated ground state for the helium density closest to the molecule. The spectroscopic analysis shows that this feature accounts quantitatively for the anomalous splittings and hitherto unexplained fine structure observed in the absorption spectra of tetracene and suggests that it may be responsible for the corresponding zero-phonon splittings in other quasi-one-dimensional planar aromatic molecules. 相似文献
78.
Roe C Moragas Solá T Sasraku-Neequaye L Hobbs H Churcher I MacPherson D Stockman RA 《Chemical communications (Cambridge, England)》2011,47(26):7491-7493
The synthetic utility of S-mesitylsulfinimines for the synthesis of chiral amines and aziridines was examined through their reactions with Grignard reagents, with the ylides derived from trimethylsulfonium iodide and S-allyl-tetrahydrothiophenium bromide and through an aza-Darzens manifold, affording convenient access to a diverse range of highly substituted chiral amines and aziridines in high yields and excellent stereoselectivities. 相似文献
79.
Deglint E Martens H Edwards E Boon N Dance P Weinberg N 《Physical chemistry chemical physics : PCCP》2011,13(2):438-440
We propose a novel approach toward calculating activation and reaction volumes based on MD simulations of reaction systems. The accuracy of the calculated volumes, verified by the comparison to the experimental data, is suitable for quantitative analysis of the experimental volumes of activations in terms of structural parameters of the corresponding transition states. 相似文献
80.
Theoretical predictions of solubility, typically accomplished by comparing the chemical potential of pure solid and solution, currently suffer from a lack of accuracy. We suggest an alternative method for predicting solubility based on molecular dynamics simulations of the behaviour of a small seed crystalline cluster probe in solutions of varying concentrations. The size dynamics of a properly chosen seed cluster that dissolves in unsaturated solutions and grows in size in supersaturated solutions is indicative of the saturation point. This approach is illustrated by its application to NaCl in water. 相似文献