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71.
We present extensive numerical results applying the finite size scaling method to the theory of electrons in disordered systems. A method is developed for studying the localisation length in 1-dimensional systems of finite cross section. By studying these results as a function of cross-section and using scaling ideas, we derive the critical properties of 2-D and 3-D systems. We calculate transport properties as a function of temperature which can then be compared with experiment. 相似文献
72.
MacKinnon AL Garrison JL Hegde RS Taunton J 《Journal of the American Chemical Society》2007,129(47):14560-14561
Photoaffinity labeling is a powerful tool to identify protein targets of biologically active small molecules, yet is often limited by the size, chemical properties, and availability of photoreactive groups. We report an improved synthesis of photo-leucine, a diazirine-based photoreactive analogue of leucine, and demonstrate its incorporation into a cyclodepsipeptide inhibitor of cotranslational translocation. Photoaffinity labeling in a crude membrane fraction, followed by "click chemistry" with a rhodamine-azide reporter, enabled the identification of Sec61alpha, the structural core of the Sec61 translocation channel, as the inhibitor's target. 相似文献
73.
James A. Rego Jamie A.A. Harvey Andrew L. MacKinnon Elysse Gatdula 《Liquid crystals》2013,40(1):37-43
The Sharpless asymmetric dihydroxylation has been utilised to synthesise a new glassy chiral dopant with large helical twisting power (β) and remarkable solubility in nematic liquid crystal hosts. Values of β range between +30.7 and +47.7 μm?1 in five different nematic hosts. A 26% mixture in E7 is homogenous indefinitely and induces a room-temperature blue phase. 相似文献
74.
Host-guest complexation between the dicationic viologen 1-tri(ethylene glycol)-1'-methyl-m-xylyl-4,4'-bipyridinium and cucurbit[7]uril (CB7) was studied at pH = 4.5 in water. The stability constants of the mono- and bis-CB7 adducts were determined at 25 °C by UV-vis spectroscopy. Stopped-flow kinetic experiments were performed to measure the formation and dissociation rate constants of the monoadduct: k(1) = (6.01 ± 0.03) × 10(6) M(-1)s(-1) and k(-1) = 52.7 ± 0.4 s(-1), respectively. Possible mechanisms of complexation are discussed in view of the kinetic results. 相似文献
75.
Valiyaveetil FI Sekedat M MacKinnon R Muir TW 《Journal of the American Chemical Society》2006,128(35):11591-11599
The selectivity filter of K(+) channels comprises four contiguous ion binding sites, S1 through S4. Structural and functional data indicate that the filter contains on average two K(+) ions at any given time and that these ions reside primarily in two configurations, namely to sites S1 and S3 or to sites S2 and S4. Maximum ion flux through the channel is expected to occur when the energy difference between these two binding configurations is zero. In this study, we have used protein semisynthesis to selectively perturb site 1 within the filter of the KcsA channel through use of an amide-to-ester substitution. The modification alters K(+) conduction properties. The structure of the selectivity filter is largely unperturbed by the modification, despite the loss of an ordered water molecule normally located just behind the filter. Introduction of the ester moiety was found to alter the distribution of K(+), Rb(+,) and Cs(+) within the filter, with the most dramatic change found for Rb(+). The redistribution of ions is associated with the appearance of a partially hydrated ion just external to the filter, at a position where no ion is observed in the wild-type channel. The appearance of this new ion-binding site creates a change in the distance between a pair of K(+) ions some fraction of the time, apparently leading to a reduction in the ion conduction rate. Importantly, this finding suggests that the selectivity filter of a potassium channel is optimized both in terms of absolute ion occupancy and in terms of the separation in distance between the conducting ions. 相似文献
76.
Gerald Whittaker Remegio Confesor Jr. Stephen M. Griffith Rolf Färe Shawna Grosskopf Jeffrey J. Steiner George W. Mueller-Warrant Gary M. Banowetz 《European Journal of Operational Research》2009
The objective of this research was the development of a method that integrated an activity analysis model of profits from production with a biophysical model, and included the capacity for optimization over multiple objectives. We specified a hybrid genetic algorithm using activity analysis as a local search method, and NSGA-II for calculation of the multiple objective Pareto optimal set. We describe a parallel computing approach to computation of the genetic algorithm, and apply the algorithm to evaluation of an input tax to regulate pollution from agricultural production. 相似文献
77.
Döppner T Thomas CA Divol L Dewald EL Celliers PM Bradley DK Callahan DA Dixit SN Harte JA Glenn SM Haan SW Izumi N Kyrala GA LaCaille G Kline JK Kruer WL Ma T MacKinnon AJ McNaney JM Meezan NB Robey HF Salmonson JD Suter LJ Zimmerman GB Edwards MJ MacGowan BJ Kilkenny JD Lindl JD Van Wonterghem BM Atherton LJ Moses EI Glenzer SH Landen OL 《Physical review letters》2012,108(13):135006
We have imaged hard x-ray (>100 keV) bremsstrahlung emission from energetic electrons slowing in a plastic ablator shell during indirectly driven implosions at the National Ignition Facility. We measure 570 J in electrons with E>100 keV impinging on the fusion capsule under ignition drive conditions. This translates into an acceptable increase in the adiabat α, defined as the ratio of total deuterium-tritium fuel pressure to Fermi pressure, of 3.5%. The hard x-ray observables are consistent with detailed radiative-hydrodynamics simulations, including the sourcing and transport of these high energy electrons. 相似文献