2,6-Bis[4-(p-dihexylaminostyryl)styryl]anthracene derivatives with large two-photon cross sections

[Structure: see text] Anthracene derivatives with a variety of donor-acceptor substituents have been synthesized and shown to exhibit large two-photon cross sections over a wide range of wavelengths.     

Hydrothermal Synthesis and Optical Properties of ZnO Nanostructured Films Directly Grown from/on Zinc Substrates

Uniform ZnO nanorods arrays are grown directly from and on Zn foils in pure water under hydrothermal conditions at a relatively low temperature. The nanorods are 80–200 nm in diameter and ∼ 1 μm in length, which grow on the Zn foil along the [001] direction. By changing the pure water to a urea solution, a Zn compound ([Zn₅(OH)₆(CO₃)₂], a precursor of ZnO nanoflowers film, is created by self-assembly. The ZnO nanoflowers film can be easily obtained by heating the [Zn₅(OH)₆(CO₃)₂] compound in N₂ at 350∘C for 5–6 hours. Possible growth processes of the ZnO nanorods arrays and the [Zn₅(OH)₆(CO₃)₂] nanoflowers are discussed. Photoluminescence properties of the as-prepared ZnO nanostructures have been measured. The ZnO nanorods array synthesized using our method has minimal defects so that only band-gap emission is observed. However, the ZnO nanoflowers film, obtained by heating the [Zn₅(OH)₆(CO₃)₂] nanoflower precursor in N₂, is polycrystalline and displays strong defect-related emission.     

Synthesis,characterization and DNA-binding properties of mixed porphyrin–polypyridyl ruthenium(II) complexes

Two mixed porphyrin–polypyridyl Ru^II complexes [Ru(bpy)₂(MPyTPP)Cl]Cl (1) and [Ru(phen)₂(MPyTPP)Cl]Cl ( 2 ) (bpy=2,2-bipyridine; phen=1,10-phenanthroline; MPyTPP=5-monopyridyl-10,15,20–triphenylporphyrin) have been synthesized and characterized by elementary analysis, e.s.–m.s., cyclic voltammetry and u.v.–vis. spectroscopy. The DNA-binding properties of these complexes were investigated by electronic spectra, c.d. spectra and viscosity experiments. The results suggested that both complexes (1) and (2) bind to DNA in an outside binding mode. At the same time, theoretical calculations applying the ab initio and the density functional theory (DFT) methods were also performed, and the results showed that there is no good planarity on the main ligand MPyTPP of these complexes, and there are rather great distortion angles (dihedral angles ca. 72°) between the porphrin ring and each of the 10-, 15-, 20-phenyl groups. This may be the reason why the complexes bind to DNA in an outside mode, instead of an intercalative mode.     

Structure and stability of thiourea with water, DFT and MP2 calculations

The relative stabilities of thiourea in water are investigated computationally by considering thiourea–water complexes containing up to 1–6 water molecules (CS(NH₂)₂(H₂O)_n=1–6) using density functional theory and MP2 ab initio molecular orbital theory. The results show that the thiourea complex is stable and has an unusually high affinity for incoming water molecules. The clusters are progressively stabilized by the addition of water molecules, as indicated by the increasing of the binding energy. The binding energy of the cluster to each H₂O molecule is about 33 kJ mol⁻¹ for n=1–5.The C–S bond, N–C bond distance, Mulliken populations and binding energy keep approximately constant as the clusters increase in size with an increasing number of H₂O molecules. As the solvation progresses, the C–S distance increases monotonically while the Mulliken populations on the C–S bond reduces monotonically with the addition of each H₂O molecule, indicating that the C–S bond of the thiourea unit in the clusters is de-stabilized with an increasing number of H₂O molecules. Charge transfers for the clusters are mainly found at N, S atoms of the thiourea.     

Nitrophenol Derivatives Oxidized by Cerium(IV) Ammonium Nitrate (CAN) and Their Cytotoxicity

Oxidation of a series of phenols with cerium(IV) ammonium nitrate (CAN) in acetonitrile under mild conditions yields the mixture of corresponding nitrophenols. In the cases of methylphenols and hydroxy ‐carboxylic acids, the steric effect may reduce the nitration reaction. Compounds 3a and 4b showed selective activities to Hep 3B and Hep G2 cancer cell lines, respectively. Compound 2c showed selective activities to Hep G2 and MDA‐MB‐231 cancer cell lines. Furthermore, compound 10b showed selective activities to Hep G2, Hep 3B, MCF‐7 and MDA‐MB‐231 cancer cell lines.     

Analysis of Phenylpropanolamine by Micellar Electroknetic Chromatography with Laser‐induced Fluorescence Detection

A new analytical method for phenylpropanolamine based on micellar electrokinetic chromatographic separation and laser‐induced fluorescence detection has been developed. Naphthalene‐2,3‐dicarboxaldehyde was used for precolumn derivatization of the nonfluorescent drug. Optimal separation and detection were obtained with an electrophoretic buffer of 50 mM sodium borate (pH 9.5) containing 15 mM sodium dodecyl sulfate and a He‐Cd laser (Δ_ex: 442 nm, Δ_em: 500 nm). Linearity (r ≥ 0.99) of two orders of magnitude was generally obtained and the concentration limit of detection was in the ng/mL level. Coupled with a simple cleanup procedure, the method can be applied to the analysis of phenylpropanolamine in human plasma, with a limit of detection at 15 ng/mL. Recovery of phenylpropanolamine from plasma samples was about 90%.     

Synthesis and Characterization of Novel Organosoluble Methyl Substituted Poly(aryl Ether Ketone)s Containing Sulfone Linkage

Several new methyl substituted poly(aryl ether ketone)s containing sulfone linkage with inherent viscosities of 0.62–0.84 dL/g have been prepared from 4,4′‐bis(2‐methylphenoxy)diphenylsulfone and 4,4′‐bis(3‐methylphenoxy)diphenylsulfone with terephthaloyl chloride and isophthaloyl chloride by electrophilic Friedel‐Crafts acylation in the presence of DMF with anhydrous AlCl₃ as a catalyst in 1,2‐dichloroethane, respectively. These polymers having weight‐average molecular weight in the range of 71,000–49,000 are all amorphous and show high glass transition temperatures ranging from 167 °C to 191 °C, excellent thermal stability at temperatures over 400 °C in air or nitrogen, high char yields of 51–58% in nitrogen and good solubility in CHCl₃ and polar solvents such as DMF, DMSO and NMP at room temperature.     

An Unexpected and Green Synthetic Protocol for Ethyl 1‐Aroyl/Aroylmethyl‐5‐methyl‐3‐methylthiopyrazole‐4‐carboxylates: High Regioselectivity in Alkylation and Acylation Reactions between N‐1 and N‐2 of a Pyrazole Ring

Two series, totaling twelve, of new compounds, ethyl 1‐aroyl/(aroylmethyl)‐5‐methyl‐3‐methylthiopyrazole‐4‐carboxylates ( 5 / 6 ), have been synthesized via highly regioselectively acylation and alkylation reactions of ethyl 3‐methyl‐5‐methylthio‐1 H‐pyrazole‐4‐carboxylate ( 2a ) with aroyl chloride ( 3 ) and eco‐friendly reagents alpha‐tosyloxysubstituted acetophenones ( 4 ), respectively, and a green protocol has been developed. The acylation reactions were carried out under ultrasound irradiation, and the alkylation reactions were under microwave irradiation and ultrasound irradiation, respectively. Conventional reaction conditions, as well as the use of alpha‐bromosubstituted acetophenone ( 4 ′) have also been applied in the synthesis of some randomly selected compounds in both series and have generated identical compounds correspondingly. Unexpected structures of compounds were unambiguously determined by X‐ray crystallographic analysis.     

A novel three‐dimensional supra­molecular coordination polymer: poly­[[di­aqua­dicadmium(II)‐di‐μ2‐4,4′‐bipyridyl‐di‐μ2‐2‐sulfonatobenzoato] dihydrate]

The hydro­thermal reaction of Cd(CH₃COO)₂·2H₂O, 4,4′‐bipyridyl and 2‐sulfo­benzoic acid produced the title compound, {[Cd₂(C₇H₄O₅S)₂(C₁₀H₈N₂)₂(H₂O)₂]·2H₂O}_n, which forms a two‐dimensional coordination polymer, the sheets of which are linked via hydrogen bonds. Two different types of Cd atoms are present, one lying on a twofold rotation axis and the other on a centre of inversion. Similarly, there are two types of bipyridyl ligand present, one lying across a twofold rotation axis and the other across a centre of inversion.     

从一女性患者尿道分泌物中分离出气球菌样微生物

从在中山医科大学附属三院妇科门诊临床初诊为尿道炎的妇性患者的尿道分泌物中,分别两次,间隔４ｄ,重复分离出相同的ＡＬＯ菌株。